A Method for Predicting Dose Changes for HN Treatment Using Surface Imaging

Head and neck cancer is commonly treated with a six- to seven-week course of radiotherapy, during which a patient’s anatomy may change substantially, due to target reduction or weight loss. Anatomical changes lead to reduction in treatment quality due to decreased setup reproducibility and altered dose deposition compared to the original plan. Few clinics have developed a standard method for triggering resimulation and replan due to anatomic changes. This work investigates a new method for determining when to resimulate and replan HNC patients by utilizing their topographic anatomical changes to predict differences in planned versus delivered dose distributions. The first part of the work presents a method for deformable image registration of CT to CBCT which addresses the challenges of inaccurate Hounsfield units and truncated field of view present in CBCT. The registration method was validated on 10 HN patients using contour comparison, with average DSC of 0.82, 0.74, 0.72, and 0.69 for mandible, cord, and left and right parotid. The registration method was then used to generate dose maps and surface contours for 47 patients for the second part of this work, the development of a U-Net which takes the original dose distribution, the original surface, and the treatment day surface as input and predicts the treatment day dose distribution as output. The average RMSE and MAE between the true and predicted dose distributions for a test set of 6 patients was 4.25 and 2.15. This work proves feasibility of a dose prediction neural network using surface imaging

A 6-12 GHz Analogue Lag-Correlator for Radio Interferometry

Aims: We describe a 6-12 GHz analogue correlator that has been developed for use in radio interferometers. Methods: We use a lag-correlator technique to synthesis eight complex spectral channels. Two schemes were considered for sampling the cross-correlation function, using either real or complex correlations, and we developed prototypes for both of them. We opted for the ``add and square'' detection scheme using Schottky diodes over the more commonly used active multipliers because the stability of the device is less critical. Results: We encountered an unexpected problem, in that there were errors in the lag spacings of up to ten percent of the unit spacing. To overcome this, we developed a calibration method using astronomical sources which corrects the effects of the non-uniform sampling as well as gain error and dispersion in the correlator.Comment: 14 pages, 21 figures, accepted for publication in A&

A 6-12 GHz Analogue Lag-Correlator for Radio Interferometry

Aims: We describe a 6-12 GHz analogue correlator that has been developed for use in radio interferometers. Methods: We use a lag-correlator technique to synthesis eight complex spectral channels. Two schemes were considered for sampling the cross-correlation function, using either real or complex correlations, and we developed prototypes for both of them. We opted for the ``add and square'' detection scheme using Schottky diodes over the more commonly used active multipliers because the stability of the device is less critical. Results: We encountered an unexpected problem, in that there were errors in the lag spacings of up to ten percent of the unit spacing. To overcome this, we developed a calibration method using astronomical sources which corrects the effects of the non-uniform sampling as well as gain error and dispersion in the correlator.Comment: 14 pages, 21 figures, accepted for publication in A&

Ptychographic X-ray computed tomography of extended colloidal networks in food emulsions

As a main structural level in colloidal food materials, extended colloidal networks are important for texture and rheology. By obtaining the 3D microstructure of the network, macroscopic mechanical properties of the material can be inferred. However, this approach is hampered by the lack of suitable non-destructive 3D imaging techniques with submicron resolution. We present results of quantitative ptychographic X-ray computed tomography applied to a palm kernel oil based oil-in-water emulsion. The measurements were carried out at ambient pressure and temperature. The 3D structure of the extended colloidal network of fat globules was obtained with a resolution of around 300 nm. Through image analysis of the network structure, the fat globule size distribution was computed and compared to previous findings. In further support, the reconstructed electron density values were within 4% of reference values.Comment: 19 pages, 4 figures, to be published in Food Structur

The Role of Bacteria and Pattern Recognition Receptors in GvHD

Graft-versus-Host Disease (GvHD) is the most serious complication of allogeneic stem cell transplantation (SCT) and results from an activation of donor lymphocytes by recipient antigen-presenting cells (APCs). For a long time, it has been postulated that the intestinal microflora and endotoxin exert a crucial step in this APC activation, as there is early and severe gastrointestinal damage induced by pretransplant conditioning. With the detailed description of pathogen-associated molecular patterns and pathogen recognition receptors single nucleotide polymorphisms of TLRs and especially NOD2 have been identified as potential risk factors of GvHD and transplant related complications thus further supporting the crucial role of innate immunity in SCT, related complications. Gastrointestinal decontamination and neutralization of endotoxin have been used to interfere with this early axis of activation with some success but more specific approaches of modulation of innate immunity are needed for further improvement of clinical outcome