Detailed Stability Analysis of Electroweak Strings

We give a detailed stability analysis of the Z-string in the standard electroweak model. We identify the mode that determines the stability of the string and numerically map the region of parameter space where the string is stable. For $\sin^2 \theta_W = 0.23$, we find that the strings are unstable for a Higgs mass larger than 23GeV. Given the latest constraints on the Higgs mass from LEP, this shows that, if the standard electroweak model is realized in Nature, the existing vortex solutions are unstable.Comment: 18 pages plus one figure (not included but available upon request). To appear in Nuclear Physics

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center.

An amendment to this paper has been published and can be accessed via a link at the top of the paper

LXXIX.?5-Bromoguaiacol and some derivatives

n/

Mother of a problem! : are the needs of mothers with intellectual disability being addressed in the NDIS era?

The National Disability Insurance Scheme was introduced to provide rights-based entitlement support for Australians with disability, replacing the previous welfare-based policy framework. However, there are indications this rights-based support has not eventuated for mothers with intellectual disability, with growing reports of their reduced access to the parenting support to which they are entitled under the Convention on the Rights of Persons with Disability. Despite the NDIS promise of an equitable disability care system that would seamlessly complement State-funded services, reports from mothers with intellectual disability and their advocates suggest that cost-shifting between the Commonwealth and State Governments has reinforced service silos and opened up service gaps for a group of women who need support from both the disability and family support systems. Moreover, a concerning absence of reliable, transparent data makes it difficult to monitor the wellbeing of families headed by mothers with intellectual disability and also suggests these families are no longer a priority for Australian Governments. In this commentary, we advocate for: i) publicly available data on how the NDIS identifies and addresses the support needs of mothers with intellectual disability; ii) the integration of State and Commonwealth funding mechanisms to enable mothers with intellectual disability to access a parenting supplement linked to their NDIS funding and; iii) the rebuilding of national capacity in evidence-based parenting education and support for mothers with intellectual disability across all Australian service systems

Interdisciplinary foundations: Reflecting on interdisciplinarity and three decades of teaching and research at Griffith University, Australia

Interdisciplinarity is widely practised and theorised. However, relatively few studies have reflected on university-wide attempts to foster the concept. This article examines interdisciplinary teaching and learning at Griffith University, Australia. It reflects on the foundations of interdisciplinarity at the university and situates them within the broader context of innovations in worldwide practice; it draws from the literature on interdisciplinarity to traverse the broad understandings of the term; it discusses the Griffith University innovations implemented in support of the concept; and, it reports on the likely outcomes of current methods designed to improve interdisciplinary practice. Whilst challenging barriers to interdisciplinarity continue to exist, compounded by varied conceptions of what interdisciplinarity entails, positiv learning and research outcomes have been accomplished at the university from its interdisciplinary foundations, which also provide a platform to go forward