Effect of Exercise Training on Insulin Sensitivity, Mitochondria and Computed Tomography Muscle Attenuation in Overweight Women With and Without Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is an insulin resistant (IR) state. Increased skeletal muscle lipid content and impaired mitochondrial biogenesis have been implicated in the pathogenesis of IR. We investigated whether differences in these variables explain the IR of women affected by PCOS and whether improvements in IR with exercise are reflected by changes in these variables