Time Delay Effects on Coupled Limit Cycle Oscillators at Hopf Bifurcation

We present a detailed study of the effect of time delay on the collective dynamics of coupled limit cycle oscillators at Hopf bifurcation. For a simple model consisting of just two oscillators with a time delayed coupling, the bifurcation diagram obtained by numerical and analytical solutions shows significant changes in the stability boundaries of the amplitude death, phase locked and incoherent regions. A novel result is the occurrence of amplitude death even in the absence of a frequency mismatch between the two oscillators. Similar results are obtained for an array of N oscillators with a delayed mean field coupling and the regions of such amplitude death in the parameter space of the coupling strength and time delay are quantified. Some general analytic results for the N tending to infinity (thermodynamic) limit are also obtained and the implications of the time delay effects for physical applications are discussed.Comment: 20 aps formatted revtex pages (including 13 PS figures); Minor changes over the previous version; To be published in Physica

Разработка программы продвижения товара на рынок

Рассмотрены теоретические основы продвижения продукции, понятия, значение, методы. Представлен анализ продвижения товаров на рынке Томской области на примере сети магазинов "Фабрика дверей". Дана оценка затрат на реализацию предлагаемых мероприятий. Предложены программы продвижения товаров и услуг компании.The theoretical bases of product promotion, concepts, meaning, methods are considered. The analysis of goods promotion on the market of Tomsk region is presented on the example of the chain of shops "Factory of doors". The cost of the proposed activities is estimated. Programs to promote the company's products and services are offered

Финансовое управление проектами на предприятии

Объектом исследования выступил проект "Чистая вода" Томской области. Цель работы – создание модели финансового управления проектами В процессе работы проводилось разработка модели финансового управления проектом ориентированной на основные процессы, протекающие в рамках проекта. В результате работы была разработана модель финансового управления проектом, позволяющая выделить процессы проекта и на их основе проводить анализ затрат.The object of the research was the project “Clean Water” of the Tomsk Region. The purpose of the work is to create a model of financial project management In the course of the work, a model of financial management of the project focused on the main processes taking place within the project was developed. As a result of the work, a model of financial management of the project was developed, allowing to single out the processes of the project and, on their basis, carry out a cost analysis

In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis

Currently, our knowledge of how pathogenic fungi grow in mammalian host environments is limited. Using a chemotherapeutic murine model of invasive pulmonary aspergillosis (IPA) and 1H-NMR metabolomics, we detected ethanol in the lungs of mice infected with Aspergillus fumigatus. This result suggests that A. fumigatus is exposed to oxygen depleted microenvironments during infection. To test this hypothesis, we utilized a chemical hypoxia detection agent, pimonidazole hydrochloride, in three immunologically distinct murine models of IPA (chemotherapeutic, X-CGD, and corticosteroid). In all three IPA murine models, hypoxia was observed during the course of infection. We next tested the hypothesis that production of ethanol in vivo by the fungus is involved in hypoxia adaptation and fungal pathogenesis. Ethanol deficient A. fumigatus strains showed no growth defects in hypoxia and were able to cause wild type levels of mortality in all 3 murine models. However, lung immunohistopathology and flow cytometry analyses revealed an increase in the inflammatory response in mice infected with an alcohol dehydrogenase null mutant strain that corresponded with a reduction in fungal burden. Consequently, in this study we present the first in vivo observations that hypoxic microenvironments occur during a pulmonary invasive fungal infection and observe that a fungal alcohol dehydrogenase influences fungal pathogenesis in the lung. Thus, environmental conditions encountered by invading pathogenic fungi may result in substantial fungal metabolism changes that influence subsequent host immune responses