OGO-3 observations of ELF noise in the magnetosphere - Part 1 - Spatial extent and frequency of occurrence

OGO-3 spectrum analyzer measurements of magnetic noise in magnetospher

Asymptotic Sign-Solvability, Multiple Objective Linear Programming, and The Nonsubstitution Theorem

In this paper we investigate the asymptotic stability of dynamic, multiple-objective linear programs. In particular, we show that a generalization of the optimal partition stabilizes for a large class of data functions. This result is based on a new theorem about asymptotic sign-solvable systems. The stability properties of the generalized optimal partition are used to extend a dynamic version of the Nonsubstitution Theorem

Phase separation in a chaotic flow

The phase separation between two immiscible liquids advected by a bidimensional velocity field is investigated numerically by solving the corresponding Cahn-Hilliard equation. We study how the spinodal decomposition process depends on the presence -or absence- of Lagrangian chaos. A fully chaotic flow, in particular, limits the growth of domains and for unequal volume fractions of the liquids, a characteristic exponential distribution of droplet sizes is obtained. The limiting domain size results from a balance between chaotic mixing and spinodal decomposition, measured in terms of Lyapunov exponent and diffusivity constant, respectively.Comment: Minor changes - Version accepted for publication - Physical Review Letter

Coding of sexual assault by emergency physicians: A nationally representative study

INTRODUCTION: Sexual assault is a public health problem that affects many Americans and has multiple long-lasting effects on victims. Medical evaluation after sexual assault frequently occurs in the emergency department, and documentation of the visit plays a significant role in decisions regarding prosecution and outcomes of legal cases against perpetrators. The American College of Emergency Physicians recommends coding such visits as sexual assault rather than adding modifiers such as alleged. METHODS: This study reviews factors associated with coding of visits as sexual assault compared to suspected sexual assault using the 2016 Nationwide Emergency Department Sample. RESULTS: Younger age, female gender, a larger number of procedure codes, urban hospital location, and lack of concurrent alcohol use are associated with coding for confirmed sexual assault. CONCLUSION: Implications of this coding are discussed

Method for Isolation‬ ‪of Myxozoan proliferative stages‬ ‪from fish at high yield and purity:‬ ‪An essential prerequisite for in vitro,‬ ‪in vivo and genomics-based‬ ‪research developments.

Myxozoans are a diverse group of microscopic cnidarian parasites and some representatives are associated with important diseases in fish, in both marine and freshwater aquaculture systems. Research on myxozoans has been largely hampered by the inability to isolate myxozoan parasites from their host tissues. In this study, we developed and optimized a method to isolate the myxozoan proliferative stages of different size and cellularity from fish blood, using DEAE-cellulose ion exchange chromatography. We optimized several parameters and obtained 99–100% parasite purity, as well as high survival and infectivity. Using polyclonal pan-carp blood cell-specific antibodies, we further developed a rapid cytometric assay for quantification of the proliferative stages, not only in highly concentrated DEAE-C isolates but also in dilute conditions in full blood. Early developmental stages of myxozoans are key to parasite proliferation, establishment, and pathology in their hosts. The isolation of these stages not only opens new possibilities for in vivo and in vitro studies, but also for obtaining purified DNA and protein extracts for downstream analyses. Hence, we provide a long-desired tool that will advance the functional research into the mechanisms of host exploitation and immune stimulation/evasion in this group, which could contribute greatly to the development of therapeutic strategies against myxozoans

Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin

<p>Abstract</p> <p>Background</p> <p>Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV₁) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs). Inflammatory neuropeptides are suggested to be released from primary afferent nociceptors participating in inflammation. However, no direct evidence demonstrates that the release of inflammatory substances is due to the triggering of DRRs and how activation of TRPV₁receptors initiates neurogenic inflammation via triggering DRRs.</p> <p>Results</p> <p>Here we used pharmacological manipulations to analyze the roles of TRPV₁and neuropeptidergic receptors in the DRR-mediated neurogenic inflammation induced by intradermal injection of capsaicin. The degree of cutaneous inflammation in the hindpaw that followed capsaicin injection was assessed by measurements of local blood flow (vasodilation) and paw-thickness (edema) of the foot skin in anesthetized rats. Local injection of capsaicin, calcitonin gene-related peptide (CGRP) or substance P (SP) resulted in cutaneous vasodilation and edema. Removal of DRRs by either spinal dorsal rhizotomy or intrathecal administration of the GABA_Areceptor antagonist, bicuculline, reduced dramatically the capsaicin-induced vasodilation and edema. In contrast, CGRP- or SP-induced inflammation was not significantly affected after DRR removal. Dose-response analysis of the antagonistic effect of the TRPV₁receptor antagonist, capsazepine administered peripherally, shows that the capsaicin-evoked inflammation was inhibited in a dose-dependent manner, and nearly completely abolished by capsazepine at doses between 30–150 μg. In contrast, pretreatment of the periphery with different doses of CGRP_8–37(a CGRP receptor antagonist) or spantide I (a neurokinin 1 receptor antagonist) only reduced the inflammation. If both CGRP and NK₁receptors were blocked by co-administration of CGRP_8–37and spantide I, a stronger reduction in the capsaicin-initiated inflammation was produced.</p> <p>Conclusion</p> <p>Our data suggest that 1) the generation of DRRs is critical for driving the release of neuropeptides antidromically from primary afferent nociceptors; 2) activation of TRPV₁receptors in primary afferent nociceptors following intradermal capsaicin injection initiates this process; 3) the released CGRP and SP participate in neurogenic inflammation.</p

Non-Gaussian Distributions in Extended Dynamical Systems

We propose a novel mechanism for the origin of non-Gaussian tails in the probability distribution functions (PDFs) of local variables in nonlinear, diffusive, dynamical systems including passive scalars advected by chaotic velocity fields. Intermittent fluctuations on appropriate time scales in the amplitude of the (chaotic) noise can lead to exponential tails. We provide numerical evidence for such behavior in deterministic, discrete-time passive scalar models. Different possibilities for PDFs are also outlined.Comment: 12 pages and 6 figs obtainable from the authors, LaTex file, OSU-preprint-

(Anti)Proton and Pion Source Sizes and Phase Space Densities in Heavy Ion Collisions

NA44 has measured mid-rapidity deuteron spectra from AA collisions at sqrt{s}=18GeV/A at the CERN SPS. Combining these spectra with published proton, antiproton and antideuteron data allows us to calculate, within a coalescence framework, proton and antiproton source sizes and phase space densities. These results are compared to pion source sizes and densities, pA results and to lower energy (AGS) data. The antiproton source is larger than the proton source at sqrt{s}=18GeV/A. The phase space densities of pions and protons are not constant but grow with system size. Both pi+ and proton radii decrease with transverse mass and increase with sqrt{s}. Pions and protons do not freeze-out independently. The nature of their interaction changes as sqrt{s}, and the pion/proton ratio increases.Comment: 4 pages, Latex 2.09, 3 eps figures. Changes for January 2001. The proton source size is now calculated assuming a more realistic Hulthen, rather than Gaussian, wavefunction. A new figure shows the effect of this change which is important for small radii. A second new figure shows the results of RQMD calculations of the proton source size and phase density. Because of correlations between position and momentum coalesence does not show the full proton source size. The paper has been streamlined and readability improve