Terra incognita—cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia

Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioral variant frontotemporal dementia (bvFTD), a disease which is characterized by cognitive and neuropsychiatric deficits. The present study assessed whether degeneration in specific cerebellar subregions associate with indices of cognition and neuropsychiatric performance in bvFTD. Our results demonstrate a relationship between cognitive and neuropsychiatric decline across various domains of memory, language, emotion, executive, visuospatial function, and motivation and the degree of gray matter degeneration in cerebellar lobules V–VII. Most notably, bilateral cerebellar lobule VII and the posterior vermis emerged as distinct for memory processes, the right cerebellar hemisphere underpinned emotion, and the posterior vermis was highlighted in language dysfunction in bvFTD. Based on cortico-cerebellar connectivity maps, these findings in the cerebellum are consistent with the neural connections with the cortices involved in these domains in patients with bvFTD. Overall, the present study underscores the significance of cortical-cerebellar networks associated with cognition and neuropsychiatric dysfunction in bvFTD

One-Particle Excitation of the Two-Dimensional Hubbard Model

The real part of the self-energy of interacting two-dimensional electrons has been calculated in the t-matrix approximation. It is shown that the forward scattering results in an anomalous term leading to the vanishing renormalization factor of the one-particle Green function, which is a non-perturbative effect of the interaction U. The present result is a microscopic demonstration of the claim by Anderson based on the conventional many-body theory. The effect of the damping of the interacting electrons, which has been ignored in reaching above conclusion, has been briefly discussed.Comment: 7 pages, LaTeX, 1 figure, uses jpsj.sty, to be published in J. Phys. Soc. Jpn. 66 No. 3 (1997

Laboratory measurements and theoretical calculations of O_2 A band electric quadrupole transitions

Frequency-stabilized cavity ring-down spectroscopy was utilized to measure electric quadrupole transitions within the ^(16)O_2 A band, b^1Σ^+_g ← X^3Σ^-_g(0,0). We report quantitative measurements (relative uncertainties in intensity measurements from 4.4% to 11%) of nine ultraweak transitions in the ^NO, ^PO, ^RS, and ^TS branches with line intensities ranging from 3×10^(−30) to 2×10^(−29) cm molec.^(−1). A thorough discussion of relevant noise sources and uncertainties in this experiment and other cw-cavity ring-down spectrometers is given. For short-term averaging (t<100 s), we estimate a noise-equivalent absorption of 2.5×10^(−10) cm^(−1) Hz^(−1/2). The detection limit was reduced further by co-adding up to 100 spectra to yield a minimum detectable absorption coefficient equal to 1.8×10^(−11) cm^(−1), corresponding to a line intensity of ~2.5×10^(−31) cm molec.^(−1). We discuss calculations of electric quadrupole line positions based on a simultaneous fit of the ground and upper electronic state energies which have uncertainties <3 MHz, and we present calculations of electric quadrupole matrix elements and line intensities. The electric quadrupole line intensity calculations and measurements agreed on average to 5%, which is comparable to our average experimental uncertainty. The calculated electric quadrupole band intensity was 1.8(1)×10^(−27) cm molec.−1 which is equal to only ~8×10^(−6) of the magnetic dipole band intensity

Braneworld inflation from an effective field theory after WMAP three-year data

In light of the results from the WMAP three-year sky survey, we study an inflationary model based on a single-field polynomial potential, with up to quartic terms in the inflaton field. Our analysis is performed in the context of the Randall-Sundrum II braneworld theory, and we consider both the high-energy and low-energy (i.e. the standard cosmology case) limits of the theory. We examine the parameter space of the model, which leads to both large-field and small-field inflationary type solutions. We conclude that small field inflation, for a potential with a negative mass square term, is in general favored by current bounds on the tensor-to-scalar perturbation ratio rs.Comment: 11 pages, 5 figures; references updated and a few comments added; final version to appear in Phys. Rev.

A critical assessment of the long term changes in the wintertime surface Arctic Oscillation and Northern Hemisphere storminess in the ERA20C reanalysis

This study investigates the robustness of the long-term changes in the wintertime surface Arctic Oscillation (AO) in the ERA20C reanalysis. A statistically significant trend in the AO is found in ERA20C over the period 1900-2010. These long-term changes in the AO are not found in two other observational datasets. The long term change in the AO in ERA20C is associated with statistically significant negative trend (approximately -6hPa per century) in mean-sea level pressure (MSLP) over the Northern Hemisphere (NH) polar regions. This is not seen in the HADSLP2 observational dataset, suggesting that the trends in the ERA20C AO index may be spurious. The spurious long term changes in MSLP and the AO index in ERA20C result in a strengthening of the meridional MSLP gradient in ERA20C. The strengthening of the meridional MSLP gradient is consistent with increases in wintertime storminess in Northern Europe and the NH high latitudes

A logic road from special relativity to general relativity

We present a streamlined axiom system of special relativity in first-order logic. From this axiom system we "derive" an axiom system of general relativity in two natural steps. We will also see how the axioms of special relativity transform into those of general relativity. This way we hope to make general relativity more accessible for the non-specialist

The role of serial European windstorm clustering for extreme seasonal losses as determined from multi-centennial simulations of high resolution global climate model data

Extratropical cyclones are the most damaging natural hazard to affect western Europe. Serial clustering occurs when many intense cyclones affect one specific geographic region in a short period of time which can potentially lead to very large seasonal losses. Previous studies have shown that intense cyclones may be more likely to cluster than less intense cyclones. We revisit this topic using a high resolution climate model with the aim to determine how important clustering is for windstorm related losses. The role of windstorm clustering is investigated using a quantifiable metric (storm severity index, SSI) that is based on near surface meteorological variables (10-metre wind speed) and is a good proxy for losses. The SSI is used to convert a wind footprint into losses for individual windstorms or seasons. 918 years of a present-day ensemble of coupled climate model simulations from the High-Resolution Global Environment Model (HiGEM) are compared to ERA-Interim re-analysis. HiGEM is able to successfully reproduce the wintertime North Atlantic/European circulation, and represent the large-scale circulation associated with the serial clustering of European windstorms. We use two measures to identify any changes in the contribution of clustering to the seasonal windstorm loss as a function of return period. Above a return period of 3 years, the accumulated seasonal loss from HiGEM is up to 20% larger than the accumulated seasonal loss from a set of random resamples of the HiGEM data. Seasonal losses are increased by 10-20% relative to randomised seasonal losses at a return period of 200 years. The contribution of the single largest event in a season to the accumulated seasonal loss does not change with return period, generally ranging between 25-50%. Given the realistic dynamical representation of cyclone clustering in HiGEM, and comparable statistics to ERA-Interim, we conclude that our estimation of clustering and its dependence on the return period will be useful for informing the development of risk models for European windstorms, particularly for longer return periods

Tomographic imaging and scanning thermal microscopy: thermal impedance tomography

The application of tomographic imaging techniques developed for medical applications to the data provided by the scanning thermal microscope will give access to true three-dimensional information on the thermal properties of materials on a mm length scale. In principle, the technique involves calculating and inverting a sensitivity matrix for a uniform isotropic material, collecting ordered data at several modulation frequencies, and multiplying the inverse of the matrix with the data vector. In practice, inversion of the matrix in impractical, and a novel iterative technique is used. Examples from both simulated and real data are given

Experimental Implementation of Logical Bell State Encoding

Liquid phase NMR is a general purpose test-bed for developing methods of coherent control relevant to quantum information processing. Here we extend these studies to the coherent control of logical qubits and in particular to the unitary gates necessary to create entanglement between logical qubits. We report an experimental implementation of a conditional logical gate between two logical qubits that are each in decoherence free subspaces that protect the quantum information from fully correlated dephasing.Comment: 9 Pages, 5 Figure

Quasi-Particles in Two-Dimensional Hubbard Model: Splitting of Spectral Weight

It is shown that the energy $(\varepsilon)$ and momentum $(k)$ dependences of the electron self-energy function $\Sigma (k, \varepsilon + i0) \equiv \Sigma^{R}(k, \varepsilon)$ are, ${\rm Im} \Sigma^{R} (k, \varepsilon) = -a\varepsilon^{2}|\varepsilon - \xi_{k}|^{- \gamma (k)}$ where $a$ is some constant, $\xi_{k} = \varepsilon(k)-\mu, \varepsilon(k)$ being the band energy, and the critical exponent $\gamma(k)$, which depends on the curvature of the Fermi surface at $k$, satisfies, $0 \leq \gamma(k) \leq 1$. This leads to a new type of electron liquid, which is the Fermi liquid in the limit of $\varepsilon, \xi_{k} \rightarrow 0$ but for $\xi_{k} \neq 0$ has a split one-particle spectra as in the Tomonaga-Luttinger liquid.Comment: 8 pages (LaTeX) 4 figures available upon request will be sent by air mail. KomabaCM-preprint-O