362 research outputs found
Star Clusters
This review concentrates almost entirely on globular star clusters. It
emphasises the increasing realisation that few of the traditional problems of
star cluster astronomy can be studied in isolation: the influence of the Galaxy
affects dynamical evolution deep in the core, and the spectrum of stellar
masses; in turn the evolution of the core determines the highest stellar
densities, and the rate of encounters. In this way external tidal effects
indirectly influence the formation and evolution of blue stragglers, binary
pulsars, X-ray sources, etc. More controversially, the stellar density appears
to influence the relative distribution of normal stars. In the opposite sense,
the evolution of individual stars governs much of the early dynamics of a
globular cluster, and the existence of large numbers of primordial binary stars
has changed important details of our picture of the dynamical evolution. New
computational tools which will become available in the next few years will help
dynamical theorists to address these questions.Comment: 10 pages, 3 figures, Te
Far-Ultraviolet Radiation from Elliptical Galaxies
Far-ultraviolet radiation is a ubiquitous, if unanticipated, phenomenon in
elliptical galaxies and early-type spiral bulges. It is the most variable
photometric feature associated with old stellar populations. Recent
observational and theoretical evidence shows that it is produced mainly by
low-mass, small-envelope, helium-burning stars in extreme horizontal branch and
subsequent phases of evolution. These are probably descendents of the dominant,
metal rich population of the galaxies. Their lifetime UV outputs are remarkably
sensitive to their physical properties and hence to the age and the helium and
metal abundances of their parents. UV spectra are therefore exceptionally
promising diagnostics of old stellar populations, although their calibration
requires a much improved understanding of giant branch mass loss, helium
enrichment, and atmospheric diffusion.Comment: 46 pages; includes LaTeX text file, 9 PS figures, 1 JPG figure, 2
style files. Full resolution figures and PS version available at
http://www.astro.virginia.edu/~rwo/araa99/. Article to appear in Annual
Reviews of Astronomy & Astrophysics, 199
The effects of supernovae on the dynamical evolution of binary stars and star clusters
In this chapter I review the effects of supernovae explosions on the
dynamical evolution of (1) binary stars and (2) star clusters.
(1) Supernovae in binaries can drastically alter the orbit of the system,
sometimes disrupting it entirely, and are thought to be partially responsible
for `runaway' massive stars - stars in the Galaxy with large peculiar
velocities. The ejection of the lower-mass secondary component of a binary
occurs often in the event of the more massive primary star exploding as a
supernova. The orbital properties of binaries that contain massive stars mean
that the observed velocities of runaway stars (10s - 100s km s) are
consistent with this scenario.
(2) Star formation is an inherently inefficient process, and much of the
potential in young star clusters remains in the form of gas. Supernovae can in
principle expel this gas, which would drastically alter the dynamics of the
cluster by unbinding the stars from the potential. However, recent numerical
simulations, and observational evidence that gas-free clusters are observed to
be bound, suggest that the effects of supernova explosions on the dynamics of
star clusters are likely to be minimal.Comment: 16 pages, to appear in the 'Handbook of Supernovae', eds. Paul Murdin
and Athem Alsabti. This version replaces an earlier version that contained
several typo
Two distinct sequences of blue straggler stars in the globular cluster M30
Stars in globular clusters are generally believed to have all formed at the
same time, early in the Galaxy's history. 'Blue stragglers' are stars massive
enough that they should have evolved into white dwarfs long ago. Two possible
mechanisms have been proposed for their formation: mass transfer between binary
companions and stellar mergers resulting from direct collisions between two
stars. Recently, the binary explanation was claimed to be dominant. Here we
report that there are two distinct parallel sequences of blue stragglers in
M30. This globular cluster is thought to have undergone 'core collapse', during
which both the collision rate and the mass transfer activity in binary systems
would have been enhanced. We suggest that the two observed sequences arise from
the cluster core collapse, with the bluer population arising from direct
stellar collisions and the redder one arising from the evolution of close
binaries that are probably still experiencing an active phase of mass transfer.Comment: Published on the 24th December 2009 issue of Natur
Dynamical age differences among coeval star clusters as revealed by blue stragglers
Globular star clusters that formed at the same cosmic time may have evolved
rather differently from a dynamical point of view (because that evolution
depends on the internal environment) through a variety of processes that tend
progressively to segregate stars more massive than the average towards the
cluster centre. Therefore clusters with the same chronological age may have
reached quite different stages of their dynamical history (that is, they may
have different dynamical ages). Blue straggler stars have masses greater than
those at the turn-off point on the main sequence and therefore must be the
result of either a collision or a mass-transfer event. Because they are among
the most massive and luminous objects in old clusters, they can be used as test
particles with which to probe dynamical evolution. Here we report that globular
clusters can be grouped into a few distinct families on the basis of the radial
distribution of blue stragglers. This grouping corresponds well to an effective
ranking of the dynamical stage reached by stellar systems, thereby permitting a
direct measure of the cluster dynamical age purely from observed properties.Comment: Published on the 20 December 2012 issue of Natur
Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans
Dopamine is an important neuromodulator in both vertebrates and invertebrates. We have found that reduced dopamine signaling can cause a distinct abnormality in the behavior of the nematode C. elegans, which has only eight dopaminergic neurons. Using an automated particle-tracking system for the analysis of C. elegans locomotion, we observed that individual wild-type animals made small adjustments to their speed to maintain constant rates of locomotion. By contrast, individual mutant animals defective in the synthesis of dopamine made larger adjustments to their speeds, resulting in large fluctuations in their rates of locomotion. Mutants defective in dopamine signaling also frequently exhibited both abnormally high and abnormally low average speeds. The ability to make small adjustments to speed was restored to these mutants by treatment with dopamine. These behaviors depended on the D2-like dopamine receptor DOP-3 and the G-protein subunit GOA-1. We suggest that C. elegans and other animals, including humans, might share mechanisms by which dopamine restricts motor activity levels and coordinates movement
Hyperresponsiveness to inhaled but not intravenous methacholine during acute respiratory syncytial virus infection in mice
BACKGROUND: To characterise the acute physiological and inflammatory changes induced by low-dose RSV infection in mice. METHODS: BALB/c mice were infected as adults (8 wk) or weanlings (3 wk) with 1 × 10(5 )pfu of RSV A2 or vehicle (intranasal, 30 μl). Inflammation, cytokines and inflammatory markers in bronchoalveolar lavage fluid (BALF) and airway and tissue responses to inhaled methacholine (MCh; 0.001 – 30 mg/ml) were measured 5, 7, 10 and 21 days post infection. Responsiveness to iv MCh (6 – 96 μg/min/kg) in vivo and to electrical field stimulation (EFS) and MCh in vitro were measured at 7 d. Epithelial permeability was measured by Evans Blue dye leakage into BALF at 7 d. Respiratory mechanics were measured using low frequency forced oscillation in tracheostomised and ventilated (450 bpm, flexiVent) mice. Low frequency impedance spectra were calculated (0.5 – 20 Hz) and a model, consisting of an airway compartment [airway resistance (Raw) and inertance (Iaw)] and a constant-phase tissue compartment [coefficients of tissue damping (G) and elastance (H)] was fitted to the data. RESULTS: Inflammation in adult mouse BALF peaked at 7 d (RSV 15.6 (4.7 SE) vs. control 3.7 (0.7) × 10(4 )cells/ml; p < 0.001), resolving by 21 d, with no increase in weanlings at any timepoint. RSV-infected mice were hyperresponsive to aerosolised MCh at 5 and 7 d (PC(200 )Raw adults: RSV 0.02 (0.005) vs. control 1.1 (0.41) mg/ml; p = 0.003) (PC(200 )Raw weanlings: RSV 0.19 (0.12) vs. control 10.2 (6.0) mg/ml MCh; p = 0.001). Increased responsiveness to aerosolised MCh was matched by elevated levels of cysLT at 5 d and elevated VEGF and PGE(2 )at 7 d in BALF from both adult and weanling mice. Responsiveness was not increased in response to iv MCh in vivo or EFS or MCh challenge in vitro. Increased epithelial permeability was not detected at 7 d. CONCLUSION: Infection with 1 × 10(5 )pfu RSV induced extreme hyperresponsiveness to aerosolised MCh during the acute phase of infection in adult and weanling mice. The route-specificity of hyperresponsiveness suggests that epithelial mechanisms were important in determining the physiological effects. Inflammatory changes were dissociated from physiological changes, particularly in weanling mice
Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type Diffuse Large B Cell Lymphoma.
Despite the effectiveness of immuno-chemotherapy, 40% of patients with diffuse large B-cell lymphoma (DLBCL) experience relapse or refractory disease. Longitudinal studies have previously focused on the mutational landscape of relapse but falling short of providing a consistent relapse-specific genetic signature. In our study, we have focussed attention on the changes in gene expression profile accompanying DLBCL relapse using archival paired diagnostic/relapse specimens from 38 de novo DLBCL patients. Cell of origin remained stable from diagnosis to relapse in 84% of patients, with only a single patient showing COO switching from ABC to GCB. Analysis of the transcriptomic changes that occur following relapse suggest ABC and GCB relapses are mediated via different mechanisms. We developed a 30-gene discriminator for ABC-DLBCLs derived from relapse-associated genes, that defined clinically distinct high and low risk subgroups in ABC-DLBCLs at diagnosis in datasets comprising both population-based and clinical trial cohorts. This signature also identified a population of <60-year-old patients with superior PFS and OS treated with Ibrutinib-R-CHOP as part of the PHOENIX trial. Altogether this new signature adds to the existing toolkit of putative genetic predictors now available in DLBCL that can be readily assessed as part of prospective clinical trials
Binary and Millisecond Pulsars at the New Millennium
We review the properties and applications of binary and millisecond pulsars.
Our knowledge of these exciting objects has greatly increased in recent years,
mainly due to successful surveys which have brought the known pulsar population
to over 1300. There are now 56 binary and millisecond pulsars in the Galactic
disk and a further 47 in globular clusters. This review is concerned primarily
with the results and spin-offs from these surveys which are of particular
interest to the relativity community.Comment: 59 pages, 26 figures, 5 tables. Accepted for publication in Living
Reviews in Relativity (http://www.livingreviews.org
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