Circular 20

Since fanning in Alaska first began and especially since dairy farming became the primary agricultural industry, there has existed a need for hardy legumes which would survive Alaska winters and produce satisfactory yields of high quality forage. To meet this need hundreds of legume species and strains have been introduced during the past 40 or more years. Almost all have lacked the necessary hardiness or have not been satisfactory agronomically. The release of Alaskland red clover in the spring of 1953 is the first time a hardy legume has been made available to growers in Alaska.Cooperating with the United States Department of Agriculture, Agricultural Research Administratio

Evidence of late Quaternary environmental change in a continental east Antarctic lake from lacustrine sedimentary pigment distributions

A sediment core from Progress Lake, one of the oldest lacustrine sequences in East Antarctica, contains distinct zones dating from a previous interglacial (most likely Marine Isotope Stage 5e, c. 125-115 kyr BP) and the present interglacial (Marine Isotope Stage 1), separated by a transition zone representing when the lake became sub-glacial. Profiles of fossil pigments, determined using high performance liquid chromatography and liquid chromatography-tandem mass spectrometry, show distinct differences in the photoautotrophic community during these two interglacial periods. The first was dominated by algae and purple phototrophic bacteria, with periods of photic zone euxinia indicated by pigments from anoxygenic phototrophic bacteria. Specific chlorophyll a derivatives reveal periods when grazing pressure impacted significantly on the phytoplankton community. The virtual absence of pigments in the transition zone reflects severe restriction of photoautotrophic activity, consistent with the take having become sub-glacial. Retreat of snow and ice in the late Holocene (3345 C-14 yr Bp) allowed establishment of a less diverse primary producer community, restricted to algae and cyanobacteria. Grazers were severely restricted and oxidative transformation was more important than during the previous interglacial. The pigment data provide a unique and detailed insight in to the evolution of the lake ecology over an interglacial-glacial-interglacial transition and strong evidence that the Marine Isotope Stage 5e interglacial in this region of coastal East Antarctica was several degrees warmer than at present

Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death

The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches. This is necessary in order to achieve a comprehensive understanding into the mechanisms driving disease initiation and progression, to aid the development of appropriate therapies. In recent decades, the fruit fly Drosophila melanogaster and its associated powerful genetic tools have become a very attractive model system to study tumour-intrinsic and non-tumour-derived processes that mediate tumour development in vivo. In this review, we will summarize recent work on Drosophila as a model system to study cancer biology. We will focus on the interactions between tumours and their microenvironment, including extrinsic mechanisms affecting tumour growth and how tumours impact systemic host physiology

Effect of Photobiomodulation on Vinblastine-Poisoned Murine HERS Cells

Objective: The aim of this study was to investigate the effect of near-infrared (NIR) photobiomodulation on the proliferation and glutathione levels in murine Hertwig\u27s epithelial root sheath (HERS) cells after poisoning with vinblastine. Background: Photobiomodulation has been shown to improve wound healing in a number of animal models. There have been no studies on the effect of photobiomodulation on cancer-related chemotherapy injury to the cells that initiate tooth root growth. Materials and Methods: Control groups consisted of murine HERS cells without vinblastine (VB−) and cells with vinblastine at 10, 20, and 30 ng/mL (VB10, VB20, and VB30). Experimental groups consisted of these same groups with light therapy (VB-L, VB10L, VB20L, and VB30L). The cells were exposed to vinblastine for 1 h. Photobiomodulation consisted of a 75-cm2 gallium-aluminum-arsenide light-emitting diode (LED) array at an energy density of 12.8 J/cm2, delivered with 50 mW/cm2 power over 256 s. Results: Vinblastine alone significantly decreased HERS cell proliferation and glutathione levels at all concentrations (VB10 [−55%, p \u3c 1.0 × 10−8]; VB20 [−72%, p \u3c 1.0 × 10−9]; VB30 [−80%, p \u3c 1.0 × 10−10]; and VB10 [−36%, p \u3c 0.0001]; VB20 [−49%, p \u3c 1.0 × 10−6]; VB30 [−53%, p \u3c 1.0 × 10−7] respectively). Photobiomodulation significantly increased cell proliferation at all levels of vinblastine exposure (VB10L [+50%, p \u3c 0.0001]; VB20L [+45%, p \u3c 0.05]; VB30 [+39%, p \u3c 0.05]) but not of the control (+22%, p  = 0.063). The photobiomodulation significantly increased glutathione production in all concentrations of vinblastine except 20 ng/mL (VB10L [+39%, p = 0.007]; VB20L [+19%, p = 0.087]; VB30 [+14%, p = 0.025]) and the control (+12%, p = 0.13). Conclusions: Photobiomodulation demonstrated an improvement in proliferation and glutathione levels in vinblastine-poisoned murine HERS cells

Management Recommendations for Soybean Aphid (Hemiptera: Aphididae) in the United States

Soybean aphid, Aphis glycines Matsumura (Hemiptera: Aphididae), is the primary pest of soybean, Glycine max L., in the north central region. After more than a decade of research and extension efforts to manage this pest, several consensus management recommendations have been developed for sustainable and profitable soybean production. A summary of integrated pest management (IPM) tactics for soybean aphid are discussed, including cultural, genetic, economic, and chemical controls. To date, sampling and timely foliar insecticides are routinely recommended to protect yield and delay genetic resistance to insecticides. Host plant resistance is a new tool that can regulate populations and reduce the reliance of insecticides to control soybean aphid. A combination of these management tools also will reduce overall production costs and minimize negative environmental effects such as human exposure, and mortality of beneficial insects and other animals

Orientational Ordering and Dynamics of Rodlike Polyelectrolytes

The interplay between electrostatic interactions and orientational correlations is studied for a model system of charged rods positioned on a chain, using Monte Carlo simulation techniques. It is shown that the coupling brings about the notion of {\em electrostatic frustration}, which in turn results in: (i) a rich variety of novel orientational orderings such as chiral phases, and (ii) an inherently slow dynamics characterized by stretched-exponential behavior in the relaxation functions of the system.Comment: 7 pages, 10 figure

Force modelling of the crankshaft pin grinding process.

A force model was developed for crankshaft pin grinding to predict the forces generated during grinding. The force model developed builds on the authors&rsquo; previously developed model, which predicted the out-of-roundness in crankshaft pin grinding. The model includes key grinding variables, such as the work removal parameter (WRP), system sti€ ness and Young&rsquo;s modulus to determine the end forces produced. The model also includes the important geometrical relationships that are unique to this type of grinding. The model was veriŽ ed using an experiential set-up involving sophisticated strain gauge force measurements on a commercial Landis CP grinding machine, with close correlation between the results and the model.<br /