423 research outputs found
On Retardation Effects in Space Charge Calculations Of High Current Electron Beams
Laser-plasma accelerators are expected to deliver electron bunches with high
space charge fields. Several recent publications have addressed the impact of
space charge effects on such bunches after the extraction into vacuum.
Artifacts due to the approximation of retardation effects are addressed, which
are typically either neglected or approximated. We discuss a much more
appropriate calculation for the case of laser wakefield acceleration with
negligible retardation artifacts due to the calculation performed in the mean
rest frame. This presented calculation approach also aims at a validation of
other simulation approaches
Experimental estimates of the photon background in a potential light-by-light scattering study
High power short pulse lasers provide a promising route to study the strong field effects of the quantum vacuum, for example by direct photon–photon scattering in the all-optical regime. Theoretical predictions based on realistic laser parameters achievable today or in the near future predict scattering of a few photons with colliding Petawatt laser pulses, requiring single photon sensitive detection schemes and very good spatio-temporal filtering and background suppression. In this article, we present experimental investigations of this photon background by employing only a single high power laser pulse tightly focused in residual gas of a vacuum chamber. The focal region was imaged onto a single-photon sensitive, time gated camera. As no detectable quantum vacuum signature was expected in our case, the setup allowed for characterization and first mitigation of background contributions. For the setup employed, scattering off surfaces of imperfect optics dominated below residual gas pressures of 1 × 10−4 mbar. Extrapolation of the findings to intensities relevant for photon–photon scattering studies is discussed
Ultrasmall divergence of laser-driven ion beams from nanometer thick foils
We report on experimental studies of divergence of proton beams from
nanometer thick diamond-like carbon (DLC) foils irradiated by an intense laser
with high contrast. Proton beams with extremely small divergence (half angle)
of 2 degree are observed in addition with a remarkably well-collimated feature
over the whole energy range, showing one order of magnitude reduction of the
divergence angle in comparison to the results from micrometer thick targets. We
demonstrate that this reduction arises from a steep longitudinal electron
density gradient and an exponentially decaying transverse profile at the rear
side of the ultrathin foils. Agreements are found both in an analytical model
and in particle-in-cell simulations. Those novel features make nm foils an
attractive alternative for high flux experiments relevant for fundamental
research in nuclear and warm dense matter physics.Comment: 11 pages, 5 figure
Partial pharmacologic blockade shows sympathetic connection between blood pressure and cerebral blood flow velocity fluctuations
Cerebral autoregulation (CA) dampens transfer of blood pressure (BP)-fluctuations onto cerebral blood flow velocity (CBFV). Thus, CBFV-oscillations precede BP-oscillations. The phase angle (PA) between sympathetically mediated low-frequency (LF: 0.03–0.15 Hz) BP- and CBFV-oscillations is a measure of CA quality. To evaluate whether PA depends on sympathetic modulation, we assessed PA-changes upon sympathetic stimulation with and without pharmacologic sympathetic blockade.
In 10 healthy, young men, we monitored mean BP and CBFV before and during 120-second cold pressor stimulation (CPS) of one foot (0 °C ice-water). We calculated mean values, standard deviations and sympathetic LF-powers of all signals, and PAs between LF-BP- and LF–CBFV-oscillations. We repeated measurements after ingestion of the adrenoceptor-blocker carvedilol (25 mg). We compared parameters before and during CPS, without and after carvedilol (analysis of variance, post-hoc t-tests, significance: p < 0.05).
Without carvedilol, CPS increased BP, CBFV, BP-LF- and CBFV-LF-powers, and shortened PA. Carvedilol decreased resting BP, CBFV, BP-LF- and CBFV-LF-powers, while PAs remained unchanged. During CPS, BPs, CBFVs, BP-LF- and CBFV-LF-powers were lower, while PAs were longer with than without carvedilol. With carvedilol, CPS no longer shortened resting PA.
Sympathetic activation shortens PA. Partial adrenoceptor blockade abolishes this PA-shortening. Thus, PA-measurements provide a subtle marker of sympathetic influences on CA and might refine CA evaluation
Proton acceleration by irradiation of isolated spheres with an intense laser pulse
We report on experiments irradiating isolated plastic spheres with a peak laser intensity of 2-3 x 10(20) W cm(-2). With a laser focal spot size of 10 mu m full width half maximum (FWHM) the sphere diameter was varied between 520 nm and 19.3 mu m. Maximum proton energies of similar to 25 MeV are achieved for targets matching the focal spot size of 10 mu m in diameter or being slightly smaller. For smaller spheres the kinetic energy distributions of protons become nonmonotonic, indicating a change in the accelerating mechanism from ambipolar expansion towards a regime dominated by effects caused by Coulomb repulsion of ions. The energy conversion efficiency from laser energy to proton kinetic energy is optimized when the target diameter matches the laser focal spot size with efficiencies reaching the percent level. The change of proton acceleration efficiency with target size can be attributed to the reduced cross-sectional overlap of subfocus targets with the laser. Reported experimental observations are in line with 3D3V particle in cell simulations. They make use of well-defined targets and point out pathways for future applications and experiments.DFG via the Cluster of Excellence Munich-Centre for Advanced Photonics (MAP) Transregio SFB TR18NNSA DE-NA0002008Super-MUC pr48meIvo CermakCGC Instruments in design and realization of the Paul trap systemIMPRS-APSLMUexcellent Junior Research FundDAAD|ToIFEEuropean Union's Horizon research and innovation programme 633053Physic
A novel approach to electron data background treatment in an online wide-angle spectrometer for laser-accelerated ion and electron bunches
Laser-based ion acceleration is driven by electrical fields emerging when
target electrons absorb laser energy and consecutively leave the target
material. A direct correlation between these electrons and the accelerated ions
is thus to be expected and predicted by theoretical models. We report on a
modified wide-angle spectrometer allowing the simultaneous characterization of
angularly resolved energy distributions of both ions and electrons. Equipped
with online pixel detectors, the RadEye1 detectors, the investigation of this
correlation gets attainable on a single shot basis. In addition to first
insights, we present a novel approach for reliably extracting the primary
electron energy distribution from the interfering secondary radiation
background. This proves vitally important for quantitative extraction of
average electron energies (temperatures) and emitted total charge
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Stable laser-ion acceleration in the light sail regime
We present experimental results on ion acceleration with circularly polarized, ultrahigh contrast laser pulses focused to peak intensities of 5×1019 W cm-2 onto polymer targets of a few 10 nanometer thickness. We observed spatially and energetically separated protons and carbon ions that accumulate to pronounced peaks around 2 MeV containing as much as 6.5% of the laser energy. Based on particle-in-cell simulation, we illustrate that an early separation of heavier carbon ions and lighter protons creates a stable interface that is maintained beyond the end of the radiation pressure dominated acceleration process
Hereditary sensory and autonomic neuropathies: types II, III, and IV
The hereditary sensory and autonomic neuropathies (HSAN) encompass a number of inherited disorders that are associated with sensory dysfunction (depressed reflexes, altered pain and temperature perception) and varying degrees of autonomic dysfunction (gastroesophageal reflux, postural hypotention, excessive sweating). Subsequent to the numerical classification of four distinct forms of HSAN that was proposed by Dyck and Ohta, additional entities continue to be described, so that identification and classification are ongoing. As a group, the HSAN are rare diseases that affect both sexes. HSAN III is almost exclusive to individuals of Eastern European Jewish extraction, with incidence of 1 per 3600 live births. Several hundred cases with HSAN IV have been reported. The worldwide prevalence of HSAN type II is very low. This review focuses on the description of three of the disorders, HSAN II through IV, that are characterized by autosomal recessive inheritance and onset at birth. These three forms of HSAN have been the most intensively studied, especially familial dysautonomia (Riley-Day syndrome or HSAN III), which is often used as a prototype for comparison to the other HSAN. Each HSAN disorder is likely caused by different genetic errors that affect specific aspects of small fiber neurodevelopment, which result in variable phenotypic expression. As genetic tests are routinely used for diagnostic confirmation of HSAN III only, other means of differentiating between the disorders is necessary. Diagnosis is based on the clinical features, the degree of both sensory and autonomic dysfunction, and biochemical evaluations, with pathologic examinations serving to further confirm differences. Treatments for all these disorders are supportive
Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology
Evaluation of disorders of the autonomic nervous system is both an art and a science, calling upon the physician's most astute clinical skills as well as knowledge of autonomic neurology and physiology. Over the last three decades, the development of noninvasive clinical tests that assess the function of autonomic nerves, the validation and standardization of these tests, and the growth of a large body of literature characterizing test results in patients with autonomic disorders have equipped clinical practice further with a valuable set of objective tools to assist diagnosis and prognosis. This review, based on current evidence, outlines an international expert consensus set of recommendations to guide clinical electrodiagnostic autonomic testing. Grading and localization of autonomic deficits incorporates scores from sympathetic cardiovascular adrenergic, parasympathetic cardiovagal, and sudomotor testing, as no single test alone is sufficient to diagnose the degree or distribution of autonomic failure. The composite autonomic severity score (CASS) is a useful score of autonomic failure that is normalized for age and gender. Valid indications for autonomic testing include generalized autonomic failure, regional or selective system syndromes of autonomic impairment, peripheral autonomic neuropathy and ganglionopathy, small fiber neuropathy, orthostatic hypotension, orthostatic intolerance, syncope, neurodegenerative disorders, autonomic hyperactivity, and anhidrosis
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