Increasing static noise margin of single-bit-line SRAM by lowering bit-line voltage during reading

A 64-kb SRAM circuit with a single bit line (BL) for reading and with two BLs for writing was designed. Single-BL reading is achieved by using a left access transistor and a left shared reading port. We designed the cell layout and confirmed that there is no area penalty for producing two word lines in a memory cell. An analysis of butterfly plots clearly confirms that the single-BL SRAM has the larger static noise margin than the two-BL one. It is confirmed that the static noise margin in the single-BL SRAM is further increased when the BL is precharged to not VDD but to the lower value in the range of VDD/2 to 3VDD/4. In addition, a new sense amplifier circuit without reference voltage is proposed for single-BL reading. We also propose a divided word line architecture for writing to maintain the static noise margin for unwritten blocks. © 2011 IEEE

Accelerated evaluation method for the SRAM cell write margin using word line voltage shift

An accelerated evaluation method for the SRAM cell write margin is proposed based on the conventional Write Noise Margin (WNM) definition. The WNM is measured under a lower word line voltage than the power supply voltage VDD. A lower word line voltage is used because the access transistor operates in the saturation mode over a wide range of threshold voltage variation. The final WNM at the VDD word line voltage, the Accelerated Write Noise Margin (AWNM), is obtained by shifting the measured WNM at the lower word line voltage. The amount of WNM shift is determined from the WNM dependence on the word line voltage. As a result, the cumulative frequency of the AWNM displays a normal distribution. A normal distribution of the AWNM drastically improves development efficiency, because the write failure probability can be estimated by a small number of samples. Effectiveness of the proposed method is verified using the Monte Carlo simulation. © 2011 IEEE

Mast Cell Infiltration is Associated with Myelofibrosis and Angiogenesis in Myelodysplastic Syndromes

Myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by persistent peripheral cytopenia with morphological and functional abnormalities of hematopoietic cells. Mast cells infiltrate into or around tumor tissues and play a role in remodeling of the stromal microenvironment, contributing to tumor progression. Increased mast cell numbers are associated with fibrosis, angiogenesis and a poor prognosis in human carcinomas. The aim of this study was to determine whether mast cell infiltration contributes to myelofibrosis or angiogenesis in myelodysplastic syndromes. We evaluated the correlation between mast cell density and the extent of myelofibrosis and angiogenesis in myelodysplastic syndromes. Fifty bone marrow biopsies taken from patients with a diagnosis of myelodysplastic syndromes were examined. Grading of myelofibrosis was evaluated by silver impregnation staining. Mast cell density and microvessel density were evaluated by immunohistochemistry. Human mast cells have been divided into two phenotypes. We designated a tryptase-positive mast cell as MCT and a chymase-positive mast cell as MCTC. Microvessels were identified by CD34-positive endothelial cells. Microvessel density and the extent of myelofibrosis were significantly greater in patients with high MCT and MCTC density compared to those with low MC density. Based on this, we suggest that the presence of high mast cell numbers is associated with myelofibrosis and angiogenesis in myelodysplastic syndromes

The Plasma Wave Experiment (PWE) on board the Arase (ERG) satellite

The Exploration of energization and Radiation in Geospace (ERG) project aims to study acceleration and loss mechanisms of relativistic electrons around the Earth. The Arase (ERG) satellite was launched on December 20, 2016, to explore in the heart of the Earth’s radiation belt. In the present paper, we introduce the specifications of the Plasma Wave Experiment (PWE) on board the Arase satellite. In the inner magnetosphere, plasma waves, such as the whistler-mode chorus, electromagnetic ion cyclotron wave, and magnetosonic wave, are expected to interact with particles over a wide energy range and contribute to high-energy particle loss and/or acceleration processes. Thermal plasma density is another key parameter because it controls the dispersion relation of plasma waves, which affects wave–particle interaction conditions and wave propagation characteristics. The DC electric field also plays an important role in controlling the global dynamics of the inner magnetosphere. The PWE, which consists of an orthogonal electric field sensor (WPT; wire probe antenna), a triaxial magnetic sensor (MSC; magnetic search coil), and receivers named electric field detector (EFD), waveform capture and onboard frequency analyzer (WFC/OFA), and high-frequency analyzer (HFA), was developed to measure the DC electric field and plasma waves in the inner magnetosphere. Using these sensors and receivers, the PWE covers a wide frequency range from DC to 10 MHz for electric fields and from a few Hz to 100 kHz for magnetic fields. We produce continuous ELF/VLF/HF range wave spectra and ELF range waveforms for 24 h each day. We also produce spectral matrices as continuous data for wave direction finding. In addition, we intermittently produce two types of waveform burst data, “chorus burst” and “EMIC burst.” We also input raw waveform data into the software-type wave–particle interaction analyzer (S-WPIA), which derives direct correlation between waves and particles. Finally, we introduce our PWE observation strategy and provide some initial results

The Japanese Clinical Practice Guideline for acute kidney injury 2016

Acute kidney injury (AKI) is a syndrome which has a broad range of etiologic factors depending on different clinical settings. Because AKI has significant impacts on prognosis in any clinical settings, early detection and intervention are necessary to improve the outcomes of AKI patients. This clinical guideline for AKI was developed by a multidisciplinary approach with nephrology, intensive care medicine, blood purification, and pediatrics. Of note, clinical practice for AKI management which was widely performed in Japan was also evaluated with comprehensive literature search

Brightened single-bubble sonoluminescence by phase-adjusted high-frequency acoustic pulse

This paper experimentally and numerically studies the effect of a high-frequency acoustic pulse on brightening single-bubble sonoluminescence (SBSL). A polyvinylidene fluoride point-focusing transducer was driven by a 700-W pulse generator to superimpose the acoustic pulse on the sonoluminescing bubble. The center frequency of the pulse was 10 MHz and the duration was 0.15 μs. The pulse was triggered every 100 cycles of the low-frequency standing wave used to make SBSL. The intensity of SBSL was measured as a function of time lag of superimposed pulse. Only the pulse that arrived at the bubble at the early growing stage could increase the brightness. This trend was confirmed with a numerical calculation based on the Rayleigh-Plesset equation. The increased brightness reached 300% of those of the classical SBSL flashes when the time lag was correctly adjusted. © 2003 The American Physical Society.Ogi H., Matsuda A., Wada K., et al. "Brightened single-bubble sonoluminescence by phase-adjusted high-frequency acoustic pulse", Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics, 67(5), 056301, 2003 https://doi.org/10.1103/PhysRevE.67.056301

Acoustic properties of co-doped AlN thin films at low temperatures studied by picosecond ultrasonics

Nagakubo A., Arita M., Yokoyama T., et al. "Acoustic properties of co-doped AlN thin films at low temperatures studied by picosecond ultrasonics", Japanese Journal of Applied Physics, 54(7), 07HD01 (2015) https://doi.org/10.7567/JJAP.54.07HD01

Effect of temporal fluctuation of selection coefficient on gene frequency in a population

The diffusion equations describing the change of gene frequencies are extended to include the effect of temporal fluctuation of selection coefficient that may persist for some generations. The equilibrium distribution of gene frequencies and the fixation probability of a mutant gene are obtained from the extended equations. Comparison is made with the experimental data on protein polymorphism. A possible bearing of the fluctuation of selection coefficient on the problem of molecular evolution is discussed in relation to the neutral theory