Time Course of Recruitment, Pit Formation and Apoptosis of Osteoclast Populations on Dentin In Vitro

The resorptive capacity of osteoclasts in vitro has been used as an indicator of bone resorption. However, the kinetics of osteoclast development and senescence is not well understood. It has been noted that mononuclear precursors migrate to calcified substrate and after multi-nucleation become competent bone resorbing cells. Osteoclasts, once finished a wave of resorption, become senescent. In order to determine the survival characteristics of osteoclast populations involved in calcified tissue destruction, we have investigated the time course of the recruitment to dentin and apoptosis of osteoclasts. We have established the linkage between these measurements and the time course of the appearance of pits using both chick and rat osteoclasts in vitro. Osteoclasts from both species caused increases in pit number associated with decreases in cell number on dentin. In the rat model, we have used a fluorescent linker to mark cells before they migrate to dentin and have shown that cells can be followed from the culture dish onto the dentin disc. In the chick model, we have used time lapse cinematography and fluorescent nuclear staining to observe death of osteoclasts on dentin and have established an osteoclast half live in vitro

The dependency pair framework: Combining techniques for automated termination proofs

Abstract. The dependency pair approach is one of the most powerful techniques for automated termination proofs of term rewrite systems. Up to now, it was regarded as one of several possible methods to prove termination. In this paper, we show that dependency pairs can instead be used as a general concept to integrate arbitrary techniques for termination analysis. In this way, the benefits of different techniques can be combined and their modularity and power are increased significantly. We refer to this new concept as the “dependency pair framework ” to distinguish it from the old “dependency pair approach”. Moreover, this framework facilitates the development of new methods for termination analysis. To demonstrate this, we present several new techniques within the dependency pair framework which simplify termination problems considerably. We implemented the dependency pair framework in our termination prover AProVE and evaluated it on large collections of examples.

On the absence of eigenvectors of Hamiltonians in a class of massless quantum field models without infrared cutoff

AbstractA class of models of quantized, massless Bose fields, called the generalized spin-boson model (A. Arai and M. Hirokawa, J. Funct. Anal.151 (1997), 455–503) is considered. Theorems on the absence of ground states and the other eigenvectors of the model without infrared cutoff (but with ultraviolet cutoff) are established with conditions in terms of correlation functions for some operators

Field evolution of the magnetic structures in Er2_2Ti2_2O7_7 through the critical point

We have measured neutron diffraction patterns in a single crystal sample of the pyrochlore compound Er$_2$Ti$_2$O$_7$ in the antiferromagnetic phase (T=0.3\,K), as a function of the magnetic field, up to 6\,T, applied along the [110] direction. We determine all the characteristics of the magnetic structure throughout the quantum critical point at $H_c$=2\,T. As a main result, all Er moments align along the field at $H_c$ and their values reach a minimum. Using a four-sublattice self-consistent calculation, we show that the evolution of the magnetic structure and the value of the critical field are rather well reproduced using the same anisotropic exchange tensor as that accounting for the local paramagnetic susceptibility. In contrast, an isotropic exchange tensor does not match the moment variations through the critical point. The model also accounts semi-quantitatively for other experimental data previously measured, such as the field dependence of the heat capacity, energy of the dispersionless inelastic modes and transition temperature.Comment: 7 pages; 8 figure

Absence of Ground States for a Class of Translation Invariant Models of Non-relativistic QED

We consider a class of translation invariant models of non-relativistic QED with net charge. Under certain natural assumptions we prove that ground states do not exist in the Fock space

Dicke-Type Energy Level Crossings in Cavity-Induced Atom Cooling: Another Superradiant Cooling

This paper is devoted to energy-spectral analysis for the system of a two-level atom coupled with photons in a cavity. It is shown that the Dicke-type energy level crossings take place when the atom-cavity interaction of the system undergoes changes between the weak coupling regime and the strong one. Using the phenomenon of the crossings we develop the idea of cavity-induced atom cooling proposed by the group of Ritsch, and we lay mathematical foundations of a possible mechanism for another superradiant cooling in addition to that proposed by Domokos and Ritsch. The process of our superradiant cooling can function well by cavity decay and by control of the position of the atom, at least in (mathematical) theory, even if there is neither atomic absorption nor atomic emission of photons.Comment: 15 pages; 8 figure

Reducing relative termination to dependency pair problems

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-21401-6_11Relative termination, a generalized notion of termination, has been used in a number of different contexts like proving the confluence of rewrite systems or analyzing the termination of narrowing. In this paper, we introduce a new technique to prove relative termination by reducing it to dependency pair problems. To the best of our knowledge, this is the first significant contribution to Problem #106 of the RTA List of Open Problems. The practical significance of our method is illustrated by means of an experimental evaluation.Germán Vidal is partially supported by the EU (FEDER) and the Spanish Ministerio de Economía y Competitividad under grant TIN2013-44742-C4-R and by the Generalitat Valenciana under grant PROMETEOII201/013. Akihisa Yamadais supported by the Austrian Science Fund (FWF): Y757Iborra, J.; Nishida, N.; Vidal Oriola, GF.; Yamada, A. (2015). Reducing relative termination to dependency pair problems. En Automated Deduction - CADE-25. Springer. 163-178. https://doi.org/10.1007/978-3-319-21401-6_11S163178Alarcón, B., Lucas, S., Meseguer, J.: A dependency pair framework for A $$\vee$$ C-termination. In: Ölveczky, P.C. (ed.) WRLA 2010. LNCS, vol. 6381, pp. 35–51. Springer, Heidelberg (2010)Arts, T., Giesl, J.: Termination of term rewriting using dependency pairs. Theor. Comput. Sci. 236(1–2), 133–178 (2000)Arts, T., Giesl, J.: A collection of examples for termination of term rewriting using dependency pairs. Technical report AIB-2001-09, RWTH Aachen (2001)Baader, F., Nipkow, T.: Term Rewriting and All That. Cambridge University Press, Cambridge (1998)Dershowitz, N.: Termination of rewriting. J. Symb. Comput. 3(1&2), 69–115 (1987)Endrullis, J., Waldmann, J., Zantema, H.: Matrix interpretations for proving termination of term rewriting. J. Autom. Reasoning 40(2–3), 195–220 (2008)Geser, A.: Relative termination. Dissertation, Fakultät für Mathematik und Informatik, Universität Passau, Germany (1990)Giesl, J., Kapur, D.: Dependency pairs for equational rewriting. In: Middeldorp, A. (ed.) RTA 2001. LNCS, vol. 2051, pp. 93–107. Springer, Heidelberg (2001)Giesl, J., Schneider-Kamp, P., Thiemann, R.: AProVE 1.2: automatic termination proofs in the dependency pair framework. In: Furbach, U., Shankar, N. (eds.) IJCAR 2006. LNCS (LNAI), vol. 4130, pp. 281–286. Springer, Heidelberg (2006)Giesl, J., Thiemann, R., Schneider-Kamp, P., Falke, S.: Mechanizing and improving dependency pairs. J. Autom. Reasoning 37(3), 155–203 (2006)Hirokawa, N., Middeldorp, A.: Polynomial interpretations with negative coefficients. In: Buchberger, B., Campbell, J. (eds.) AISC 2004. LNCS (LNAI), vol. 3249, pp. 185–198. Springer, Heidelberg (2004)Hirokawa, N., Middeldorp, A.: Dependency pairs revisited. In: van Oostrom, V. (ed.) RTA 2004. LNCS, vol. 3091, pp. 249–268. Springer, Heidelberg (2004)Hirokawa, N., Middeldorp, A.: Decreasing diagrams and relative termination. J. Autom. Reasoning 47(4), 481–501 (2011)Hullot, J.M.: Canonical forms and unification. CADE-5. LNCS, vol. 87, pp. 318–334. Springer, Heidelberg (1980)Iborra, J., Nishida, N., Vidal, G.: Goal-directed and relative dependency pairs for proving the termination of narrowing. In: De Schreye, D. (ed.) LOPSTR 2009. LNCS, vol. 6037, pp. 52–66. Springer, Heidelberg (2010)Kamin, S., Lévy, J.J.: Two generalizations of the recursive path ordering (1980, unpublished note)Klop, J.W.: Term rewriting systems: a tutorial. Bull. Eur. Assoc. Theor. Comput. Sci. 32, 143–183 (1987)Koprowski, A., Zantema, H.: Proving liveness with fairness using rewriting. In: Gramlich, B. (ed.) FroCos 2005. LNCS (LNAI), vol. 3717, pp. 232–247. Springer, Heidelberg (2005)Koprowski, A.: TPA: termination proved automatically. In: Pfenning, F. (ed.) RTA 2006. LNCS, vol. 4098, pp. 257–266. Springer, Heidelberg (2006)Korp, M., Sternagel, C., Zankl, H., Middeldorp, A.: Tyrolean termination tool 2. In: Treinen, R. (ed.) RTA 2009. LNCS, vol. 5595, pp. 295–304. Springer, Heidelberg (2009)Lankford, D.: Canonical algebraic simplification in computational logic. Technical report ATP-25, University of Texas (1975)Liu, J., Dershowitz, N., Jouannaud, J.-P.: Confluence by critical pair analysis. In: Dowek, G. (ed.) RTA-TLCA 2014. LNCS, vol. 8560, pp. 287–302. Springer, Heidelberg (2014)Nishida, N., Sakai, M., Sakabe, T.: Narrowing-based simulation of term rewriting systems with extra variables. ENTCS 86(3), 52–69 (2003)Nishida, N., Vidal, G.: Termination of narrowing via termination of rewriting. Appl. Algebra Eng. Commun. Comput. 21(3), 177–225 (2010)Ohlebusch, E.: Advanced Topics in Term Rewriting. Springer-Verlag, London (2002)Thiemann, R., Allais, G., Nagele, J.: On the formalization of termination techniques based on multiset orderings. In: RTA 2012. LIPIcs, vol. 15, pp. 339–354. Schloss Dagstuhl - Leibniz-Zentrum für Informatik (2012)Vidal, G.: Termination of narrowing in left-linear constructor systems. In: Garrigue, J., Hermenegildo, M.V. (eds.) FLOPS 2008. LNCS, vol. 4989, pp. 113–129. Springer, Heidelberg (2008)Yamada, A., Kusakari, K., Sakabe, T.: Nagoya termination tool. In: Dowek, G. (ed.) RTA-TLCA 2014. LNCS, vol. 8560, pp. 466–475. Springer, Heidelberg (2014)Yamada, A., Kusakari, K., Sakabe, T.: A unified ordering for termination proving. Sci. Comput. Program. (2014). doi: 10.1016/j.scico.2014.07.009Zantema, H.: Termination of term rewriting by semantic labelling. Fundamenta Informaticae 24(1/2), 89–105 (1995)Zantema, H.: Termination. In: Bezem, M., Klop, J.W., de Vrijer, R. (eds.) Term Rewriting Systems. Cambridge Tracts in Theoretical Computer Science, vol. 55, pp. 181–259. Cambridge University Press, Cambridge (2003

Ground State and Resonances in the Standard Model of Non-relativistic QED

We prove existence of a ground state and resonances in the standard model of the non-relativistic quantum electro-dynamics (QED). To this end we introduce a new canonical transformation of QED Hamiltonians and use the spectral renormalization group technique with a new choice of Banach spaces.Comment: 50 pages change

Analysis of multiple compound–protein interactions reveals novel bioactive molecules

The authors use machine learning of compound-protein interactions to explore drug polypharmacology and to efficiently identify bioactive ligands, including novel scaffold-hopping compounds for two pharmaceutically important protein families: G-protein coupled receptors and protein kinases

Elongation and fluctuations of semi-flexible polymers in a nematic solvent

We directly visualize single polymers with persistence lengths ranging from $\ell_p=0.05$ to 16 $\mu$m, dissolved in the nematic phase of rod-like {\it fd} virus. Polymers with sufficiently large persistence length undergo a coil-rod transition at the isotropic-nematic transition of the background solvent. We quantitatively analyze the transverse fluctuations of semi-flexible polymers and show that at long wavelengths they are driven by the fluctuating nematic background. We extract both the Odijk deflection length and the elastic constant of the background nematic phase from the data.Comment: 4 pages, 4 figures, submitted to PR