426 research outputs found
The role of Schizosaccharomyces pombe SUMO ligases in genome stability
SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is likely to be important. Control of the levels of SUMOylation is brought about through a balance of conjugating and deconjugating activities, i.e. of SUMO (small ubiquitin-related modifier) conjugators and ligases versus SUMO proteases. Although conjugation of SUMO to proteins can occur in the absence of a SUMO ligase, it is apparent that SUMO ligases facilitate the SUMOylation of specific subsets of proteins. Two SUMO ligases in Schizosaccharomyces pombe, Pli1 and Nse2, have been identified, both of which have roles in genome stability. We report here on a comparison between the properties of the two proteins and discuss potential roles for the proteins
Study of heterogeneous nucleation of eutectic Si in high-purity Al-Si alloys with Sr addition
The official published version can be accessed from the link below - Copyright @ 2010 The Minerals, Metals & Materials Society and ASM InternationalAl-5 wt pct Si master-alloys with controlled Sr and/or P addition/s were produced using super purity Al 99.99 wt pct and Si 99.999 wt pct materials in an arc melter. The master-alloy was melt-spun resulting in the production of thin ribbons. The Al matrix of the ribbons contained entrained Al-Si eutectic droplets that were subsequently investigated. Differential scanning calorimetry, thermodynamic calculations, and transmission electron microscopy techniques were employed to examine the effect of the Sr and P additions on eutectic undercoolings and nucleation phenomenon. Results indicate that, unlike P, Sr does not promote nucleation. Increasing Sr additions depressed the eutectic nucleation temperature. This may be a result of the formation of a Sr phase that could consume or detrimentally affect potent AlP nucleation sites.This work is financially supported by the
Higher Education Commission of Pakistan and managerially supported from the OAD
N=8 superconformal gauge theories and M2 branes
Based on recent developments, in this letter we find 2+1 dimensional gauge
theories with scale invariance and N=8 supersymmetry. The gauge theories are
defined by a Lagrangian and are based on an infinite set of 3-algebras,
constructed as an extension of ordinary Lie algebras. Recent no-go theorems on
the existence of 3-algebras are circumvented by relaxing the assumption that
the invariant metric is positive definite. The gauge group is non compact, and
its maximally compact subgroup can be chosen to be any ordinary Lie group,
under which the matter fields are adjoints or singlets. The theories are parity
invariant and do not admit any tunable coupling constant. In the case of SU(N)
the moduli space of vacua contains a branch of the form (R^8)^N/S_N. These
properties are expected for the field theory living on a stack of M2 branes.Comment: 14 pages, no figure
Three-dimensional N=8 conformal supergravity and its coupling to BLG M2-branes
This paper is concerned with the problem of coupling the N=8 superconformal
Bagger-Lambert-Gustavsson (BLG) theory to N=8 conformal supergravity in three
dimensions. We start by constructing the on-shell N=8 conformal supergravity in
three dimensions consisting of a Chern-Simons type term for each of the gauge
fields: the spin connection, the SO(8) R-symmetry gauge field and the spin 3/2
Rarita-Schwinger (gravitino) field. We then proceed to couple this theory to
the BLG theory. The final theory should have the same physical content, i.e.,
degrees of freedom, as the ordinary BLG theory. We discuss briefly the
properties of this "topologically gauged" BLG theory and why this theory may be
useful.Comment: 20 pages, v2: references and comments added, presentation in section
3.2 extended. v3: misprints and a sign error corrected, version published in
JHE
Multipole interaction between atoms and their photonic environment
Macroscopic field quantization is presented for a nondispersive photonic
dielectric environment, both in the absence and presence of guest atoms.
Starting with a minimal-coupling Lagrangian, a careful look at functional
derivatives shows how to obtain Maxwell's equations before and after choosing a
suitable gauge. A Hamiltonian is derived with a multipolar interaction between
the guest atoms and the electromagnetic field. Canonical variables and fields
are determined and in particular the field canonically conjugate to the vector
potential is identified by functional differentiation as minus the full
displacement field. An important result is that inside the dielectric a dipole
couples to a field that is neither the (transverse) electric nor the
macroscopic displacement field. The dielectric function is different from the
bulk dielectric function at the position of the dipole, so that local-field
effects must be taken into account.Comment: 17 pages, to be published in Physical Review
Constraining Maximally Supersymmetric Membrane Actions
We study the recent construction of maximally supersymmetric field theory
Lagrangians in three spacetime dimensions that are based on algebras with a
triple product. Assuming that the algebra has a positive definite metric
compatible with the triple product, we prove that the only non-trivial examples
are either the well known case based on a four dimensional algebra or direct
sums thereof.Comment: 11 pages, very minor changes. Reference added. Version to be
published in JHE
Burkholderia multivorans septicemia in a pediatric liver transplant patient
“Cepacia syndrome”, caused by Burkholderia cepacia complex and often associated with cystic fibrosis, carries a high mortality rate. It is rare for Burkholderia multivorans, a species within the B. cepacia complex, to cause cepacia syndrome even among patients with cystic fibrosis. This is the first reported fatal case of cepacia syndrome caused by B. multivorans occurring in a pediatric liver transplant recipient who does not have cystic fibrosis. We describe the unique characteristics of this pathogen among the non–cystic fibrosis population and the importance of early recognition and treatment
Spontaneous decay in the presence of dispersing and absorbing bodies: general theory and application to a spherical cavity
A formalism for studying spontaneous decay of an excited two-level atom in
the presence of dispersing and absorbing dielectric bodies is developed. An
integral equation, which is suitable for numerical solution, is derived for the
atomic upper-state-probability amplitude. The emission pattern and the power
spectrum of the emitted light are expressed in terms of the Green tensor of the
dielectric-matter formation including absorption and dispersion. The theory is
applied to the spontaneous decay of an excited atom at the center of a
three-layered spherical cavity, with the cavity wall being modeled by a
band-gap dielectric of Lorentz type. Both weak coupling and strong coupling are
studied, the latter with special emphasis on the cases where the atomic
transition is (i) in the normal-dispersion zone near the medium resonance and
(ii) in the anomalous-dispersion zone associated with the band gap. In a
single-resonance approximation, conditions of the appearance of Rabi
oscillations and closed solutions to the evolution of the atomic state
population are derived, which are in good agreement with the exact numerical
results.Comment: 12 pages, 6 figures, typos fixed, 1 figure adde
A lattice model for the kinetics of rupture of fluid bilayer membranes
We have constructed a model for the kinetics of rupture of membranes under
tension, applying physical principles relevant to lipid bilayers held together
by hydrophobic interactions. The membrane is characterized by the bulk
compressibility (for expansion), the thickness of the hydrophobic part of the
bilayer, the hydrophobicity and a parameter characterizing the tail rigidity of
the lipids. The model is a lattice model which incorporates strain relaxation,
and considers the nucleation of pores at constant area, constant temperature,
and constant particle number. The particle number is conserved by allowing
multiple occupancy of the sites. An equilibrium ``phase diagram'' is
constructed as a function of temperature and strain with the total pore surface
and distribution as the order parameters. A first order rupture line is found
with increasing tension, and a continuous increase in proto-pore concentration
with rising temperature till instability. The model explains current results on
saturated and unsaturated PC lipid bilayers and thicker artificial bilayers
made of diblock copolymers. Pore size distributions are presented for various
values of area expansion and temperature, and the fractal dimension of the pore
edge is evaluated.Comment: 15 pages, 8 figure
Atom trapping and two-dimensional Bose-Einstein condensates in field-induced adiabatic potentials
We discuss a method to create two-dimensional traps as well as atomic shell,
or bubble, states for a Bose-Einstein condensate initially prepared in a
conventional magnetic trap. The scheme relies on the use of time-dependent,
radio frequency-induced adiabatic potentials. These are shown to form a
versatile and robust tool to generate novel trapping potentials. Our shell
states take the form of thin, highly stable matter-wave bubbles and can serve
as stepping-stones to prepare atoms in highly-excited trap eigenstates or to
study `collapse and revival phenomena'. Their creation requires gravitational
effects to be compensated by applying additional optical dipole potentials.
However, in our scheme gravitation can also be exploited to provide a route to
two-dimensional atom trapping. We demonstrate the loading process for such a
trap and examine experimental conditions under which a 2D condensate may be
prepared.Comment: 16 pages, 10 figure
- …