38 research outputs found
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Patient ethnicity and three psychiatric intensive care units compared: the Tompkins Acute Ward Study
Background: Psychiatric Care Units provide care to disturbed patients in a context of higher security and staffing levels. Although such units are numerous, few systematic comparisons have been made, and there are indications that ethnic minority groups may be over-represented.
Aim: To compare the rates of adverse incidents and patterns of usage of three Psychiatric Intensive Care Units.
Method: The study used a triangulation or multi-method design, bringing together data from official statistics, local audit and interviews conducted with staff.
Results: Intensive care patients were more likely to be young, male, and suffering a psychotic disorder, as compared to general acute ward patients. Caribbean patients were twice as likely, and Asian patients half as likely, to receive intensive care (age, gender and diagnosis controlled). There were large differences in service levels, staffing, team functioning and adverse incidents between the three units. Various aspects of physical security were important in preventing absconds.
Conclusions: More evaluative research is required in order to define effective service levels, and to explore the nature of the interaction between ethnicity and inpatient care provision during acute illness
Efficient photoionization for barium ion trapping using a dipole-allowed resonant two-photon transition
Two efficient and isotope-selective resonant two-photon ionization techniques
for loading barium ions into radio-frequency (RF)-traps are demonstrated. The
scheme of using a strong dipole-allowed transition at \lambda=553 nm as a first
step towards ionization is compared to the established technique of using a
weak intercombination line (\lambda=413 nm). An increase of two orders of
magnitude in the ionization efficiency is found favoring the transition at 553
nm. This technique can be implemented using commercial all-solid-state laser
systems and is expected to be advantageous compared to other narrowband
photoionization schemes of barium in cases where highest efficiency and
isotope-selectivity are required.Comment: 8 pages, 5 figure
Optimum electrode configurations for fast ion separation in microfabricated surface ion traps
For many quantum information implementations with trapped ions, effective
shuttling operations are important. Here we discuss the efficient separation
and recombination of ions in surface ion trap geometries. The maximum speed of
separation and recombination of trapped ions for adiabatic shuttling operations
depends on the secular frequencies the trapped ion experiences in the process.
Higher secular frequencies during the transportation processes can be achieved
by optimising trap geometries. We show how two different arrangements of
segmented static potential electrodes in surface ion traps can be optimised for
fast ion separation or recombination processes. We also solve the equations of
motion for the ion dynamics during the separation process and illustrate
important considerations that need to be taken into account to make the process
adiabatic
New loophole for the EPR paradox
We exhibit a classical model free from any paradox which exactly simulates
the spin EPR test. We conclude that Bell's inequality violation is a strictly
classical phenomenon, contrary to a general belief.Comment: Conversion from html to latex only. 16 pages, 1 figure late
Whole-genome sequencing reveals host factors underlying critical COVID-19
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Criminal Justice Act 1988
0.50SIGLEAvailable from British Library Document Supply Centre- DSC:3231.5(HO-C--16/1990) / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Forecasting wheat quality and the breadmaking premium from the North Atlantic oscillation
SIGLEAvailable from British Library Document Supply Centre- DSC:4303. 4478(no 308) / BLDSC - British Library Document Supply CentreGBUnited Kingdo