70 research outputs found
Novel androgen-induced activity of an antimicrobial b-defensin: Regulation of Wolffian duct morphogenesis
Deep residual networks for quantification of muscle fiber orientation and curvature from ultrasound images
This paper concerns fully automatic and objective measurement of human skeletal muscle fiber orientation directly from standard b-mode ultrasound images using deep residual (ResNet) and convolutional neural networks (CNN). Fiber orientation and length is related with active and passive states of force production within muscle. There is currently no non-invasive way to measure force directly from muscle. Measurement of forces and other contractile parameters like muscle length change, thickness, and tendon length is not only important for understanding healthy muscle, but such information has contributed to understanding, diagnosis, monitoring, targeting and treatment of diseases ranging from myositis to stroke and motor neurone disease (MND). We applied well established deep learning methods to ultrasound data recorded from 19 healthy participants (5 female, ages: 30 ± 7.7) and achieved state of the art accuracy in predicting fiber orientation directly from ultrasound images of the calf muscles. First we used a previously developed segmentation technique to extract a region of interest within the gastrocnemius muscle. Then we asked an expert to annotate the main line of fiber orientation in 4 × 4 partitions of 400 normalized images. A linear model was then applied to the annotations to regulate and recover the orientation field for each image. Then we applied a CNN and a ResNet to predict the fiber orientation in each image. With leave one participant out cross-validation and dropout as a regulariser, we were able to demonstrate state of the art performance, recovering the fiber orientation with an average error of just 2°
The Role of Fibroblast Growth Factor Receptor Substrate 2 (FRS2) in the Regulation of Two Activity Levels of the Components of the Extracellular Signal-Regulated Kinase (ERK) Pathway in the Mouse Epididymis1
Male contraception: views to the 21st century, Bethesda, MD, USA, 9-10 September 1999
For men who still wish to father children, the contraceptive options
currently available are withdrawal and the condom. Although significant
progress has been made on hormonal and vaccine-related approaches to male
contraception, a marketed product is, at best, several years away.
Therefore, the National Institute of Child Health and Human Development
convened a workshop to discuss novel strategies for development of male
contraceptives that focused on the testis and epididymis. Participants
recognized that exploration of these new approaches will necessitate
considerable investment of funds and research efforts
The Blood-Testis and Blood-Epididymis Barriers Are More than Just Their Tight Junctions1
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