Concert recording 2017-12-06

[Track 1]. Allegro barbaro, BB63 / Béla Bartok -- [Track 2]. Etude in A♭ major, op. 25, no. 1 / Frédéric Chopin -- [Track 3]. Solo de concours, op. 10 / Henri Rabaud -- [Track 4]. Concerto no. 2 in F minor, op. 5. III. Rondo: Allegretto / Bernard Crusell -- [Track 5]. Premiere rhapsodie / Claude Debussy -- [Track 6]. Solo de concours, op. 10 / Henri Rabaud -- [Track 6]. Sonata for clarinet and piano. IV. Mässig bewegt / Paul Hindemith -- [Track 7]. Sonata for trumpet in B♭ major / Paul Hindemit

Concert recording 2017-11-30b

[Track 1]. Sonata for clarinet and piano. I. Mässig bewegt / Paul Hindemith -- [Track 2]. Concertino in E♭ major, op. 26 / Carl Maria von Weber -- [Track 3]. Five bagatelles for clarinet and piano, op. 23. I. Prelude / Gerald Finzi -- [Track 4]. Solo de concours, op. 10 / Henri Rabaud -- [Track 5]. Concerto no. 2 in E♭ major, op. 74. III. Alla polacca / Weber -- [Track 6]. Six studies in English folk song. II. Andante sostenuto (\u27Spurn point\u27) [Track 7]. III. Larghetto ( Van Dieman\u27s land\u27) in D modal minor [Track 8]. IV. Lento (\u27She borrowed some of her mother\u27s gold\u27) in D major / Ralph Vaughan Williams -- [Track 9]. Concerto no. 2 in F minor, op. 5. III. Rondo: allegretto / Bernard Crusell -- [Track 10]. Premiere rhapsodie / Claude Debussy -- [Track 11]. Fantasy for clarinet and piano / Carl Nielsen

Concert recording 2018-11-29

[Track 1]. French suite. I. Prelude [Track 2]. III. Gavotte / Yvonne Desportes -- [Track 3]. Flower duet from Lakmé / Léo Delibes -- [Track 4]. Hilltribe dance / Yos Vannesorn -- [Track 5]. Toccata and fugue in D minor, BMV 565 / J.S. Bach arranged by A. Brackett -- [Track 6]. Molly on the shore / Percy Grainger arranged by S. Knight -- [Track 7]. Chorale and danza / Vaclac Nelhybel -- [Track 8]. Klezmer suite / Alexis Ciesla

Concert recording 2019-04-17

[Track 1]. Concerto for clarinet and string orchestra / Aaron Copland -- [Track 2]. Dance preludes. I. Allegro molto [Track 3]. II. Andantino [Track 4]. III. Allegro giocoso / Witold Lutoslawski -- [Track 5]. Sonata for clarinet and piano in B♭major. I. Mäβig bewegt [Track 6]. IV. Kleines rondo. Gemächlich / Paul Hindemith -- [Track 7]. Five bagatelles, op. 23. I. Prelude / Gerald Finzi -- [Track 8]. Five bagatelles, op. 23. V. Fughetta / Gerald Finzi -- [Track 9]. Sonata for clarinet in B♭ and piano. I. Allegro tristamente / Francis Poulenc -- [Track 10]. Sonata for clarinet in B♭ and piano. III. Allegro con fuoco / Francis Poulenc -- [Track 11]. Introduction, theme and variations: Theme, var. 1, 2, 3, minor and major / Gioachino Rossini -- [Track 12]. Time pieces. I. Allegro risoluto [Track 13]. II. Andante espressivo / Robert Muczynski -- [Track 14].Sonata for clarinet, op. 120, no. 1. I. Allegro appassionato / Johannes Brahms -- [Track 15]. Wind in the reeds. I. March [Track 16]. II. Humoreske [Track 17]. III. A childhood memory [Track 18]. IV. Ballet russe / Gordon Jacob

Is detection of enteropathogens and human or animal faecal markers in the environment associated with subsequent child enteric infections and growth: an individual participant data meta-analysis.

BACKGROUND: Quantifying contributions of environmental faecal contamination to child diarrhoea and growth faltering can illuminate causal mechanisms behind modest health benefits in recent water, sanitation, and hygiene (WASH) trials. We aimed to assess associations between environmental detection of enteropathogens and human or animal microbial source tracking markers (MSTM) and subsequent child health outcomes. METHODS: In this individual participant data meta-analysis we searched we searched PubMed, Embase, CAB Direct Global Health, Agricultural and Environmental Science Database, Web of Science, and Scopus for WASH intervention studies with a prospective design and concurrent control that measured enteropathogens or MSTM in environmental samples, or both, and subsequently measured enteric infections, diarrhoea, or height-for-age Z-scores (HAZ) in children younger than 5 years. We excluded studies that only measured faecal indicator bacteria. The initial search was done on Jan 19, 2021, and updated on March 22, 2023. One reviewer (AM) screened abstracts, and two independent reviewers (AM and RT) examined the full texts of short-listed articles. All included studies include at least one author that also contributed as an author to the present Article. Our primary outcomes were the 7-day prevalence of caregiver-reported diarrhoea and HAZ in children. For specific enteropathogens in the environment, primary outcomes also included subsequent child infection with the same pathogen ascertained by stool testing. We estimated associations using covariate-adjusted regressions and pooled estimates across studies. FINDINGS: Data from nine published reports from five interventions studies, which included 8603 children (4302 girls and 4301 boys), were included in the meta-analysis. Environmental pathogen detection was associated with increased infection prevalence with the same pathogen and lower HAZ (ΔHAZ -0·09 [95% CI -0·17 to -0·01]) but not diarrhoea (prevalence ratio 1·22 [95% CI 0·95 to 1·58]), except during wet seasons. Detection of MSTM was not associated with diarrhoea (no pooled estimate) or HAZ (ΔHAZ -0·01 [-0·13 to 0·11] for human markers and ΔHAZ -0·02 [-0·24 to 0·21] for animal markers). Soil, children's hands, and stored drinking water were major transmission pathways. INTERPRETATION: Our findings support a causal chain from pathogens in the environment to infection to growth faltering, indicating that the lack of WASH intervention effects on child growth might stem from insufficient reductions in environmental pathogen prevalence. Studies measuring enteropathogens in the environment should subsequently measure the same pathogens in stool to further examine theories of change between WASH, faecal contamination, and health. Given that environmental pathogen detection was predictive of infection, programmes targeting specific pathogens (eg, vaccinations and elimination efforts) can environmentally monitor the pathogens of interest for population-level surveillance instead of collecting individual biospecimens. FUNDING: The Bill & Melinda Gates Foundation and the UK Foreign and Commonwealth Development Office

Concert recording 2019-11-16c

[Track 1]. Overture in B-flat Major, GVW 484. II. Air / Christoph Graupner arr. Holcomb -- [Track 2]. Clarinet sonata in B-flat Major. III. Rondo / John Baptist Vanhal -- [Track 3]. Divertimento no. 3 in B-flat Major, KV Anh. 229 (439b). I. Allegro [Track 4]. II. Menuetto [Track 5]. III. Adagio [Track 6]. IV. Menuetto [Track 7]. V. Rondo: Allegro assai / W.A. Mozart arr. Trio di Clarone -- [Track 8]. Fantasy for clarinet and piano / Carl Nielsen -- [Track 9]. Sonata for clarinet and piano. I. Allegro tristamente [Track 10]. II. Romanza [Track 11]. III. Allegro con fuoco / Francis Poulenc -- [Track 12]. Four fantasies for clarinet and marimba. I. Sunrise over endless green expanse [Track 13]. III. A brief encounter with strange people / Marco Schirripa

Table_1_Aging and feature binding in visual working memory.xlsx

Older adults have reduced performance in visual working memory tasks in comparison to young adults, but the precipitators of the age-related impairment are not fully understood. The most common interpretation of this difference is that older adults are incapable of maintaining the same amount of object representations as young adults over short intervals (in line with the fixed-slot model of working memory). However, it has remained largely unexplored whether the age-related decline is only due to the number of representations that older individuals can retain in visual working memory, or whether the content of the representation(s) may have an effect as well (in line with the flexible-resource model of working memory). Feature binding studies represent an interesting research line to examine the content of older adults' representations. In this mini-review, we present the main results across feature binding studies in aging, as well as highlight the importance of manipulating both the representation content and number to have a stress test of the various models of working memory and their contribution to aging. Overall, feature binding studies, together with the simultaneous manipulation of set size, will allow us to better understand the nature of the age-related decline of visual working memory.</p

Effects of water, sanitation, and hygiene interventions on detection of enteropathogens and host-specific faecal markers in the environment: a systematic review and individual participant data meta-analysis.

BackgroundWater, sanitation, and hygiene (WASH) improvements are promoted to reduce diarrhoea in low-income countries. However, trials from the past 5 years have found mixed effects of household-level and community-level WASH interventions on child health. Measuring pathogens and host-specific faecal markers in the environment can help investigate causal pathways between WASH and health by quantifying whether and by how much interventions reduce environmental exposure to enteric pathogens and faecal contamination from human and different animal sources. We aimed to assess the effects of WASH interventions on enteropathogens and microbial source tracking (MST) markers in environmental samples.MethodsWe did a systematic review and individual participant data meta-analysis, which included searches from Jan 1, 2000, to Jan 5, 2023, from PubMed, Embase, CAB Direct Global Health, Agricultural and Environmental Science Database, Web of Science, and Scopus, of prospective studies with water, sanitation, or hygiene interventions and concurrent control group that measured pathogens or MST markers in environmental samples and measured child anthropometry, diarrhoea, or pathogen-specific infections. We used covariate-adjusted regression models with robust standard errors to estimate study-specific intervention effects and pooled effect estimates across studies using random-effects models.FindingsFew trials have measured the effect of sanitation interventions on pathogens and MST markers in the environment and they mostly focused on onsite sanitation. We extracted individual participant data on nine environmental assessments from five eligible trials. Environmental sampling included drinking water, hand rinses, soil, and flies. Interventions were consistently associated with reduced pathogen detection in the environment but effect estimates in most individual studies could not be distinguished from chance. Pooled across studies, we found a small reduction in the prevalence of any pathogen in any sample type (pooled prevalence ratio [PR] 0·94 [95% CI 0·90-0·99]). Interventions had no effect on the prevalence of MST markers from humans (pooled PR 1·00 [95% CI 0·88-1·13]) or animals (pooled PR 1·00 [95% CI 0·97-1·03]).InterpretationThe small effect of these sanitation interventions on pathogen detection and absence of effects on human or animal faecal markers are consistent with the small or null health effects previously reported in these trials. Our findings suggest that the basic sanitation interventions implemented in these studies did not contain human waste and did not adequately reduce exposure to enteropathogens in the environment.FundingBill and Melinda Gates Foundation and the UK Foreign and Commonwealth Development Office

Effects of water, sanitation, and hygiene interventions on detection of enteropathogens and host-specific faecal markers in the environment: a systematic review and individual participant data meta-analysis.

BACKGROUND: Water, sanitation, and hygiene (WASH) improvements are promoted to reduce diarrhoea in low-income countries. However, trials from the past 5 years have found mixed effects of household-level and community-level WASH interventions on child health. Measuring pathogens and host-specific faecal markers in the environment can help investigate causal pathways between WASH and health by quantifying whether and by how much interventions reduce environmental exposure to enteric pathogens and faecal contamination from human and different animal sources. We aimed to assess the effects of WASH interventions on enteropathogens and microbial source tracking (MST) markers in environmental samples. METHODS: We did a systematic review and individual participant data meta-analysis, which included searches from Jan 1, 2000, to Jan 5, 2023, from PubMed, Embase, CAB Direct Global Health, Agricultural and Environmental Science Database, Web of Science, and Scopus, of prospective studies with water, sanitation, or hygiene interventions and concurrent control group that measured pathogens or MST markers in environmental samples and measured child anthropometry, diarrhoea, or pathogen-specific infections. We used covariate-adjusted regression models with robust standard errors to estimate study-specific intervention effects and pooled effect estimates across studies using random-effects models. FINDINGS: Few trials have measured the effect of sanitation interventions on pathogens and MST markers in the environment and they mostly focused on onsite sanitation. We extracted individual participant data on nine environmental assessments from five eligible trials. Environmental sampling included drinking water, hand rinses, soil, and flies. Interventions were consistently associated with reduced pathogen detection in the environment but effect estimates in most individual studies could not be distinguished from chance. Pooled across studies, we found a small reduction in the prevalence of any pathogen in any sample type (pooled prevalence ratio [PR] 0·94 [95% CI 0·90-0·99]). Interventions had no effect on the prevalence of MST markers from humans (pooled PR 1·00 [95% CI 0·88-1·13]) or animals (pooled PR 1·00 [95% CI 0·97-1·03]). INTERPRETATION: The small effect of these sanitation interventions on pathogen detection and absence of effects on human or animal faecal markers are consistent with the small or null health effects previously reported in these trials. Our findings suggest that the basic sanitation interventions implemented in these studies did not contain human waste and did not adequately reduce exposure to enteropathogens in the environment. FUNDING: Bill and Melinda Gates Foundation and the UK Foreign and Commonwealth Development Office