Health behavioural theories and their application to women's participation in mammography screening

The most effective method of detecting breast cancer amongst asymptomatic women is by mammography screening. Although, most countries have this preventive measure in place for women within their society; most of these programmes still struggle with women’s attendance. This article discusses four health behavioural theories and models, in relation to mammography screening, including the health belief model, theory of planned behaviour, trans-theoretical model, and the theory of care seeking behaviour that may explain the factors affecting women's participation in mammography screening. In summary, analysis of these theories indicates that the theory of care seeking behaviour has value for exploring the factors affecting women's participation in mammography screening. This is because of its sensitivity to socioeconomic differences that exists amongst women in the society, and that it has a broader construct (such as habit and external factors) compared to the other health behavioural theories

Mammography screening in Nigeria – a critical comparison to other countries

Breast cancer is a leading cause of death among women, and according to the World Health Organisation (WHO) there will be a significant increase in the incidence of breast cancer in developing countries such as Nigeria by 2030. However, mammography screening can significantly reduce the mortality and morbidity of women as a result of breast cancer. Therefore, the aim of this review is to evaluate the mammography screening program in Nigeria, compare it with four developed countries and then draw inferences. The Nigerian screening program was evaluated using the following factors: - mode of invitation, frequency of screening, age of the participants, image projections, imaging staff, quality assurance program, and availability. Similarities exist between Nigeria and four developed countries (the United States of America, United Kingdom, Australia and Canada), for instance trained Radiographers do the imaging and the image projections obtained are the same. However, important differences exist, these include mode of invitation, financial model, quality assurance program and availability. On comparison with the four developed countries, various issues have been identified within the Nigerian breast screening programmes. No one simple solution can be offered to address these as the challenges are multi-factorial

Using the making Visible the ImpaCT Of Research (VICTOR) questionnaire to evaluate the benefits of a fellowship programme for nurses, midwives and allied health professionals

Background: There is increasing emphasis in the UK on developing a nurse, midwife and allied health professional (NMAHP) workforce that conducts research. Training for clinical academic careers is provided by the National Institute for Health and Care Research (NIHR). However, the low number of successful applicants suggested there were barriers to achieving this. The Centre for Nursing and Midwifery Led Research (CNMR) launched a fellowship programme in 2016 to backfill two days a week of NMAHPs’ time for up to a year, to give them time to make competitive applications to the NIHR. Aim: To report a study evaluating the CNMR fellowship programme. Discussion: The making Visible the ImpaCT Of Research (VICTOR) tool (Cooke et al 2019) was developed to describe the organisational impact of research. The 2016-17 CNMR fellows completed VICTOR and their responses were analysed using a framework approach. The analysis found the main benefits of participating in the programme were protected time for research, opportunities to develop collaborations, increasing intra- and inter-professional awareness of NMAHPs’ research, peer-reviewed publications, and conference presentations. Challenges included a lack of support from line managers, limited value placed on NMAHPs’ research and failure to backfill posts. Conclusion: There were some challenges with the fellowship programme, but all recipients found it to be a positive experience and undertook significant scholarly activity. Implications for practice: A contractual agreement must be established to foster committed partnerships between higher education institutions (HEIs) and the NHS. HEIs and the NHS should conduct frank discussions of the challenges encountered in fellowship programmes. Positive initiatives and outcomes in tertiary education and clinical settings should be shared to improve fellows’ experiences and enhance partnerships between HEIs and the NHS. Job descriptions should include time allocation to review fellowship candidates’ applications regardless of outcome. The showcasing of research successes and the benefits of NMAHP research must evolve to secure organisational ‘buy in’, which is the precursor to widening access to clinical academic pathways

Compression force behaviours: An exploration of the beliefs and values influencing the application of breast compression during screening mammography

This research project investigated the compression behaviours of practitioners during screening mammography. The study sought to provide a qualitative understanding of ‘how’ and ‘why’ practitioners apply compression force. With a clear conflict in the existing literature and little scientific evidence base to support the reasoning behind the application of compression force, this research project investigated the application of compression using a phenomenological approach. Following ethical approval, six focus group interviews were conducted at six different breast screening centres in England. A sample of 41 practitioners were interviewed within the focus groups together with six one-to-one interviews of mammography educators or clinical placement co-ordinators. The findings revealed two broad humanistic and technological categories consisting of 10 themes. The themes included client empowerment, white-lies, time for interactions, uncertainty of own practice, culture, power, compression controls, digital technology, dose audit-safety nets, numerical scales. All of these themes were derived from 28 units of significant meaning (USM). The results demonstrate a wide variation in the application of compression force, thus offering a possible explanation for the difference between practitioner compression forces found in quantitative studies. Compression force was applied in many different ways due to individual practitioner experiences and behaviour. Furthermore, the culture and the practice of the units themselves influenced beliefs and attitudes of practitioners in compression force application. The strongest recommendation to emerge from this study was the need for peer observation to enable practitioners to observe and compare their own compression force practice to that of their colleagues. The findings are significant for clinical practice in order to understand how and why compression force is applied

2D DIGE analysis of maternal plasma for potential biomarkers of Down Syndrome

<p>Abstract</p> <p>Background</p> <p>Prenatal screening for Down Syndrome (DS) would benefit from an increased number of biomarkers to improve sensitivity and specificity. Improving sensitivity and specificity would decrease the need for potentially risky invasive diagnostic procedures.</p> <p>Results</p> <p>We have performed an in depth two-dimensional difference gel electrophoresis (2D DIGE) study to identify potential biomarkers. We have used maternal plasma samples obtained from first and second trimesters from mothers carrying DS affected fetuses compared with mothers carrying normal fetuses. Plasma samples were albumin/IgG depleted and expanded pH ranges of pH 4.5 - 5.5, pH 5.3 - 6.5 and pH 6 - 9 were used for two-dimensional gel electrophoresis (2DE). We found no differentially expressed proteins in the first trimester between the two groups. Significant up-regulation of ceruloplasmin, inter-alpha-trypsin inhibitor heavy chain H4, complement proteins C1s subcomponent, C4-A, C5, and C9 and kininogen 1 were detected in the second trimester in maternal plasma samples where a DS affected fetus was being carried. However, ceruloplasmin could not be confirmed as being consistently up-regulated in DS affected pregnancies by Western blotting.</p> <p>Conclusions</p> <p>Despite the in depth 2DE approach used in this study the results underline the deficiencies of gel-based proteomics for detection of plasma biomarkers. Gel-free approaches may be more productive to increase the number of plasma biomarkers for DS for non-invasive prenatal screening and diagnosis.</p

Polarized Radio Sources: A Study of Luminosity, Redshift and Infrared Colors

The Dominion Radio Astrophysical Observatory Deep Field polarization study has been matched with the Spitzer Wide-Area Infrared Extragalactic survey of the European Large Area Infrared Space Observatory Survey North 1 field. We have used VLA observations with a total intensity rms of 87 microJy beam^-1 to match SWIRE counterparts to the radio sources. Infrared color analysis of our radio sample shows that the majority of polarized sources are elliptical galaxies with an embedded active galactic nucleus. Using available redshift catalogs, we found 429 radio sources of which 69 are polarized with redshifts in the range of 0.04 < z <3.2. We find no correlation between redshift and percentage polarization for our sample. However, for polarized radio sources, we find a weak correlation between increasing percentage polarization and decreasing luminosity.Comment: 35 pages, 12 figures, accepted for publication in The Astrophysical Journa