Welding mild steel

n/

Experiments on Chemical Control of Behavior in Brown Tree Snakes

The brown tree snake (Boiga irregularis), accidentally introduced on Guam shortly after World War 11, is the target of extensive efforts aimed at reducing populations and preventing their spread to other Pacific islands. Chemical attractants and repellents have been investigated, and this paper presents an overview of current knowledge. In particular, chemical cues that have strong effects in laboratory tests have had only modest (though significant) effects in field tests on Guam. Reasons for the different outcomes of laboratory and field studies are discussed along with recommendations for the redesign of laboratory experiments

Topological phase separation in 2D hard-core Bose-Hubbard system away from half-filling

We suppose that the doping of the 2D hard-core boson system away from half-filling may result in the formation of multi-center topological defect such as charge order (CO) bubble domain(s) with Bose superfluid (BS) and extra bosons both localized in domain wall(s), or a {\it topological} CO+BS {\it phase separation}, rather than an uniform mixed CO+BS supersolid phase. Starting from the classical model we predict the properties of the respective quantum system. The long-wavelength behavior of the system is believed to remind that of granular superconductors, CDW materials, Wigner crystals, and multi-skyrmion system akin in a quantum Hall ferromagnetic state of a 2D electron gas.Comment: 6 pages, 1 figur

Low Temperature Static and Dynamic Behavior of the Two-Dimensional Easy-Axis Heisenberg Model

We apply the self-consistent harmonic approximation (SCHA) to study static and dynamic properties of the two-dimensional classical Heisenberg model with easy-axis anisotropy. The static properties obtained are magnetization and spin wave energy as functions of temperature, and the critical temperature as a function of the easy-axis anisotropy. We also calculate the dynamic correlation functions using the SCHA renormalized spin wave energy. Our analytical results, for both static properties and dynamic correlation functions, are compared to numerical simulation data combining cluster-Monte Carlo algorithms and Spin Dynamics. The comparison allows us to conclude that far below the transition temperature, where the SCHA is valid, spin waves are responsible for all relevant features observed in the numerical simulation data; topological excitations do not seem to contribute appreciably. For temperatures closer to the transition temperature, there are differences between the dynamic correlation functions from SCHA theory and Spin Dynamics; these may be due to the presence of domain walls and solitons.Comment: 12 pages, 14 figure

From Effective Lagrangians, to Chiral Bags, to Skyrmions with the Large-N_c Renormalization Group

We explicitly relate effective meson-baryon Lagrangian models, chiral bags, and Skyrmions in the following way. First, effective Lagrangians are constructed in a manner consistent with an underlying large-N_c QCD. An infinite set of graphs dress the bare Yukawa couplings at *leading* order in 1/N_c, and are summed using semiclassical techniques. What emerges is a picture of the large-N_c baryon reminiscent of the chiral bag: hedgehog pions for r > 1/\Lambda patched onto bare nucleon degrees of freedom for r < 1/\Lambda, where the ``bag radius'' 1/\Lambda is the UV cutoff on the graphs. Next, a novel renormalization group (RG) is derived, in which the bare Yukawa couplings, baryon masses and hyperfine baryon mass splittings run with \Lambda. Finally, this RG flow is shown to act as a *filter* on the renormalized Lagrangian parameters: when they are fine-tuned to obey Skyrme-model relations the continuum limit \Lambda --> \infty exists and is, in fact, a Skyrme model; otherwise there is no continuum limit.Comment: Figures included (separate file). This ``replaced'' version corrects the discussion of backwards-in-time baryon

Static solitons with non-zero Hopf number

We investigate a generalized non-linear O(3) $\sigma$-model in three space dimensions where the fields are maps $S^3 \mapsto S^2$. Such maps are classified by a homotopy invariant called the Hopf number which takes integer values. The model exhibits soliton solutions of closed vortex type which have a lower topological bound on their energies. We explicitly compute the fields for topological charge 1 and 2 and discuss their shapes and binding energies. The effect of an additional potential term is considered and an approximation is given for the spectrum of slowly rotating solitons.Comment: 13 pages, RevTeX, 7 Postscript figures, minor changes have been made, a reference has been corrected and a figure replace

The Ontology of Intentional Agency in Light of Neurobiological Determinism: Philosophy Meets Folk Psychology

The moot point of the Western philosophical rhetoric about free will consists in examining whether the claim of authorship to intentional, deliberative actions fits into or is undermined by a one-way causal framework of determinism. Philosophers who think that reconciliation between the two is possible are known as metaphysical compatibilists. However, there are philosophers populating the other end of the spectrum, known as the metaphysical libertarians, who maintain that claim to intentional agency cannot be sustained unless it is assumed that indeterministic causal processes pervade the action-implementation apparatus employed by the agent. The metaphysical libertarians differ among themselves on the question of whether the indeterministic causal relation exists between the series of intentional states and processes, both conscious and unconscious, and the action, making claim for what has come to be known as the event-causal view, or between the agent and the action, arguing that a sort of agent causation is at work. In this paper, I have tried to propose that certain features of both event-causal and agent-causal libertarian views need to be combined in order to provide a more defendable compatibilist account accommodating deliberative actions with deterministic causation. The ‘‘agent-executed-eventcausal libertarianism’’, the account of agency I have tried to develop here, integrates certain plausible features of the two competing accounts of libertarianism turning them into a consistent whole. I hope to show in the process that the integration of these two variants of libertarianism does not challenge what some accounts of metaphysical compatibilism propose—that there exists a broader deterministic relation between the web of mental and extra-mental components constituting the agent’s dispositional system—the agent’s beliefs, desires, short-term and long-term goals based on them, the acquired social, cultural and religious beliefs, the general and immediate and situational environment in which the agent is placed, etc. on the one hand and the decisions she makes over her lifetime on the basis of these factors. While in the ‘‘Introduction’’ the philosophically assumed anomaly between deterministic causation and the intentional act of deciding has been briefly surveyed, the second section is devoted to the task of bridging the gap between compatibilism and libertarianism. The next section of the paper turns to an analysis of folk-psychological concepts and intuitions about the effects of neurochemical processes and prior mental events on the freedom of making choices. How philosophical insights can be beneficially informed by taking into consideration folk-psychological intuitions has also been discussed, thus setting up the background for such analysis. It has been suggested in the end that support for the proposed theory of intentional agency can be found in the folk-psychological intuitions, when they are taken in the right perspective

The size of the treatment effect: do patients and proxies agree?

Background: This study examined whether MS patients and proxy respondents agreed on change in disease impact, which was induced by treatment. This may be of interest in situations when patients suffer from limitations that interfere with reliable self-assessment, such as cognitive impairment.Methods: MS patients and proxies completed the Multiple Sclerosis Impact Scale (MSIS-29) before and after intravenous steroid treatment. Analyses focused on patient-proxy agreement between MSIS-29 change scores. Transition ratings were used to measure the patient's judgement of change and whether this change was reflected in the MSIS-29 change of patients and proxies. Receiver operating characteristic (ROC) analyses were also performed to examine the diagnostic properties of the MSIS-29 when completed by patients and proxies.Results: 42 patients and proxy respondents completed the MSIS-29 at baseline and follow-up. Patient-proxy differences between change scores on the physical and psychological MSIS-29 subscale were quite small, although large variability was found. The direction of mean change was in concordance with the transition ratings of the patients. Results of the ROC analyses of the MSIS-29 were similar when completed by patients (physical scale: AUC = 0.79, 95% CI: 0.65 - 0.93 and 0.66, 95% CI: 0.48 - 0.84 for the psychological scale) and proxies (physical scale: 0.80, 95% CI: 0.72 - 0.96 and 0.71, 95% CI: 0.56 - 0.87 for the psychological scale)Conclusion: Although the results need to be further explored in larger samples, these results do point towards possible use of proxy respondents to assess patient perceived treatment change at the group level

Genome Rearrangements Detected by SNP Microarrays in Individuals with Intellectual Disability Referred with Possible Williams Syndrome

Intellectual disability (ID) affects 2-3% of the population and may occur with or without multiple congenital anomalies (MCA) or other medical conditions. Established genetic syndromes and visible chromosome abnormalities account for a substantial percentage of ID diagnoses, although for approximately 50% the molecular etiology is unknown. Individuals with features suggestive of various syndromes but lacking their associated genetic anomalies pose a formidable clinical challenge. With the advent of microarray techniques, submicroscopic genome alterations not associated with known syndromes are emerging as a significant cause of ID and MCA.High-density SNP microarrays were used to determine genome wide copy number in 42 individuals: 7 with confirmed alterations in the WS region but atypical clinical phenotypes, 31 with ID and/or MCA, and 4 controls. One individual from the first group had the most telomeric gene in the WS critical region deleted along with 2 Mb of flanking sequence. A second person had the classic WS deletion and a rearrangement on chromosome 5p within the Cri du Chat syndrome (OMIM:123450) region. Six individuals from the ID/MCA group had large rearrangements (3 deletions, 3 duplications), one of whom had a large inversion associated with a deletion that was not detected by the SNP arrays.Combining SNP microarray analyses and qPCR allowed us to clone and sequence 21 deletion breakpoints in individuals with atypical deletions in the WS region and/or ID or MCA. Comparison of these breakpoints to databases of genomic variation revealed that 52% occurred in regions harboring structural variants in the general population. For two probands the genomic alterations were flanked by segmental duplications, which frequently mediate recurrent genome rearrangements; these may represent new genomic disorders. While SNP arrays and related technologies can identify potentially pathogenic deletions and duplications, obtaining sequence information from the breakpoints frequently provides additional information

A systematic review of biomarkers for disease progression in Parkinson's disease

Peer reviewedPublisher PD