B mu G@Sbase - a microarray database and analysis tool

The manufacture and use of a whole-genome microarray is a complex process and it is essential that all data surrounding the process is stored, is accessible and can be easily associated with the data generated following hybridization and scanning. As part of a program funded by the Wellcome Trust, the Bacterial Microarray Group at St. George's Hospital Medical School (BμG@S) will generate whole-genome microarrays for 12 bacterial pathogens for use in collaboration with specialist research groups. BμG@S will collaborate with these groups at all levels, including the experimental design, methodology and analysis. In addition, we will provide informatic support in the form of a database system (BμG@Sbase). BμG@Sbase will provide access through a web interface to the microarray design data and will allow individual users to store their data in a searchable, secure manner. Tools developed by BμG@S in collaboration with specific research groups investigating analysis methodology will also be made available to those groups using the arrays and submitting data to BμG@Sbase

Problem-Solving Negotiation: Northern Ireland\u27s Experience with the Women\u27s Coalition Symposium

This paper is part of a Symposium that considered the relevance of domestic conflict resolution theories in broader cultural contexts. The Northern Ireland Women\u27s Coalition (Women\u27s Coalition) participated in the negotiations leading up to the 1998 Good Friday/Belfast Agreement. Members of the Woman\u27s Coalition responded to thirty years of sectarian violence with a negotiation process based on accommodation, inclusion, and relationship building, concepts that resonate with American-style problem-solving negotiation. Using the Women\u27s Coalition as a case study, this Article suggests that there are procedural aspects of problem-solving negotiation theory that may work across domains, specifically in multi-party, intractable conflict situations, where not all players share the same end game. Topics discussed include: (i) background of the conflict in Northern Ireland, the Troubles , (ii) problem-solving negotiation theory, (iii) strategic approaches of the Women\u27s Coalition during the multi-party negotiations leading to the Good Friday/Belfast Agreement, (iv) perspectives on comparative dispute resolution, and (v) relevance of inclusion, trust and relationship building

Vortex scattering by step topography

The scattering at a rectilinear step change in depth of a shallow-water vortex pair consisting of two patches of equal but opposite-signed vorticity is studied. Using the constants of motion, an explicit relationship is derived relating the angle of incidence to the refracted angle after crossing. A pair colliding with a step from deep water crosses the escarpment and subsequently propagates in shallow water refracted towards the normal to the escarpment. A pair colliding with a step from shallow water either crosses and propagates in deep water refracted away from the normal or, does not cross the step and is instead totally internally reflected by the escarpment. For large depth changes, numerical computations show that the coherence of the vortex pair is lost on encountering the escarpment

A connectionist account of the emergence of the literal-metaphorical-anomalous distinction in young children

We present the first developmental computational model of metaphor comprehension, which seeks to relate the emergence of a distinction between literal and non-literal similarity in young children to the development of semantic representations. The model gradually learns to distinguish literal from metaphorical semantic juxtapositions as it acquires more knowledge about the vehicle domain. In accordance with Keil (1986), the separation of literal from metaphorical comparisons is found to depend on the maturity of the vehicle concept stored within the network. The model generates a number of explicit novel predictions

Exploring the relationships between self-criticism and perfectionism with diabetes-related distress and management in a type 1 diabetes population

Section A: People with a chronic health condition (CHC) are at a greater risk of depression, which can interact with their medical condition and decrease quality of life. Self-criticism correlates with depression and may be factor contributing to poorer outcomes for those with a CHC. This narrative literature review, based on a systematic search, explored, and critiqued 10 papers examining what is known about the relationship with self-criticism and CHCs. The review highlighted that specific antecedent or triggering event that causes the CHC which predisposes the individual to self-criticism is yet to be identified in the current literature, associated with adjustment, symptoms, coping, emotional responses, and functioning and social perceptions amongst those with a CHC. The question remains as to whether selfcriticism impacts directly on physiology or if it acts as a mediator of depressive symptoms in relation to one’s CHC. Section B: The aim of this descriptive study was to develop a greater understanding into the levels of self-criticism in adults with Type 1 Diabetes (T1D), and how this interacts with different types of perfectionism and impacts upon Diabetes-Related Distress (DRD) and diabetes self-management. The findings indicate that maladaptive perfectionism may be an important factor to consider when supporting an individual experiencing DRD and/or struggling with confidence in their diabetes self-management. The study also indicates that the hated-self form of self-criticism may be a more prominent factor in certain forms of DRD. Findings were considered alongside limitations as well as clinical and research implications, such as the need for future research to focus on systemic support experiences of the individual, family and medical systems in the treatment and care of T1D

Atomic spin decoherence near conducting and superconducting films

Published versio