Single-shot implementation of dispersion-scan for the characterization of ultrashort laser pulses

[EN] We demonstrate a single-shot ultrafast diagnostic, based on the dispersion-scan (d-scan) technique. In this implementation, rather than translating wedges to vary the dispersion as in scanning d-scan, the pulse to be measured experiences a spatially varying amount of dispersion in a prism. The resulting beam is then imaged into a second-harmonic generation crystal and an imaging spectrometer is used to measure the two-dimensional trace, which is analyzed using the d-scan retrieval algorithm. We compare the single-shot implementation with the scanning d-scan for the measurement of sub-3.5-fs pulses from a hollow core fiber pulse compressor. We show that the retrieval algorithm used to extract amplitude and phase of the pulse provides comparable results, proving the validity of the new single-shot implementation in the near single-cycle regime. (C)2015 Optical Society of Americ

An Internal Perspective of Business Model Innovation in Manufacturing Companies

Business model innovation is increasingly being used as a concept in different academic fields, although it is still missing a ground theoretical conceptualization. This work aims at advancing the understanding of business model innovation from an internal perspective in manufacturing companies. It builds on a literature review regarding two main concepts – business model and business architecture – and proposes a set of key areas for internally-driven business model innovation. Six main areas have been identified: i) strategy & business goals; ii) organizational culture; iii) product and service management; iv) technology management; v) operations management; vi) performance management systems. Further research will analyze the innovation processes within each area, based on existing theoretical foundations and empirical studies. Moreover, new empirical studies will be performed to further investigate different potential pathways for business model innovation.This work builds on research initially undertaken on SustainValue project which received funding from the European Community´s Seventh Framework Programme (FP7/2007-2013) under grant agreement n°262931. Further review and analysis leading to these results was supported by the EPSRC Centre for Innovative Manufacturing in Industrial Sustainability (grant n° EP/I033351/1).This is the author accepted manuscript. The final version is available from IEEE via http://dx.doi.org/10.1109/CBI.2015.4

Economic and environmental impact assessment through system dynamics of technology-enhanced maintenance services

This work presents an economic and environmental impact assessment of maintenance services in order to evaluate how they contribute to sustainable value creation through field service delivery supported by advanced technologies. To this end, systems dynamics is used to assist the prediction of economic and environmental impacts of maintenance services supported by the use of an e-maintenance platform implementing prognosis and health management. A special concern is given to the energy use and related carbon footprint as environmental impacts

The IACOB project. VI. On the elusive detection of massive O-type stars close to the ZAMS

The apparent lack of massive O-type stars near the zero-age main sequence (at ages < 2 Myr) is a topic widely discussed. Different explanations for this elusive detection have been proposed, but no firm conclusions have been reached yet. We reassess this empirical result benefiting from the high-quality spectroscopic observations of >400 Galactic O-type stars gathered by the IACOB and OWN surveys. We used temperatures and gravities from a iacob-gbat/fastwind spectroscopic analysis to locate our sample in the Kiel and spectroscopic HR diagrams. We evaluated the completeness of our sample of stars, observational biases using information from the Galactic O star catalog (GOSC), systematics of our methodology, and compare with other recent studies using smaller samples of Galactic O-type stars. We base our discussion on the spectroscopic HR diagram to avoid the use of uncertain distances. We performed a detailed study of the young cluster Trumpler-14 as an example of how Gaia cluster distances can help to construct the associated classical HR diagram. The apparent lack of massive O-type stars near the ZAMS with masses between 30 and 70 Msol persist even when spectroscopic results from a large, non-biased sample of stars are used. We do not find correlation between the dearth of stars and observational biases, limitations of our methodology, or the use of spectroscopic HR diagram instead of the classical one. Investigating the efficiency of mass accretion during the formation process we conclude that an adjustment of the accretion rate towards lower values could reconcile the hotter boundary of detected O-type stars and the theoretical birthline. Last, we discuss that the presence of a small sample of O2-O3.5 stars found closer to the ZAMS might be explained taking into account non-standard star evolution (e.g. binary interaction, mergers, or homogeneous evolution).Comment: 20 pages, 15 figures, accepted for publication in Astronomy & Astrophysic

Continuous improvement planning through sustainability assessment of product-service systems

The paper presents a methodology for the integrated sustainability assessment of a product-service system lifecycle, with the purpose to support continuous improvement on the side both of the manufacturer and of the user. Its eight steps are an extension of ISO 14040 life cycle assessment and consider all three sustainability dimensions – economic, environmental and social – and a service perspective, using the service unit. A set of indicators for the three dimensions, aligned to the service unit concept, is proposed based on literature suggestions

Exploring the scope of industrial symbiosis: Implications for practitioners

Industrial Symbiosis can help improve the overall efficiency of the industrial system. The positive impact of implementing symbiotic exchanges between companies would benefit their host region through increased job creation and reduced environmental stress, whilst the entities engaged could benefit from a combination of additional revenue streams and reduced costs. However, in spite of the potential benefits of IS, there remains an implementation gap, with practitioners failing to fully exploit the possibilities of IS. The objective of this article is to provide a review of the current state of IS research in order to unlock current gaps of knowledge and practice, and identify research opportunities which will help close the implementation gap. The final aim is to explore and understand the areas practitioners willing to engage with IS need to consider in order to operationalize IS in their network.This work was supported by the European Union’s Horizon 2020 research and innovation program (grant n° 680570) and the EPSRC Centre for Innovative Manufacturing in Industrial Sustainability (grant n° EP/I033351/1).This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Springer

Rayleigh-wave attenuation by a semi-infinite two-dimensional elastic-band-gap crystal

In this paper, we report experiments on the scattering of surface-elastic waves by a periodic array of cylindrical holes. The experiments were performed in a marble quarry by drilling cylindrical holes in two different configurations: honeycomb and triangular lattices. The attenuation spectra of the surface waves show the existence of absolute band gaps for elastic waves in these semi-infinite two-dimensional crystals. Results are compared with theoretical calculations based on a scalar-wave approach. The scaling property of the underlying theory has led us to explore the possible application of the results obtained to the attenuation of surface waves in seismic movements.This work was partially supported by the Comisión Interministerial de Ciencia y Tecnología of Spain, Contract No. MAT97-0698-C04. We also thank the Consejo Superior de Investigaciones Científicas for the special funding to perform this experiment.Peer reviewe

Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression

The aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute/early) primary HIV infection (PHI) and up to one year post-infection (p.i). Samples from 14 healthy donors (HDs), 40 PHI patients, 17 Chronics, and 13 Elite controllers (ECs) were studied. The percentages of Th17 and Treg subsets were severely altered in Chronics, whereas all HIV-infected individuals (including ECs) showed Th17/Treg imbalance compared to HDs, in concordance with higher frequencies of activated CD8+ T-cells (HLA-DR+/CD38+). Better clinical status (higher CD4 counts, lower viral loads and activation) was associated with higher Th17 and lower Treg levels. We found positive correlations between Th17 at baseline and anti-HIV CD8+ T-cell functionality: viral inhibitory activity (VIA) and key polyfunctions (IFN-γ+/CD107A/B+) at both early and later times p.i, highlighting the prognostic value of Th17 cells to preserve an effective HIV T-cell immunity. Th17/Treg ratio and the IL-17 relative mean fluorescence intensity (rMFI of IL-17) were also positively correlated with VIA. Taken together, our results suggested a potential link between Th17 and Th17/Treg ratio with key HIV-specific CD8+ T-cell responses against the infection.Fil: Falivene, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Ghiglione, Yanina Alexandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Socías, María Eugenia. Fundación Huésped; ArgentinaFil: Holgado, María Pía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Ruiz, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Maeto, Cynthia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Figueroa, María Inés. Fundación Huésped; ArgentinaFil: Giavedoni, Luis D.. Texas Biomedical Research Institute; Estados UnidosFil: Cahn, Pedro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina. Fundación Huésped; ArgentinaFil: Salomon, Horacio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Sued, Omar Gustavo. Fundación Huésped; ArgentinaFil: Turk, Gabriela Julia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Gherardi, Maria Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentin

Harmless? A hierarchical analysis of poppers use correlates among young gay and bisexual men

© 2019 Australasian Professional Society on Alcohol and other Drugs Introduction and Aims: Poppers (alkyl nitrites) are recreational substances commonly used during sexual activity. The current legal status of poppers is complex and wide-ranging bans are increasingly under discussion. Research has identified disproportionate levels of poppers use in sexual minority men. While research on poppers use among sexual minority men exists, little is known about poppers use patterns and correlations with psychosocial and other factors among gay and bisexual young men. Design and Methods: A cross-sectional survey was conducted with 836 Australian gay and bisexual young men aged 18 to 35 years. Descriptive statistics and hierarchical segmentation analyses were conducted to identify poppers use patterns, and correlates of recent poppers use (past 3 months) with personal characteristics, use of other substances, as well as mental and psychosocial health including minority stress, LGBT-community connectedness and participation. Results: High levels of lifetime (38%, n = 315) and recent (24%, n = 204) poppers use were reported. However, few participants reported dependency symptoms, risky consumption or problems arising from using poppers. The final model included three variables (visiting sex-on-premises venues, licensed LGBT venues, and using other substances) and predicted 85% (n = 174) of recent poppers use. No correlations with other concepts or characteristics could be identified. Conclusion: This analysis further supports the hypothesis that poppers may be substances with a comparably low-risk profile. A regulation of poppers with a harm reduction approach may present a valuable public health intervention

Microfabrication processes for microfluidic devices on a single laser Workstation: direct writing lithography on SU-8, laser ablation on polymers and mask manufacturing

We demonstrate the capability of a laser micromachining workstation for cost-effective manufacturing of a variety of microfluidic devices, including SU-8 microchannels on silicon wafers and 3D complex structures made on polyimide Kapton® or poly carbonate (PC). The workstation combines a KrF excimer laser at 248 nm and a Nd3+:YVO4 DPSS with a frequency tripled at 355 nm with a lens magnification 10X, both lasers working at a pulsed regime with nanoseconds (ns) pulse duration. Workstation also includes a high-resolution motorized XYZ-tilt axis (~ 1 um / axis) and a Through The Lens (TTL) imaging system for a high accurate positioning over a 120 x 120 mm working area. We have surveyed different fabrication techniques: direct writing lithography,mask manufacturing for contact lithography and polymer laser ablation for complex 3D devices, achieving width channels down to 13μ m on 50μ m SU-8 thickness using direct writing lithography, and width channels of 40 μm for polyimide on SiO2 plate. Finally, we have tested the use of some devices for capillary chips measuring the flow speed for liquids with different viscosities. As a result, we have characterized the presence of liquid in the channel by interferometric microscopy