Positive effects of a chicken eggshell powder-enriched vitamin-mineral supplement on femoral neck bone mineral density in healthy late post-menopausal Dutch women

Although bone metabolism is largely under genetic control, the role of nutrition is considerable. The present study evaluates the effects of chicken eggshell powder, a new source of dietary Ca, and purified CaCO3 on bone mineral density (BMD) of the lumbar spine and hip. Besides BMD we also looked at biochemical markers of bone and Ca metabolism. Both Ca sources were provided in combination with minerals and vitamins including Mg, cholecalciferol and phylloquinone. We designed a randomised, double-blind, placebo-controlled study to take place over 12 months. Healthy Caucasian women (n 85), selected by age (greater than or equal to50 and - 2.5. At baseline, their mean habitual daily Ca intake was adequate. The women were randomly allocated to: eggshell powder-enriched (group A; n 24), purified CaCO3-enriched (group B; n 22), or a placebo product (group C; n 27). BMD was measured at baseline and then after 6 and 12 months of supplementation as were the biochemical markers bone-specific alkaline phosphatase, amino-terminal propeptide extension of type I collagen, deoxypyridinoline, calcitonin, intact parathyroid hormone, calcidiol, and urinary Ca. After 12 months of supplementation, only mean BMD of the femoral neck in group A was significantly increased (P=0.014) by 1.75% (95% CI 0.18, 332) compared with a decrease of -0.60 % (95% CI -1.92, 0.72) in group C. This increase coincided with significant decreases in markers of bone resorption and formation. No significant changes were seen in BMD at other sites, including lumbar spine, nor in groups B and C. No differences were found between groups A and B, or B and C. The present study indicates that healthy late post-menopausal women with an adequate Ca intake at baseline may increase BMD of the hip within 12 months following supplementation with the chicken eggshell powder-enriched supplement

Allemaal andersdenkenden : omgaan met cultuurverschillen /

1ste dr.: 1991.Met register en bibliografi

QChain - integrating social, environmental and economic value: a tool to support innovation in production chains

Today's consumers increasingly demand products that are produced sustainably and ethically. As a result, businesses need to address sustainability and social responsibility issues and find a proper balance between people, planet and profit (PPP) aspects of their production chains. Software tools can play an important role in mapping out the current state of PPP aspects along the production chain, and in the design and evaluation of improvement options. There are indeed many tools that are claimed to be useful for sustainability and social responsibility considerations. Yet, a tool that addresses all three aspects of value creation holistically and facilitates discussion is missing. In this paper we present the development of such a tool, called QChain. The development of this tool was based on ideas from soft systems methodology and inputs from a multidisciplinary team of experts and managers. The tool is intended to support group discussions, particularly during the early stages of innovation processes aimed at improving PPP aspects of production chains. It enables users to visualize the essential elements of the current production chain showing the current PPP values, and explore and compare possible future production chain scenarios and the corresponding PPP values. QChain's visualization helps discussants get a rich appreciation of the current and future scenarios, while the semi-quantitative 'what-if' analysis and scenario comparison enables them to hold objective discussion

Cultural differentiation of negotiating agents

Negotiations proceed differently across cultures. For realistic modeling of agents in multicultural negotiations, the agents must display culturally differentiated behavior. This paper presents an agent-based simulation model that tackles these challenges, based on Hofstede’s model of national cultures. The context is a trade network for goods with a hidden quality attribute. The negotiation model is based on the ABMP negotiation architecture and applies a utility function that includes market value, quality preference and risk attitude. The five dimensions of Hofstede’s model are the basis for the modification of ABMP parameters and weight factors in the utility function. The agents can observe each other’s group membership and status. This information is used, along with the indices of Hofstede’s dimensions, to differentiate behavior in different cultural settings. The paper presents results of test runs that verify the implementation of the model. The model helps to explain behaviors of actors in international trade networks. It proves that Hofstede’s dimensions can be used to generate culturally differentiated agents. Further validations of the model with case studies from literature and experiments have yet to be conducted. Extensions can make this model a useful tool for training traders who engage in cross-cultural negotiation and for implementation in negotiation support systems.Intelligent SystemsElectrical Engineering, Mathematics and Computer Scienc

Institutions and the resilience of biobased production systems: the historical case of livestock intensification in the Netherlands

Disconnects between farming and urban systems are widely seen as impairing the resilience of biobased production systems (BBPSs). However, the institutional mechanisms that underlie these resilience problems are not well understood. In this explorative paper, which integrates elements from institutional and resilience theory, we develop a framework to analyze how institutionally shaped patterns of connects and disconnects affect the resilience of BBPs along the dimensions of robustness, adaptability, and transformability. This framework is applied to the historical case of pig livestock intensification in the Netherlands from 1870 to 2017. The case shows that institutions, successfully established in earlier periods, shape connects and disconnects in subsequent periods, thereby enabling and constraining resilience. A combination of perturbations, institutional layering, and shifts in ideational power is an important institutional mechanism for resilience. We conclude that building resilience requires a variety of reconnecting institutions and refraining from a focus on local reconnects or certification only.status: publishe