Attenuated and Nonproductive Viral Transcription in the Lymphatic Tissue of HIV-1-Infected Patients Receiving Potent Antiretroviral Therapy

Human immunodeficiency virus type 1 (HIV-1) RNA that persists in the lymphoid tissue of patients despite treatment with highly active antiretroviral therapy (HAART) may represent extracellular virions or intracellular RNAs residing within HIV-infected cells. To further characterize residual viral transcription, tonsil biopsy specimens from patients receiving long-term HAART, untreated patients, and patients undergoing 2 weeks of structured treatment interruption were analyzed by polymerase chain reaction quantification of virion-encapsidated RNA, intracellular unspliced HIV RNA (HIV UsRNA), multiply spliced HIV RNA encoding tat and rev (HIV MsRNA), and HIV DNA. Tonsil biopsy specimens from viremic patients harbored high amounts of virions, which primarily stemmed from local production, as indicated by a strong correlation of extracellular tonsillar RNA with intracellular HIV-1 nucleic acid levels but not with plasma viremia, and as shown by phylogenetic analysis of clonal env sequences from lymphoid tissue and plasma. In patients receiving HAART, intracellular HIV UsRNA persisted at significantly decreased levels, whereas HIV MsRNA and lymphoid virion levels were depleted. Thus, residual lymphoid HIV-1 RNA in patients receiving HAART indicates attenuated viral transcription in HIV-1-infected cells that lack virion productio

Morbidity and Aging in HIV-Infected Persons: The Swiss HIV Cohort Study

Comorbid diseases, such as myocardial infarction, stroke, diabetes mellitus, bone fractures without adequate trauma, osteoporosis, and non-AIDS-defining malignancies, among HIV-infected individuals are age-related. Consequently, multimorbidity will become an important issue in care of the aging HIV-infected populatio

Geschichte der Medicin, in den Grundzügen ihrer Entwicklung dargestellt

von Bernhard Hirsche

Tagebuch eines Gefangenen : (1849).

Transcript of Hirschel's diary describing his time in prison after his involvement in the 1848/1849 revolutionary events in Dresden.The physician Bernhard Baruch Hirschel was born in Dresden in 1815. He attended the Christian "Kreuzschule" and studied medicine at Leipzig University. Hirschel died in 1874.Brief summary in Max Kreutzberger: "Leo Baeck Institute New York, Bibliothek und Archiv; Katalog": C 185Published in Monika Richarz: "Juedisches Leben in Deutschland": Vol. I 39Education; JewishEducation; primary and secondary; before 1871Education, Highe

Der homöopathische Arzneischatz in seiner Anwendung am Krankenbette. Für Familie und Haus.

3...verb. und verm. aufl.Mode of access: Internet

Compendium der Homoeopathie nach ihrem neuesten Standpunkte ...

Mode of access: Internet

Meine Lebensgeschichte : für meine Kinder niedergeschrieben.

Transcript of Bernhard Hirschel's memoir: Account of primary and secondary education in Dresden; university studies in Leipzig; social rise from poor family to well-known physician.Also included are a recommendation by the director of the "Kreuzschule" and Hirschel's obituary.The physician Bernhard Baruch Hirschel was born in Dresden in 1815. He attended the Christian "Kreuzschule" and studied medicine at Leipzig University. Hirschel died in 1874.Brief summary in Max Kreutzberger: "Leo Baeck Institute New York, Bibliothek und Archiv; Katalog": C 185Published in Monika Richarz: "Juedisches Leben in Deutschland": Vol. I 39Education; Jewis

Zum hundertjährigen geburtstage Samuel Hahnemann's. Reden und crinnerungsblätter an die feier des 11. April 1855 in Meissen, hrsg.

Mode of access: Internet

Guide du médecin homoeopathe ...

Mode of access: Internet

Der homöopathische Arzneischatz in seiner Anwendung am Krankenbette...

p. [289]-300, advertising matter.Mode of access: Internet