Structural and Dynamical Properties of Galaxies in a Hierarchical Universe: Sizes and Specific Angular Momenta

We use a state-of-the-art semi-analytic model to study the size and the specific angular momentum of galaxies. Our model includes a specific treatment for the angular momentum exchange between different galactic components. Disk scale radii are estimated from the angular momentum of the gaseous/stellar disk, while bulge sizes are estimated assuming energy conservation. The predicted size--mass and angular momentum--mass relations are in fair agreement with observational measurements in the local Universe, provided a treatment for gas dissipation during major mergers is included. Our treatment for disk instability leads to unrealistically small radii of bulges formed through this channel, and predicts an offset between the size--mass relations of central and satellite early-type galaxies, that is not observed. The model reproduces the observed dependence of the size--mass relation on morphology, and predicts a strong correlation between specific angular momentum and cold gas content. This correlation is a natural consequence of galaxy evolution: gas-rich galaxies reside in smaller halos, and form stars gradually until present day, while gas-poor ones reside in massive halos, that formed most of their stars at early epochs, when the angular momentum of their parent halos is low. The dynamical and structural properties of galaxies can be strongly affected by a different treatment for stellar feedback, as this would modify their star formation history. A higher angular momentum for gas accreted through rapid mode does not affect significantly the properties of massive galaxies today, but has a more important effect on low-mass galaxies at higher redshift.Comment: 26 pages, 14 figures, 4 appendices. Accepted for publication in MNRA

The Evolution of Sizes and Specific Angular Momenta in Hierarchical Models of Galaxy Formation and Evolution

We extend our previous work focused at $z\sim0$, studying the redshift evolution of galaxy dynamical properties using the state-of-the-art semi-analytic model GAEA: we show that the predicted size-mass relation for disky/star forming and quiescent galaxies is in good agreement with observational estimates, up to $z\sim2$. Bulge dominated galaxies have sizes that are offset low with respect to observational estimates, mainly due to our implementation of disk instability at high redshift. At large masses, both quiescent and bulge dominated galaxies have sizes smaller than observed. We interpret this as a consequence of our most massive galaxies having larger gas masses than observed, and therefore being more affected by dissipation. We argue that a proper treatment of quasar driven winds is needed to alleviate this problem. Our model compact galaxies have number densities in agreement with observational estimates and they form most of their stars in small and low angular momentum high-$z$ halos. GAEA predicts that a significant fraction of compact galaxies forming at high-$z$ is bound to merge with larger structures at lower redshifts: therefore they are not the progenitors of normal-size passive galaxies at $z=0$. Our model also predicts a stellar-halo size relation that is in good agreement with observational estimates. The ratio between stellar size and halo size is proportional to the halo spin and does not depend on stellar mass but for the most massive galaxies, where AGN feedback leads to a significant decrease of the retention factor (from about 80 per cent to 20 per cent).Comment: Accepted for publication in MNRAS, 17 pages, 11 figure

Magnetic Resonance Imaging of the Hips of Runners Before and After their First Marathon Run: Does it Lead to Acute Changes?

BACKGROUND: No studies have focused on magnetic resonance imaging (MRI) of the hips of marathoners, despite the popularity and injury risks of marathon running. PURPOSE: To understand the effect of preparing for and completing a marathon run (42 km) on runners’ hip joints by comparing MRI findings before and after their first marathon. Study Design: Case-control study; Level of evidence, 3. METHODS: A total of 28 healthy adults (14 males, 14 females; mean age, 32.4 years) were recruited after registering for their first marathon. They underwent 3-T MRI of both hips at 16 weeks before (time point 1) and 2 weeks after the marathon (time point 2). After the first MRI, 21 runners completed the standardized, 4 month--long training program and the marathon; 7 runners did not complete the training or the marathon. Specialist musculoskeletal radiologists reported and graded the hip joint structures using validated scoring systems. Participants completed the Hip disability and Osteoarthritis Outcome Score (HOOS) at both imaging time points. RESULTS: At time point 1, MRI abnormalities of the hip joint were seen in 90% of participants and were located in at least 1 of these areas: labrum (29%), articular cartilage (7%), subchondral bone marrow (14%), tendons (17%), ligaments (14%), and muscles (31% had moderate muscle atrophy). At time point 2, only 2 of the 42 hips showed new findings: a small area of mild bone marrow edema appearance (nonweightbearing area of the hip and not attributable to running). There was no significant difference in HOOS between the 2 time points. Only 1 participant did not finish the training because of hip symptoms and thus did not run the marathon; however, symptoms resolved before the MRI at time point 2. Six other participants discontinued their training because of non–hip related issues: a knee injury, skin disease, a family bereavement, Achilles tendon injury, illness unrelated to training, and a foot injury unrelated to training. CONCLUSION: Runners who completed a 4-month beginner training program before their first marathon run, plus the race itself, showed no hip damage on 3-T MRI scans

H2-based star formation laws in hierarchical models of galaxy formation

5We update our recently published model for GAlaxy Evolution and Assembly (GAEA), to include a self-consistent treatment of the partition of cold gas in atomic and molecular hydrogen. Our model provides significant improvements with respect to previous ones used for similar studies. In particular, GAEA (i) includes a sophisticated chemical enrichment scheme accounting for non-instantaneous recycling of gas, metals and energy; (ii) reproduces the measured evolution of the galaxy stellar mass function; (iii) reasonably reproduces the observed correlation between galaxy stellar mass and gas metallicity at different redshifts. These are important prerequisites for models considering a metallicity-dependent efficiency of molecular gas formation. We also update our model for disc sizes and show that model predictions are in nice agreement with observational estimates for the gas, stellar and star-forming discs at different cosmic epochs. We analyse the influence of different star formation laws including empirical relations based on the hydrostatic pressure of the disc, analytic models and prescriptions derived from detailed hydrodynamical simulations. We find that modifying the star formation law does not affect significantly the global properties of model galaxies, neither their distributions. The only quantity showing significant deviations in different models is the cosmic molecular-to-atomic hydrogen ratio, particularly at high redshift. Unfortunately, however, this quantity also depends strongly on the modelling adopted for additional physical processes. Useful constraints on the physical processes regulating star formation can be obtained focusing on low-mass galaxies and/or at higher redshift. In this case, self-regulation has not yet washed out differences imprinted at early time.openopenXie, Lizhi; De Lucia, Gabriella; Hirschmann, Michaela; Fontanot, Fabio; Zoldan, AnnaXie, Lizhi; De Lucia, Gabriella; Hirschmann, Michaela; Fontanot, Fabio; Zoldan, Ann

The carpometacarpal joint of the thumb: MR appearance in asymptomatic volunteers

Purpose: To prospectively characterize the MR appearance of the carpometacarpal (CMC) joint of the thumb in asymptomatic volunteers. Materials and methods: Thirty-four asymptomatic volunteers (17 women, 17 men, mean age, 33.9 ± 9.2years) underwent MR imaging of the thumb after approval by the local ethical committee. Two musculoskeletal radiologists independently classified visibility and signal intensity (SI) characteristics of the anterior oblique (AOL/beak ligament), the posterior oblique (POL), the intermetacarpal (IML), and the dorsoradial ligaments (DRL) on a three-point Likert scale. The thickness of all ligaments, cartilage integrity, and presence of joint fluid were assessed. The alignment of the first metacarpal base with the trapezium was quantified on sagittal and coronal planes. Results: The ligaments of the CMC joint were constantly visible in all volunteers for the POL and IML, and in all but one for the AOL and DRL. On intermediate-weighted fat-saturated images the POL (65%/74% reader 1/reader 2) and DRL (58%/64%) were commonly of increased SI, while the IML had a striated appearance in 91%/76% of subjects. The AOL showed a variable SI (36%/42% low, 27%/27% increased, 36%/30% striated). The IML was the thickest ligament with a mean of 2.9mm/3.1mm and the DRL the thinnest (1.2mm/1.4mm). There was a mean dorsal subluxation of 1.8mm/2.0mm and radial subluxation of 2.8mm/3.4mm of the metacarpal base. The AOL was significantly thicker in men (1.7mm) than in women (1.2mm; p = 0.02). Radial subluxation was significantly larger in men (3.4mm) than in women (2.2mm; p = 0.02). No subluxation in palmar or ulnar direction was seen. Conclusions: Radial and dorsal subluxation of the CMC joint can be a normal finding in a resting position at MR imaging. The CMC ligaments showed a considerable variability of signal intensity with a typically striated IML; thickness of the AOL is typically less than 2.2mm, of the POL typically less than 2.9m

4D-SPECT/CT in orthopaedics: a new method of combined quantitative volumetric 3D analysis of SPECT/CT tracer uptake and component position measurements in patients after total knee arthroplasty

Objective: The purpose was to evaluate the intra- and inter-observer reliability of combined quantitative 3D-volumetric single-photon emission computed tomography (SPECT)/CT analysis including size, intensity and localisation of tracer uptake regions and total knee arthroplasty (TKA) position. Materials and methods: Tc-99m-HDP-SPECT/CT of 100 knees after TKA were prospectively analysed. The anatomical areas represented by a previously validated localisation scheme were 3D-volumetrically analysed. The maximum intensity was recorded for each anatomical area. Ratios between the respective value and the mid-shaft of the femur as the reference were calculated. Femoral and tibial TKA position (varus-valgus, flexion-extension, internal rotation- external rotation) were determined on 3D-CT. Two consultant radiologists/nuclear medicine physicians interpreted the SPECT/CTs twice with a 2-week interval. The inter- and intra-observer reliability was determined (ICCs). Kappa values were calculated for the area with the highest tracer uptake between the observers. Results: The measurements of tracer uptake intensity showed excellent inter- and intra-observer reliabilities for all regions (tibia, femur and patella). Only the tibial shaft area showed ICCs 0.84). Conclusion: This combined 3D-volumetric standardised method of analysing the location, size and the intensity of SPECT/CT tracer uptake regions ("hotspots”) and the determination of the TKA position was highly reliable and represents a novel promising approach to biomechanic

Upright Cone CT of the hindfoot: Comparison of the non-weight-bearing with the upright weight-bearing position

Objectives: To prospectively compare computed tomography (CT) of the hindfoot in the supine non-weight-bearing position (NWBCT) with upright weight-bearing position (WBCT). Methods: Institutional review board approval and informed consent of all patients were obtained. NWBCT and WBCT scans of the ankle were obtained in 22 patients (mean age, 46.0 ± 17.1years; range 19-75years) using a conventional 64-row CT for NWBCT and a novel cone-beam CT for WBCT. Two musculoskeletal radiologists independently performed the following measurements: the hindfoot alignment angle, fibulocalcaneal and tibiocalcaneal distances, lateral talocalcaneal joint space width, talocalcaneal overlap and naviculocalcaneal distance. Significant changes between NWBCT and WBCT were sought using Wilcoxon signed-rank test. P values <0.05 were considered statistically significant. Results: Significant differences were found for all measurements except the hindfoot alignment angle and tibiocalcaneal distance. Significant measurement results were as follows (NWBCT/WBCT reader 1; NWBCT/WBCT reader 2, mean ± standard deviation): fibulocalcaneal distance 3.6mm ± 5.2/0.3mm ± 6.0 (P = 0.006); 1.4mm ± 6.3/-1.1mm ± 6.3 (P = 0.002), lateral talocalcaneal joint space width 2.9mm ± 1.7/2.2mm ± 1.1 (P = 0.005); 3.4mm ± 1.9/2.4mm ± 1.3 (P = 0.001), talocalcaneal overlap 4.1mm ± 3.9/1.4mm ± 3.9 (P = 0.001); 4.5mm ± 4.3/1.4mm ± 3.7 (P < 0.001) and naviculocalcaneal distance 13.5mm ± 4.0/15.3mm ± 4.7 (P = 0.037); 14.0mm ± 4.4/15.7mm ± 6.2 (P = 0.100). Interreader agreement was good to excellent (ICC 0.48-0.94). Conclusion: Alignment of the hindfoot significantly changes in the upright weight-bearing CT position. Differences can be visualised and measured using WBCT. Key Points : • Cone-beam computed tomography (CBCT) offers new opportunities for musculoskeletal problems • Visualization and quantification of hindfoot alignment are possible in upright weight-bearing CBCT • Hindfoot alignment changes significantly from non-weight-bearing to weight-bearing CT • The weight-bearing position leads to a decrease in the fibulocalcaneal distance and talocalcaneal overlap • The naviculocalcaneal distance is increased in the weight-bearing positio

The carpometacarpal joint of the thumb: MR appearance in asymptomatic volunteers

PURPOSE: To prospectively characterize the MR appearance of the carpometacarpal (CMC) joint of the thumb in asymptomatic volunteers. MATERIALS AND METHODS: Thirty-four asymptomatic volunteers (17 women, 17 men, mean age, 33.9 ± 9.2 years) underwent MR imaging of the thumb after approval by the local ethical committee. Two musculoskeletal radiologists independently classified visibility and signal intensity (SI) characteristics of the anterior oblique (AOL/beak ligament), the posterior oblique (POL), the intermetacarpal (IML), and the dorsoradial ligaments (DRL) on a three-point Likert scale. The thickness of all ligaments, cartilage integrity, and presence of joint fluid were assessed. The alignment of the first metacarpal base with the trapezium was quantified on sagittal and coronal planes. RESULTS: The ligaments of the CMC joint were constantly visible in all volunteers for the POL and IML, and in all but one for the AOL and DRL. On intermediate-weighted fat-saturated images the POL (65 %/74 % reader 1/reader 2) and DRL (58 %/64 %) were commonly of increased SI, while the IML had a striated appearance in 91 %/76 % of subjects. The AOL showed a variable SI (36 %/42 % low, 27 %/27 % increased, 36 %/30 % striated). The IML was the thickest ligament with a mean of 2.9 mm/3.1 mm and the DRL the thinnest (1.2 mm/1.4 mm). There was a mean dorsal subluxation of 1.8 mm/2.0 mm and radial subluxation of 2.8 mm/3.4 mm of the metacarpal base. The AOL was significantly thicker in men (1.7 mm) than in women (1.2 mm; p = 0.02). Radial subluxation was significantly larger in men (3.4 mm) than in women (2.2 mm; p = 0.02). No subluxation in palmar or ulnar direction was seen. CONCLUSIONS: Radial and dorsal subluxation of the CMC joint can be a normal finding in a resting position at MR imaging. The CMC ligaments showed a considerable variability of signal intensity with a typically striated IML; thickness of the AOL is typically less than 2.2 mm, of the POL typically less than 2.9 mm

Upright Cone CT of the hindfoot: Comparison of the non-weight-bearing with the upright weight-bearing position

OBJECTIVES: To prospectively compare computed tomography (CT) of the hindfoot in the supine non-weight-bearing position (NWBCT) with upright weight-bearing position (WBCT). METHODS: Institutional review board approval and informed consent of all patients were obtained. NWBCT and WBCT scans of the ankle were obtained in 22 patients (mean age, 46.0 ± 17.1 years; range 19-75 years) using a conventional 64-row CT for NWBCT and a novel cone-beam CT for WBCT. Two musculoskeletal radiologists independently performed the following measurements: the hindfoot alignment angle, fibulocalcaneal and tibiocalcaneal distances, lateral talocalcaneal joint space width, talocalcaneal overlap and naviculocalcaneal distance. Significant changes between NWBCT and WBCT were sought using Wilcoxon signed-rank test. P values <0.05 were considered statistically significant. RESULTS: Significant differences were found for all measurements except the hindfoot alignment angle and tibiocalcaneal distance. Significant measurement results were as follows (NWBCT/WBCT reader 1; NWBCT/WBCT reader 2, mean ± standard deviation): fibulocalcaneal distance 3.6 mm ± 5.2/0.3 mm ± 6.0 (P = 0.006); 1.4 mm ± 6.3/-1.1 mm ± 6.3 (P = 0.002), lateral talocalcaneal joint space width 2.9 mm ± 1.7/2.2 mm ± 1.1 (P = 0.005); 3.4 mm ± 1.9/2.4 mm ± 1.3 (P = 0.001), talocalcaneal overlap 4.1 mm ± 3.9/1.4 mm ± 3.9 (P = 0.001); 4.5 mm ± 4.3/1.4 mm ± 3.7 (P < 0.001) and naviculocalcaneal distance 13.5 mm ± 4.0/15.3 mm ± 4.7 (P = 0.037); 14.0 mm ± 4.4/15.7 mm ± 6.2 (P = 0.100). Interreader agreement was good to excellent (ICC 0.48-0.94). CONCLUSION: Alignment of the hindfoot significantly changes in the upright weight-bearing CT position. Differences can be visualised and measured using WBCT. KEY POINTS: • Cone-beam computed tomography (CBCT) offers new opportunities for musculoskeletal problems • Visualization and quantification of hindfoot alignment are possible in upright weight-bearing CBCT • Hindfoot alignment changes significantly from non-weight-bearing to weight-bearing CT • The weight-bearing position leads to a decrease in the fibulocalcaneal distance and talocalcaneal overlap • The naviculocalcaneal distance is increased in the weight-bearing position

Clinical value of SPECT/CT for evaluation of patients with painful knees after total knee arthroplasty- a new dimension of diagnostics?

<p>Abstract</p> <p>Background</p> <p>The purpose of our study was to evaluate the clinical value of hybrid SPECT/CT for the assessment of patients with painful total knee arthroplasty (TKA).</p> <p>Methods</p> <p>Twenty-three painful knees in patients following primary TKA were assessed using Tc-99m-HDP-SPECT/CT. Rotational, sagittal and coronal position of the TKA was assessed on 3D-CT reconstructions. The level of the SPECT-tracer uptake (0-10) and its anatomical distribution was mapped using a validated localization scheme. Univariate analysis (Wilcoxon-Mann-Whitney, Spearmean`s-rho test, p < 0.05) was performed to identify any correlations between component position, tracer uptake and diagnosis.</p> <p>Results</p> <p>SPECT/CT imaging changed the suspected diagnosis and the proposed treatment in 19/23 (83%) knees. Progression of patellofemoral OA (n = 11), loosening of the tibial (n = 3) and loosening of the femoral component (n = 2) were identified as the leading causes of pain after TKA.</p> <p>Patients with externally rotated tibial trays showed higher tracer uptake in the medial patellar facet (p = 0.049) and in the femur (p = 0.051). Patients with knee pain due to patellofemoral OA showed significantly higher tracer uptake in the patella than others (p < 0.001).</p> <p>Conclusions</p> <p>SPECT/CT was very helpful in establishing the diagnosis and guiding subsequent management in patients with painful knees after TKA, particularly in patients with patellofemoral problems and malpositioned or loose TKA.</p