Oxygen-isotope effect on the superconducting gap in the cuprate superconductor Y_{1-x}Pr_xBa_2Cu_3O_{7-\delta}

The oxygen-isotope (^{16}O/^{18}O) effect (OIE) on the zero-temperature superconducting energy gap \Delta_0 was studied for a series of Y_{1-x}Pr_xBa_2Cu_3O_{7-\delta} samples (0.0\leq x\leq0.45). The OIE on \Delta_0 was found to scale with the one on the superconducting transition temperature. These experimental results are in quantitative agreement with predictions from a polaronic model for cuprate high-temperature superconductors and rule out approaches based on purely electronic mechanisms.Comment: 5 pages, 3 figure

External Shear in Quadruply Imaged Lens Systems

We use publicly available N-body simulations and semi-analytic models of galaxy formation to estimate the levels of external shear due to structure near the lens in gravitational lens systems. We also describe two selection effects, specific to four-image systems, that enhance the probability of observing systems to have higher external shear. Ignoring additional contributions from "cosmic shear" and assuming that lens galaxies are not significantly flattened, we find that the mean shear at the position of a quadruple lens galaxy is 0.11, the rms shear is roughly 0.15, and there is roughly a 45% likelihood of external shear greater than 0.1. This is much larger than previous estimates and in good agreement with typical measured external shear. The higher shear primarily stems from the tendency of early-type galaxies, which are the majority of lenses, to reside in overdense regions.Comment: 5 pages, 2 figures, ApJ in press, minor revision

A Signature of Cosmic Strings Wakes in the CMB Polarization

We calculate a signature of cosmic strings in the polarization of the cosmic microwave background (CMB). We find that ionization in the wakes behind moving strings gives rise to extra polarization in a set of rectangular patches in the sky whose length distribution is scale-invariant. The length of an individual patch is set by the co-moving Hubble radius at the time the string is perturbing the CMB. The polarization signal is largest for string wakes produced at the earliest post-recombination time, and for an alignment in which the photons cross the wake close to the time the wake is created. The maximal amplitude of the polarization relative to the temperature quadrupole is set by the overdensity of free electrons inside a wake which depends on the ionization fraction $f$ inside the wake. The signal can be as high as $0.06 {\rm \mu K}$ in degree scale polarization for a string at high redshift (near recombination) and a string tension $\mu$ given by $G \mu = 10^{-7}$.Comment: 8 pages, 3 figure

Validation of a finite-element solution for electrical impedance tomography in an anisotropic medium

Electrical impedance tomography is an imaging method, with which volumetric images of conductivity are produced by injecting electrical current and measuring boundary voltages. It has the potential to become a portable non-invasive medical imaging technique. Until now, implementations have neglected anisotropy even though human tissues such as bone, muscle and brain white matter are markedly anisotropic. We present a numerical solution using the finite-element method that has been modified for modelling anisotropic conductive media. It was validated in an anisotropic domain against an analytical solution in an isotropic medium after the isotropic domain was diffeomorphically transformed into an anisotropic one. Convergence of the finite element to the analytical solution was verified by showing that the finite-element error norm decreased linearly related to the finite-element size, as the mesh density increased, for the simplified case of Laplace's equation in a cubic domain with a Dirichlet boundary condition

A Sunyaev-Zel'dovich Effect Survey for High Redshift Clusters

Interferometric observations of the Sunyaev-Zel'dovich Effect (SZE) toward clusters of galaxies provide sensitive cosmological probes. We present results from 1 cm observations (at BIMA and OVRO) of a large, intermediate redshift cluster sample. In addition, we describe a proposed, higher sensitivity array which will enable us to survey large portions of the sky. Simulated observations indicate that we will be able to survey one square degree of sky per month to sufficient depth that we will detect all galaxy clusters more massive than 2x10^{14} h^{-1}_{50}M_\odot, regardless of their redshift. We describe the cluster yield and resulting cosmological constraints from such a survey.Comment: 7 pages, 6 figures, latex, contribution to VLT Opening Symposiu

Imaging the Sunyaev-Zel'dovich Effect

We report on results of interferometric imaging of the Sunyaev-Zel'dovich Effect (SZE) with the OVRO and BIMA mm-arrays. Using low-noise cm-wave receivers on the arrays, we have obtained high quality images for 27 distant galaxy clusters. We review the use of the SZE as a cosmological tool. Gas mass fractions derived from the SZE data are given for 18 of the clusters, as well as the implied constraint on the matter density of the universe, $\Omega_M$. We find $\Omega_M h_{100} \le 0.22 ^{+0.05}_{-0.03}$. A best guess for the matter density obtained by assuming a reasonable value for the Hubble constant and also by attempting to account for the baryons contained in the galaxies as well as those lost during the cluster formation process gives $\Omega_M \sim 0.25$. We also give preliminary results for the Hubble constant. Lastly, the power for investigating the high redshift universe with a non-targeted high sensitivity SZE survey is discussed and an interferometric survey is proposed.Comment: 14 pages, 7 figures, latex, contribution to Nobel Symposium "Particle Physics and the Universe" to appear in Physica Scripta and World Scientific, eds L. Bergstrom, P. Carlson and C. Fransso

Searching for "monogenic diabetes" in dogs using a candidate gene approach

BACKGROUND: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and similarities between canine and human diabetes phenotypes suggest that the same genes might be associated with disease susceptibility in both species. Between 1-5% of human diabetes cases result from mutations in a single gene, including maturity onset diabetes of the adult (MODY) and neonatal diabetes mellitus (NDM). It is not clear whether monogenic forms of diabetes exist within some dog breeds. Identification of forms of canine monogenic diabetes could help to resolve the heterogeneity of the condition and lead to development of breed-specific genetic tests for diabetes susceptibility. RESULTS: Seventeen dog breeds were screened for single nucleotide polymorphisms (SNPs) in eighteen genes that have been associated with human MODY/NDM. Six SNP associations were found from five genes, with one gene (ZFP57) being associated in two different breeds. CONCLUSIONS: Some of the genes that have been associated with susceptibility to MODY and NDM in humans appear to also be associated with canine diabetes, although the limited number of associations identified in this study indicates canine diabetes is a heterogeneous condition and is most likely to be a polygenic trait in most dog breeds. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2052-6687-1-8) contains supplementary material, which is available to authorized users