43 research outputs found
Beam characterization and feasibility study for a small animal irradiation platform at clinical proton therapy facilities
A deeper understanding of biological mechanisms to promote more efficient treatment strategies in proton therapy demands advances in preclinical radiation research. However this is often limited by insufficient availability of adequate infrastructures for precision image guided small animal proton irradiation. The project SIRMIO aims at filling this gap by developing a portable image-guided research platform for small animal irradiation, to be used at clinical facilities and allowing for a precision similar to a clinical treatment, when scaled down to the small animal size. This work investigates the achievable dosimetric properties of different lowest energy clinical proton therapy beams, manipulated by a dedicated portable beamline including active focusing after initial beam energy degradation and collimation. By measuring the lateral beam size in air close to the beam nozzle exit and the laterally integrated depth dose in water, an analytical beam model based on the beam parameters of the clinical beam at the Rinecker Proton Therapy Center was created for the lowest available clinical beam energy. The same approach was then applied to estimate the lowest energy beam model of different proton therapy facilities, Paul Scherrer Institute, Centre Antoine Lacassagne, Trento Proton Therapy Centre and the Danish Centre for Particle Therapy, based on their available beam commissioning data. This comparison indicated similar beam properties for all investigated sites, with emittance values of a few tens of mm·mrad. Finally, starting from these beam models, we simulated propagation through a novel beamline designed to manipulate the beam energy and size for precise small animal irradiation, and evaluated the resulting dosimetric properties in water. For all investigated initial clinical beams, similar dosimetric results suitable for small animal irradiation were found. This work supports the feasibility of the proposed SIRMIO beamline, promising suitable beam characteristics to allow for precise preclinical irradiation at clinical treatment facilities
Entwicklung und Herstellung mikrostrukturierter Gasdetektoren für ein präklinisches Protonenbestrahlungssystem
Instrumental performance and results from testing of the BLAST-TNG receiver, submillimeter optics, and MKID arrays
Polarized thermal emission from interstellar dust grains can be used to map
magnetic fields in star forming molecular clouds and the diffuse interstellar
medium (ISM). The Balloon-borne Large Aperture Submillimeter Telescope for
Polarimetry (BLASTPol) flew from Antarctica in 2010 and 2012 and produced
degree-scale polarization maps of several nearby molecular clouds with
arcminute resolution. The success of BLASTPol has motivated a next-generation
instrument, BLAST-TNG, which will use more than 3000 linear polarization
sensitive microwave kinetic inductance detectors (MKIDs) combined with a 2.5m
diameter carbon fiber primary mirror to make diffraction-limited observations
at 250, 350, and 500 m. With 16 times the mapping speed of BLASTPol,
sub-arcminute resolution, and a longer flight time, BLAST-TNG will be able to
examine nearby molecular clouds and the diffuse galactic dust polarization
spectrum in unprecedented detail. The 250 m detector array has been
integrated into the new cryogenic receiver, and is undergoing testing to
establish the optical and polarization characteristics of the instrument.
BLAST-TNG will demonstrate the effectiveness of kilo-pixel MKID arrays for
applications in submillimeter astronomy. BLAST-TNG is scheduled to fly from
Antarctica in December 2017 for 28 days and will be the first balloon-borne
telescope to offer a quarter of the flight for "shared risk" observing by the
community.Comment: Presented at SPIE Millimeter, Submillimeter, and Far-Infrared
Detectors and Instrumentation for Astronomy VIII, June 29th, 201
Optimierung einer neuartigen Strahlführung für Kleintierbestrahlungen an einem klinischen Protonen-Therapiezentrum
Identification of Radiopure Titanium for the LZ Dark Matter Experiment and Future Rare Event Searches
The LUX-ZEPLIN (LZ) experiment will search for dark matter particle
interactions with a detector containing a total of 10 tonnes of liquid xenon
within a double-vessel cryostat. The large mass and proximity of the cryostat
to the active detector volume demand the use of material with extremely low
intrinsic radioactivity. We report on the radioassay campaign conducted to
identify suitable metals, the determination of factors limiting radiopure
production, and the selection of titanium for construction of the LZ cryostat
and other detector components. This titanium has been measured with activities
of U~1.6~mBq/kg, U~0.09~mBq/kg,
Th~~mBq/kg, Th~~mBq/kg, K~0.54~mBq/kg, and Co~0.02~mBq/kg (68\% CL).
Such low intrinsic activities, which are some of the lowest ever reported for
titanium, enable its use for future dark matter and other rare event searches.
Monte Carlo simulations have been performed to assess the expected background
contribution from the LZ cryostat with this radioactivity. In 1,000 days of
WIMP search exposure of a 5.6-tonne fiducial mass, the cryostat will contribute
only a mean background of (stat)(sys) counts.Comment: 13 pages, 3 figures, accepted for publication in Astroparticle
Physic
The LUX-ZEPLIN (LZ) Experiment
We describe the design and assembly of the LUX-ZEPLIN experiment, a direct detection search for cosmic WIMP dark matter particles. The centerpiece of the experiment is a large liquid xenon time projection chamber sensitive to low energy nuclear recoils. Rejection of backgrounds is enhanced by a Xe skin veto detector and by a liquid scintillator Outer Detector loaded with gadolinium for efficient neutron capture and tagging. LZ is located in the Davis Cavern at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. We describe the major subsystems of the experiment and its key design features and requirements
Identification of Radiopure Titanium for the LZ Dark Matter Experiment and Future Rare Event Searches
The LUX-ZEPLIN (LZ) experiment will search for dark matter particle interactions with a detector containing a total of 10 tonnes of liquid xenon within a double-vessel cryostat. The large mass and proximity of the cryostat to the active detector volume demand the use of material with extremely low intrinsic radioactivity. We report on the radioassay campaign conducted to identify suitable metals, the determination of factors limiting radiopure production, and the selection of titanium for construction of the LZ cryostat and other detector components. This titanium has been measured with activities of U~1.6~mBq/kg, U~0.09~mBq/kg, Th~~mBq/kg, Th~~mBq/kg, K~0.54~mBq/kg, and Co~0.02~mBq/kg (68\% CL). Such low intrinsic activities, which are some of the lowest ever reported for titanium, enable its use for future dark matter and other rare event searches. Monte Carlo simulations have been performed to assess the expected background contribution from the LZ cryostat with this radioactivity. In 1,000 days of WIMP search exposure of a 5.6-tonne fiducial mass, the cryostat will contribute only a mean background of (stat)(sys) counts