21 research outputs found

    Convenient Solution-Phase Synthesis and Conformational Studies of Novel Linear and Cyclic a,ß-Alternating Peptoids

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    The synthesis of a novel family of peptidomimetics composed of linear and cyclic ?,?-alternating peptoids is described. Oligomers consisting of up to six peptoid residues (n = 1?3) were synthesized on large scale with use of an efficient iterative solution-phase method and longer oligomers (n = 4, 5) were obtained by the coupling of appropriately protected shorter oligomers. Preliminary conformational studies of these hybrid peptoids are reported
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