394 research outputs found

    A Radon Progeny Deposition Model

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    The next generation low-background detectors operating underground aim for unprecedented low levels of radioactive backgrounds. Although the radioactive decays of airborne radon (particularly Rn-222) and its subsequent progeny present in an experiment are potential backgrounds, also problematic is the deposition of radon progeny on detector materials. Exposure to radon at any stage of assembly of an experiment can result in surface contamination by progeny supported by the long half life (22 y) of Pb-210 on sensitive locations of a detector. An understanding of the potential surface contamination from deposition will enable requirements of radon-reduced air and clean room environments for the assembly of low background experiments. It is known that there are a number of environmental factors that govern the deposition of progeny onto surfaces. However, existing models have not explored the impact of some environmental factors important for low background experiments. A test stand has been constructed to deposit radon progeny on various surfaces under a controlled environment in order to develop a deposition model. Results from this test stand and the resulting deposition model are presented.Comment: Proceedings of the Topical Workshop in Low Radioactivity Techniques, (Sudbury, Canada) August 28-29, 201

    Spermatids do it differently! : Paip2a-the essential regulator of spermiogenesis?

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    The mechanisms underpinning the latter stages of spermiogenesis are poorly understood and male germ cells have been presumed to extensively employ post-transcriptional regulatory machinery, in order to produce the highly differentiated spermatozoa, in the absence of newly synthesized gene transcripts. Excitingly, in a recently published paper in the Journal of Clinical Investigation, two groups at McGill University, using null mouse models, have identified a crucial role of the poly(A)-binding protein-interacting protein 2 (Paip2a), in translational activation and protein homeostasis in the transcriptionally quiescent and terminally differentiating elongating spermatids

    Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc

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    Background: During the development of the Drosophila eye, specific cell types differentiate from an initially equipotent group of uncommitted precursor cells. The lozenge (lz) gene, which is a member of the Runt family of transcriptional regulators, plays a pivotal role in mediating this process through regulating the expression of several fate-specifying transcription factors. However, the regulation of lz, and the control of lz expression levels in different cell types is not fully understood. Results: Here, we show a genetic interaction between Tramtrack69 (Ttk69) a key transcriptional repressor and an inhibitor of neuronal fate specification, and lz, the master patterning gene of cells posterior to the morphogenetic furrow in the Drosophila eye disc. Loss of Ttk69 expression causes the development of ectopic R7 cells in the third instar eye disc, with these cells being dependent upon Lz for their development. Using the binary UAS Gal4 system, we show that overexpression of Ttk69 causes the loss of lz-dependent differentiating cells, and a down-regulation of Lz expression in the developing eye. The loss of lz-dependent cells can be rescued by overexpressing lz via a GMR-lz transgene. We provide additional data showing that factors functioning upstream of Ttk69 in eye development regulate lz in a Ttk69-dependent manner. Conclusions: Our results lead us to conclude that Ttk69 can either directly or indirectly repress lz gene expression to prevent the premature development of R7 precursor cells in the developing eye of Drosophila. We therefore define a mechanism for the tight regulatory control of the master pre-patterning gene, lz, in early Drosophila eye development and provide insight into how differential levels of lz expression can be achieved to effect specific cell fate outcomes

    Flux Qubits and Readout Device with Two Independent Flux Lines

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    We report measurements on two superconducting flux qubits coupled to a readout Superconducting QUantum Interference Device (SQUID). Two on-chip flux bias lines allow independent flux control of any two of the three elements, as illustrated by a two-dimensional qubit flux map. The application of microwaves yields a frequency-flux dispersion curve for 1- and 2-photon driving of the single-qubit excited state, and coherent manipulation of the single-qubit state results in Rabi oscillations and Ramsey fringes. This architecture should be scalable to many qubits and SQUIDs on a single chip.Comment: 5 pages, 4 figures, higher quality figures available upon request. Submitted to PR

    A Natural Framework for Solar and 17 keV Neutrinos

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    Motivated by recent experimental claims for the existence of a 17 keV neutrino and by the solar neutrino problem, we construct a class of models which contain in their low-energy spectrum a single light sterile neutrino and one or more Nambu-Goldstone bosons. In these models the required pattern of breaking of lepton-number symmetry takes place near the electroweak scale and all mass heirarchies are technically natural. The models are compatible with all cosmological and astrophysical constraints, and can solve the solar neutrino problem via either the MSW effect or vacuum oscillations. The deficit in atmospheric muon neutrinos seen in the Kamiokande and IMB detectors can also be explained in these models.Comment: 23 page

    The Cosmic Ray Muon Flux at WIPP

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    In this work a measurement of the muon intensity at the Waste Isolation Pilot Plant (WIPP) near Carlsbad, NM, USA is presented. WIPP is a salt mine with a depth of 655 m. The vertical muon flux was measured with a two panels scintillator coincidence setup to Phi_{vert}=3.10(+0.05/-0.07)*10^(-7)s^(-1)cm^(-2)sr^(-1).Comment: 18 pages, p figure

    Dark matter in the solar system II: WIMP annihilation rates in the Sun

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    We calculate the annihilation rate of weakly interacting massive particles (WIMPs) in the Sun as a function of their mass and elastic scattering cross section. One byproduct of the annihilation, muon neutrinos, may be observed by the next generation of neutrino telescopes. Previous estimates of the annihilation rate assumed that any WIMPs from the Galactic dark halo that are captured in the Sun by elastic scattering off solar nuclei quickly reach thermal equilibrium in the Sun. We show that the optical depth of the Sun to WIMPs and the gravitational forces from planets both serve to decrease the annihilation rate below these estimates. While we find that the sensitivity of upcoming km^3-scale neutrino telescopes to ~100 GeV WIMPs is virtually unchanged from previous estimates, the sensitivity of these experiments to ~10 TeV WIMPs may be an order of magnitude less than the standard calculations would suggest. The new estimates of the annihilation rates should guide future experiment design and improve the mapping from neutrino event rates to WIMP parameter space.Comment: 12 pages, 4 figures, to be submitte
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