The Trillion Dollar Shift

Winner of the Gold Axiom Business Book Award 2019 in the Philanthropy / Non Profit / Sustainability category. Over the past 30 years, the world has seen great social improvements. Technology has been developing at an enormous pace and is helping to solve our most pressing social and environmental challenges. Yet, despite this success, our current model of development is still deeply problematic. Natural disasters triggered by climate change have doubled since the 1980s, violence and armed conflict now cost more than 13 percent of GDP, social inequality and youth unemployment is worsening around the world, and climate change threatens the global population with tremendous environmental as well as social problems. Using the United Nations Sustainable Development Goals as a framework, this book sets out how business and capital now have a real opportunity to help resolve these problems. With clear and plentiful examples and cases of how businesses are making a difference, relevant facts and figures to support the cases, and inspiring and instructional information on how businesses can create sustainable value, this highly readable book is a must-read for businesses (large and small) that wish to genuinely support the delivery of the SDGs. The Paris Climate Agreement and the Sustainable Development Goals (SDGs) drive change and offer a narrative and an opportunity to all to speak in one language on sustainability. They provide us with a clear set of targets for 2030. Through following the SDGs, opportunities abound for business and capital to unlock markets which offer endless potential for profit while at the same time working towards the Sustainable Development Goals. This book illustrates for business how to make the much-needed Trillion Dollar Shift

The Trillion Dollar Shift

Winner of the Gold Axiom Business Book Award 2019 in the Philanthropy / Non Profit / Sustainability category. Over the past 30 years, the world has seen great social improvements. Technology has been developing at an enormous pace and is helping to solve our most pressing social and environmental challenges. Yet, despite this success, our current model of development is still deeply problematic. Natural disasters triggered by climate change have doubled since the 1980s, violence and armed conflict now cost more than 13 percent of GDP, social inequality and youth unemployment is worsening around the world, and climate change threatens the global population with tremendous environmental as well as social problems. Using the United Nations Sustainable Development Goals as a framework, this book sets out how business and capital now have a real opportunity to help resolve these problems. With clear and plentiful examples and cases of how businesses are making a difference, relevant facts and figures to support the cases, and inspiring and instructional information on how businesses can create sustainable value, this highly readable book is a must-read for businesses (large and small) that wish to genuinely support the delivery of the SDGs. The Paris Climate Agreement and the Sustainable Development Goals (SDGs) drive change and offer a narrative and an opportunity to all to speak in one language on sustainability. They provide us with a clear set of targets for 2030. Through following the SDGs, opportunities abound for business and capital to unlock markets which offer endless potential for profit while at the same time working towards the Sustainable Development Goals. This book illustrates for business how to make the much-needed Trillion Dollar Shift

Molecular characteristics of extended-spectrum cephalosporin-resistant Enterobacteriaceae from humans in the community.

To investigate the molecular characteristics of extended-spectrum cephalosporin (ESC)-resistant Enterobacteriaceae collected during a cross-sectional study examining the prevalence and risk factors for faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in humans living in areas with high or low broiler density.ESC-resistant Enterobacteriaceae were identified by combination disc-diffusion test. ESBL/AmpC/carbapenemase genes were analysed using PCR and sequencing. For E. coli, phylogenetic groups and MLST were determined. Plasmids were characterized by transformation and PCR-based replicon typing. Subtyping of plasmids was done by plasmid multilocus sequence typing.175 ESC-resistant Enterobacteriaceae were cultured from 165/1,033 individuals. The isolates were Escherichia coli(n=65), Citrobacter freundii (n=52), Enterobacter cloacae (n=38), Morganella morganii (n=5), Enterobacter aerogenes (n=4), Klebsiella pneumoniae (n=3), Hafnia alvei (n=2), Shigella spp. (n=2), Citrobacter amalonaticus (n=1), Escherichia hermannii (n=1), Kluyvera cryocrescens (n=1), and Pantoea agglomerans (n=1). The following ESBL genes were recovered in 55 isolates originating from 49 of 1,033 (4.7 %) persons: blaCTX-M-1 (n=17), blaCTX-M-15 (n=16), blaCTX-M-14 (n=9), blaCTX-M-2 (n=3), blaCTX-M-3 (n=2), blaCTX-M-24 (n=2), blaCTX-M-27 (n=1), blaCTX-M-32 (n=1), blaSHV-12 (n=2), blaSHV-65 (n=1) and blaTEM-52 (n=1). Plasmidic AmpC (pAmpC) genes were discovered in 6 out of 1,033 (0.6 %) persons. One person carried two different E. coli isolates, one with blaCTX-M-1 and the other with blaCMY-2 and therefore the prevalence of persons carrying Enterobacteriaceae harboring ESBL and/or pAmpC genes was 5.2 %. In eight E. coli isolates the AmpC phenotype was caused by mutations in the AmpC promoter region. No carbapenemase genes were identified. A large variety of E. coli genotypes was found, ST131 and ST10 being most common.ESBL/pAmpC genes resembled those from patients in Dutch hospitals, indicating that healthy humans form a reservoir for transmission of these determinants to vulnerable people. The role of poultry in the transmission to humans in the community remains to be elucidated

The development and validation of testing materials for literacy, numeracy and digital skills in a Dutch context

Besides work-oriented training, most Dutch adult learning courses of formal and non-formal education focus on three basic skills: literacy, numeracy and problem solving in technology-rich environments. In the Netherlands, the Ministry of Education, Culture and Science recently initiated the development of a new adult education framework concerning literacy, numeracy and digital skills. In order to monitor the progress of literacy, numeracy and digital competencies, it is necessary to develop and validate testing materials for specific competencies. This study validates the testing materials which were developed to assess learners’ proficiency in literacy (reading and writing), numeracy and digital skills based on the new Dutch framework. The outcome is that the materials proved valid and can be used in different courses referring to basic skills and adult learning, though there are still some limitations. Besides adult education professionals (such teachers and trainers), policy makers can also use the results of these tests in order to describe and monitor the impact of adult education on the lives of adult learners

Essaybundel RWS Imagine!: hoe kan die nieuwe wereld van big data, veranderde mobiliteit, transformatie van netwerken en duurzame leefomgeving er fysiek uitzien?

In juni 2014 heeft het Bestuur van Rijkswaterstaat aan het Programma Strategische Verkenningen gevraagd een designsessie te organiseren voor de Groepsraad van Rijkswaterstaat. De designsessie moet antwoord geven op de vraag: ‘hoe kan die nieuwe wereld van big data, veranderende mobiliteit, transformatie van de netwerken en een duurzame leefomgeving er fysiek uit zien? En hoe werken we samen in die nieuwe wereld?’ Ter voorbereiding van deze sessie is aan 10 personen, met verschillende expertises, gevraagd een essay te schrijven. Martijn de Waal (onderzoeker Citizen Empowerment aan de HvA) leverde een bijdrage

Genomic comparison of mecC-carrying methicillin-resistant Staphylococcus aureus from hedgehogs and humans in the Netherlands.

OBJECTIVES: MRSA carrying the mecC gene (mecC-MRSA) have been found in humans and animals worldwide. A high carriage rate of mecC-MRSA has been described among hedgehogs in different countries. We performed genomic comparison of mecC-MRSA from hedgehogs and humans using next-generation sequencing (NGS) to investigate possible zoonotic transmission in the Netherlands.METHODS: Nasal swabs from hedgehogs (n = 105) were cultured using pre-enrichment and selective plates. Isolates were sequenced using Illumina NGS platforms. These data were compared with sequence data of mecC-MRSA (n = 62) from the Dutch national MRSA surveillance in humans.RESULTS: Fifty hedgehogs were found to be MRSA positive, of which 48 carried mecC. A total of 60 mecC-MRSA isolates derived from 50 hedgehogs were compared with the human isolates. Fifty-nine mecC-MRSA from hedgehogs and all but one isolate from humans belonged to clonal complexes CC130 and CC1943. The mecC gene was located within the SCCmec XI element. Most mecC-MRSA did not carry other resistance genes besides mecC and blaZ. Two human isolates carried erm(C). Isolates differed in the presence of various virulence genes, which were linked to distinct STs and clonal complexes. Some isolates had up to 17 virulence genes, which underlines their pathogenic potential. No genetic clusters of hedgehog and human isolates were found.CONCLUSIONS: mecC-MRSA from hedgehogs and humans mainly belonged to the same two clonal complexes, indicating a common source. No firm evidence for recent zoonotic transmission was found. Further studies are needed to investigate the role of hedgehogs in the occurrence of mecC-MRSA in humans.</p

Primers used to completely sequence the ESBL/AmpC resistance genes.

<p>Primers used to completely sequence the ESBL/AmpC resistance genes.</p

Characteristics of the ESBL/pAmpC-producing isolates.

<p>^a The first four numbers of the isolate name indicate the person sampled, the number after the underscore indicates the isolate number.</p><p>^b The CTX-M-14 has four synonymous mutations (A372G, G570A, G702A, A875G) in comparison to the official entry for this allele (accession number AF252622).</p><p>^c The TEM-52 gene has one synonymous mutation (C228T) in comparison to the official entry for this TEM allele (accession number Y13612).</p><p>CC = clonal complex; nd = not determined; NTP = non-typeable incompatibility group plasmid.</p><p>Characteristics of the ESBL/pAmpC-producing isolates.</p