Seasonal and socio-demographic predictors of suicide in Ireland: A 22 year study

Background: Seasonal influences on suicide have been studied for many years with inconclusive and contradictory findings. Methods: Data on suicide in Ireland from 1980 to 2002 was examined to ascertain the contribution of season and demographic variables to suicide. Using Poisson regression modelling and sinusoidal analysis a small seasonal effect (7% from peak to trough) was identified but age, gender, marital status and residence were much larger contributors. The seasonal contribution increased in the latter half of the period under study. There was also a small seasonal effect for method of suicide. The suicide rate was highest in the 40–44 age group after controlling for confounders. Limitations:Because this was an ecological study, information on other possible contributors, such as mental illness was not available. Conclusions: These findings are discussed in light of international studies. Continuing studies are required to confirm the trend in increasing seasonality in Ireland. Since suicide is highest in those who are middle aged, preventive strategies should be directed to this group.Author has checked copyrigh

Emergency department management and outcome for self-poisoning: a cohort study

Self-poisoning in adults is an important public health problem across the world, but evidence to guide psychological management is lacking. In the current cohort study we wished to investigate whether aspects of routine Emergency Department management such as receiving a psycho-social assessment, or being referred for specialist follow up, affected the rate of repetition of self-poisoning. The study was carried out in four inner city hospitals in Greater Manchester, United Kingdom, over a 5-month period. We used hospital information systems and reviewed the case notes of every patient presenting to the Emergency Department to identify prospectively all adult patients presenting with deliberate self-poisoning. Data regarding the Emergency Department management of each episode were collected. The Manchester and Salford self-harm database was used to determine the number of individuals who went on to repeat self-poisoning within 6 months of their index episode. During the recruitment period 658 individuals presented with self-poisoning. Traditional risk factors for repetition such as substance dependence, psychiatric contact, and previous self-poisoning were associated with a greater likelihood of receiving a psycho-social assessment or being referred for specialist follow-up. Ninety-six patients (14.6%) repeated self-poisoning within 6 months of their index episode. After adjustment for baseline demographic and clinical characteristics and hospital, receiving a psycho-social assessment was not associated with reduced repetition but being referred for specialist follow-up was [adjusted hazard ratio for repetition (95% CI): 0.49 (0.25 to 0.84), P=.01]. We found that being referred for active follow-up after self-poisoning was associated with a reduced risk of repetition. The implications of this finding are discussed. Further studies using both cohort and randomized controlled study designs will help inform management strategies for patients who poison themselves

Deaths from natural causes in people with mental illness: A cohort study

Objectives: To investigate natural-cause mortality risk in people with psychiatric admission histories in a national population-based cohort. To estimate risks in relation to psychiatric diagnostic categories and for specific causes of death. Methods: We studied a 21-year cohort (1973-93) of 4.1 million Danish adults with linkage to national psychiatric and mortality registers. Person years were stratified by psychiatric diagnostic category and age-standardized mortality ratios (SMRs) were estimated versus the general population. Results: Risks of death by natural causes were higher across a range of psychiatric illnesses in both sexes. We observed SMRs greater than 200 in men and women with alcoholism, drug abuse, organic psychoses, dementia, and learning difficulties. Alcoholism and drug misuse in particular were important causes of premature mortality. The highest cause-specific SMRs were for nervous system diseases, gastrointestinal diseases, lung diseases, and "all other natural causes"; the lowest were for neoplasm. The greatest excess, in terms of absolute numbers, was for circulatory disease mortality. Conclusion: Adults experiencing a range of psychiatric illnesses are more likely to die at any age, and also prematurely, from natural causes. The consistency of elevated risk across psychiatric diagnoses and causes of death indicates an important health inequality. Those involved in planning and providing mental health services should address the heightened need for physical health care in psychiatric patients. © 2008 Elsevier Inc. All rights reserved

The incidence and associated risk factors for sudden unexplained death in psychiatric in-patients in England and Wales

Clinical characteristics and risk factors associated with sudden unexplained death (SUD) in the psychiatric population are unclear. Psychiatric in-patients (England, Wales) who met criteria for SUD were identified (1 March 1999-31 December 2005). Cases were matched with controls (in-patients alive on the day a SUD occurred). Data were collected via questionnaires. Some 283 cases of SUD were identified (41 annually), with a rate of 2.33/10,000 mental health admissions (in England). Electrocardiograms were not routine, cardiopulmonary resuscitation equipment was sometimes unavailable, attempts to resuscitate patients were carried out on one-half of all patients and post mortems/inquiries were not routine. Restraint and seclusion were uncommon. Risk factors included: benzodiazepines (odds ratio (OR): 1.83); ≥2 antipsychotics (OR: 2.35); promazine (OR: 4.02); diazepam (OR: 1.71); clozapine (OR: 2.10); cardiovascular disease (OR: 2.00); respiratory disease (OR: 1.98); diagnosis of dementia (OR: 2.08). Venlafaxine and a diagnosis of affective disorder were associated with reduced ORs (OR: 0.42; OR: 0.65). SUD is relatively rare, although it is more common in older patients and males. Prevention measures may include safer prescribing of antipsychotics and improved physical health care. The contribution of restraint or seclusion to SUD in individual cases is unclear. A uniform definition of SUD may help to identify contributing factors