436 research outputs found
âsome kind of thing it aint us but yet its in usâ: David Mitchell, Russell Hoban, and metafiction after the millennium
This article appraises the debt that David Mitchellâs Cloud Atlas owes to the novels of Russell Hoban, including, but not limited to, Riddley Walker. After clearly mapping a history of Hobanâs philosophical perspectives and Mitchellâs inter-textual genre-impersonation practice, the article assesses the degree to which Mitchellâs metatextual methods indicate a nostalgia for by-gone radical aesthetics rather than reaching for new modes of its own. The article not only proposes several new backdrops against which Mitchellâs novel can be read but also conducts the first in-depth appraisal of Mitchellâs formal linguistic replication of Riddley Walker
Readings in program control
Under the heading of Program Control, a number of related topics are discussed: cost estimating methods; planning and scheduling; cost overruns in the defense industry; the history of estimating; the advantages of cost plus award fee contracts; and how program control techniques led to the success of a NASA development project
Non-adaptive Measurement-based Quantum Computation and Multi-party Bell Inequalities
Quantum correlations exhibit behaviour that cannot be resolved with a local
hidden variable picture of the world. In quantum information, they are also
used as resources for information processing tasks, such as Measurement-based
Quantum Computation (MQC). In MQC, universal quantum computation can be
achieved via adaptive measurements on a suitable entangled resource state. In
this paper, we look at a version of MQC in which we remove the adaptivity of
measurements and aim to understand what computational abilities still remain in
the resource. We show that there are explicit connections between this model of
computation and the question of non-classicality in quantum correlations. We
demonstrate this by focussing on deterministic computation of Boolean
functions, in which natural generalisations of the Greenberger-Horne-Zeilinger
(GHZ) paradox emerge; we then explore probabilistic computation, via which
multipartite Bell Inequalities can be defined. We use this correspondence to
define families of multi-party Bell inequalities, which we show to have a
number of interesting contrasting properties.Comment: 13 pages, 4 figures, final version accepted for publicatio
Issues in NASA program and project management
This volume is the ninth in an ongoing series on aerospace project management at NASA. Articles in this volume cover evolution of NASA cost estimating; SAM 2; National Space Science Program: strategies to maximize science return; and human needs, motivation, and results of the NASA culture surveys. A section on resources for NASA managers rounds out the publication
Individualized outcome prognostication for patients with laryngeal cancer
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142424/1/cncr31087.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142424/2/cncr31087_am.pd
Evidence-Based Professional Development of Science Teachers in Two Countries
The focus of this collaborative research project of King?s College London, and the Weizmann Institute, Israel. project is on investigating the ways in which teachers can demonstrate accomplished teaching in a specific domain of science and on the teacher learning that is generated through continuing professional development programs (CPD) that lead towards such practice. The interest lies in what processes and inputs are required to help secondary school science teachers develop expertise in a specific aspect of science teaching. `It focuses on the design of the CPD programmes and examines the importance of an evidence-based approach through portfolioconstruction in which professional dialogue pathes the way for teacher learning. The set of papers highlight the need to set professional challenge while tailoring CPD to teachers? needs to create the environment in which teachers can advance and transform their practice. The cross-culture perspective added to the richness of the development and enabled the researchers to examine which aspects were fundamental to the design by considering similarities and differences between the domains
Easing into the Academy: Using Technology to Foster Cross-Institutional Critical Friendships
This article addresses the ways in which early career teacher educators can support each other as they enter the academic community. By utilizing technology as an instrument to engage in a cross-country critical friendship, the authors were able to engage in a dialogue that grew out of mutual interests and concerns. Through critical reflection, they were able to address the question: How can we, two early-career teacher educators, push ourselves and one another to more critically examine our teaching practices? In doing so, each ânew educatorâ grew more confident in claiming one\u27s voice as a sustainable critical friendship emerged
A compendium and functional characterization of mammalian genes involved in adaptation to Arctic or Antarctic environments
Many mammals are well adapted to surviving in extremely cold environments. These species have likely accumulated genetic changes that help them efficiently cope with low temperatures. It is not known whether the same genes related to cold adaptation in one species would be under selection in another species. The aims of this study therefore were: to create a compendium of mammalian genes related to adaptations to a low temperature environment; to identify genes related to cold tolerance that have been subjected to independent positive selection in several species; to determine promising candidate genes/pathways/organs for further empirical research on cold adaptation in mammals
The crystal structure of human Rogdi provides insight into the causes of Kohlschutter-Tonz Syndrome
Kohlschutter-Tönz syndrome (KTS) is a rare autosomal-recessive disorder of childhood onset characterized by global developmental delay, spasticity, epilepsy, and amelogenesis imperfecta. Rogdi, an essential protein, is highly conserved across metazoans, and mutations in Rogdi are linked to KTS. However, how certain mutations in Rogdi abolish its physiological functions and cause KTS is not known. In this study, we determined the crystal structure of human Rogdi protein at atomic resolution. Rogdi forms a novel elongated curved structure comprising the ?? domain, a leucine-zipper-like four-helix bundle, and a characteristic ??-sheet domain. Within the ?? domain, the N-terminal H1 helix (residues 19-45) pairs with the C-terminal H6 helix (residues 252-287) in an antiparallel manner, indicating that the integrity of the four-helix bundle requires both N- and C-terminal residues. The crystal structure, in conjunction with biochemical data, indicates that the ?? domain might undergo a conformational change and provide a structural platform for protein-protein interactions. Disruption of the four-helix bundle by mutation results in significant destabilization of the structure. This study provides structural insights into how certain mutations in Rogdi affect its structure and cause KTS, which has important implications for the development of pharmaceutical agents against this debilitating neurological disease
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