2,713 research outputs found
Design evolution of the orbiter reaction control subsystem
The challenges of space shuttle orbiter reaction control subsystem development began with selection of the propellant for the subsystem. Various concepts were evaluated before the current Earth storable, bipropellant combination was selected. Once that task was accomplished, additional challenges of designing the system to satisfy the wide range of requirements dictated by operating environments, reusability, and long life were met. Verification of system adequacy was achieved by means of a combination of analysis and test. The studies, the design efforts, and the test and analysis techniques employed in meeting the challenges are described
No-go theorem for bimetric gravity with positive and negative mass
We argue that the most conservative geometric extension of Einstein gravity
describing both positive and negative mass sources and observers is bimetric
gravity and contains two copies of standard model matter which interact only
gravitationally. Matter fields related to one of the metrics then appear dark
from the point of view of an observer defined by the other metric, and so may
provide a potential explanation for the dark universe. In this framework we
consider the most general form of linearized field equations compatible with
physically and mathematically well-motivated assumptions. Using gauge-invariant
linear perturbation theory, we prove a no-go theorem ruling out all bimetric
gravity theories that, in the Newtonian limit, lead to precisely opposite
forces on positive and negative test masses.Comment: 19 pages, no figures, journal versio
Propagation of gravitational waves in multimetric gravity
We discuss the propagation of gravitational waves in a recently discussed
class of theories containing N >= 2 metric tensors and a corresponding number
of standard model copies. Using the formalism of gauge-invariant linear
perturbation theory we show that all gravitational waves propagate at the speed
of light. We then employ the Newman-Penrose formalism to show that two to six
polarizations of gravitational waves may exist, depending on the parameters
entering the equations of motion. This corresponds to E(2) representations N_2,
N_3, III_5 and II_6. We finally apply our general discussion to a recently
presented concrete multimetric gravity model and show that it is of class N_2,
i.e., it allows only two tensor polarizations, as it is the case for general
relativity. Our results provide the theoretical background for tests of
multimetric gravity theories using the upcoming gravitational wave experiments.Comment: 21 pages, no figures, journal versio
Multimetric extension of the PPN formalism: experimental consistency of repulsive gravity
Recently we discussed a multimetric gravity theory containing several copies
of standard model matter each of which couples to its own metric tensor. This
construction contained dark matter sectors interacting repulsively with the
visible matter sector, and was shown to lead to cosmological late-time
acceleration. In order to test the theory with high-precision experiments
within the solar system we here construct a simple extension of the
parametrized post-Newtonian (PPN) formalism for multimetric gravitational
backgrounds. We show that a simplified version of this extended formalism
allows the computation of a subset of the PPN parameters from the linearized
field equations. Applying the simplified formalism we find that the PPN
parameters of our theory do not agree with the observed values, but we are able
to improve the theory so that it becomes consistent with experiments of
post-Newtonian gravity and still features its promising cosmological
properties.Comment: 19 pages, no figures, journal versio
An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present study asked whether IL-33/ST2 signaling is relevant to overt pain-like behaviors in mice. Acetic acid and phenyl-p-benzoquinone induced significant writhing responses in wild-type (WT) mice; this overt nociceptive behavior was reduced in ST2-deficient mice. In an antigen-challenge model, ST2-deficient immunized mice had reduced induced flinch and licking overt pain-like behaviors. In the formalin test, ST2-deficient mice also presented reduced flinch and licking responses, compared with WT mice. Naive WT and ST2-deficient mice presented similar responses in the rota-rod, hot plate, and electronic von Frey tests, indicating no impairment of motor function or alteration in basal nociceptive responses. The results demonstrate that IL-33/ST2 signaling is important in the development of overt pain-like behaviors
Blood testosterone levels in sickness and in health: Male chimpanzee testosterone levels decrease in face of an immune challenge
As an integral part of the immune response, testosterone secretion is inhibited when an individual is confronted with an immune challenge. Testosterone-mediated physiological, morphological, and behavioral traits are compromised at times of impaired health. Nevertheless, males of some species seem to maintain high levels of testosterone when confronted with an immune challenge, upholding competitive strength but compromising their immune response. It has been argued that this phenomenon will occur only in species living in social systems with high degrees of male-male competition over mating opportunities. Male chimpanzees contest over access to fertile females and dominants sire the majority of offspring. This male mating pattern makes chimpanzees a candidate species where we could expect males to maintain high testosterone levels, compromising their immune response, to ensure immediate reproductive success. We measured blood testosterone levels in male and female chimpanzees, who expressed clinical symptoms (symptomatic) or showed no evidence of clinical disease on assessment (asymptomatic). For females, we expected to find lower testosterone levels in symptomatic individuals than in asymptomatic subjects. In males, we would predict lower testosterone levels in symptomatic individuals than in asymptomatic males, if the immune response leads to a decrease in testosterone secretion. Alternatively, males could have equal levels of testosterone when symptomatic and asymptomatic, upholding competitive strength. Our results show that male chimpanzees exhibit lower levels of testosterone when confronted with an immune challenge than when being asymptomatic. This suggests that male testosterone secretion is suppressed as part of the immune response, which potentially increases survival and lifetime reproductive success. It will, however, negatively impact momentary competitive ability. Also, males may employ different mating strategies, some of which are less testosterone-driven (e.g., affiliative strategies). Consequently, in some individuals, the costs of maintaining high testosterone levels may not outweigh the potential gain in reproductive success
Plasma testosterone and androstenedione levels follow the same sex-specific patterns in the two Pan species
In most animals, males are considered more aggressive, in terms of frequency and intensity of aggressive behaviors, than their female peers. However, in several species this widespread male-biased aggression pattern is either extenuated, absent, or even sex-reversed. Studies investigating potential neuro-physiological mechanisms driving the selection for female aggression in these species have revealed an important, but not exclusive role of androgens in the expression of the observed sex-specific behavioral patterns. Two very closely related mammalian species that markedly differ in the expression and degree of sex-specific aggression are the two Pan species, where the chimpanzee societies are male-dominated while in bonobos sex-biased aggression patterns are alleviated. Using liquid chromatography–mass spectrometry (LC-MS) methods, we measured levels of plasma testosterone and androstenedione levels in male and female zoo-housed bonobos (N = 21; 12 females, 9 males) and chimpanzees (N = 41; 27 females, 14 males). Our results show comparable absolute and relative intersexual patterns of blood androgen levels in both species of Pan. Plasma testosterone levels were higher in males (bonobos: females: average 0.53 ± 0.30 ng/mL; males 6.70 ± 2.93 ng/mL; chimpanzees: females: average 0.40 ± 0.23 ng/mL; males 5.84 ± 3.63 ng/mL) and plasma androstenedione levels were higher in females of either species (bonobos: females: average 1.83 ± 0.87 ng/mL; males 1.13 ± 0.44 ng/mL; chimpanzees: females: average 1.84 ± 0.92 ng/mL; males 1.22 ± 0.55 ng/mL). The latter result speaks against a role of androstenedione in the mediation of heightened female aggression, as had been suggested based on studies in other mammal species where females are dominant and show high levels of female aggressivenes
MYND: Unsupervised Evaluation of Novel BCI Control Strategies on Consumer Hardware
Neurophysiological studies are typically conducted in laboratories with
limited ecological validity, scalability, and generalizability of findings.
This is a significant challenge for the development of brain-computer
interfaces (BCIs), which ultimately need to function in unsupervised settings
on consumer-grade hardware. We introduce MYND: A framework that couples
consumer-grade recording hardware with an easy-to-use application for the
unsupervised evaluation of BCI control strategies. Subjects are guided through
experiment selection, hardware fitting, recording, and data upload in order to
self-administer multi-day studies that include neurophysiological recordings
and questionnaires. As a use case, we evaluate two BCI control strategies
("Positive memories" and "Music imagery") in a realistic scenario by combining
MYND with a four-channel electroencephalogram (EEG). Thirty subjects recorded
70.4 hours of EEG data with the system at home. The median headset fitting time
was 25.9 seconds, and a median signal quality of 90.2% was retained during
recordings.Neural activity in both control strategies could be decoded with an
average offline accuracy of 68.5% and 64.0% across all days. The repeated
unsupervised execution of the same strategy affected performance, which could
be tackled by implementing feedback to let subjects switch between strategies
or devise new strategies with the platform.Comment: 9 pages, 5 figures. Submitted to PNAS. Minor revisio
Comparing teacher roles in Denmark and England
This article reports the findings of a comparative study of teaching in Denmark and England; its broader aim is to help develop an approach for comparing pedagogy. Lesson observations and interviews identified the range of goals towards which teachers in each country worked and the actions these prompted. These were clustered using the lens of Bernstein’s pedagogic discourse (1990; 1996) to construct teacher roles which provided a view of pedagogy. Through this approach we have begun to identify variations in pedagogy across two countries. All teachers in this study adopted a variety of roles; of significance was the ease with which competent English teachers moved between roles. The English teachers observed adopted roles consistent with a wider techno-rationalist discourse. There was a greater subject emphasis by Danish teachers whose work was set predominantly within a democratic humanist discourse, whilst the English teachers placed a greater emphasis on applied skills
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