3,922 research outputs found
The Effectiveness of Information Literacy Instruction at St. Cloud State University: A Lesson in Situated Cognition
In 2006 The Chronicle of Higher Education published an article describing a study completed by the Educational Testing Service (ETS). ETS estimated that only 13% of incoming freshman students were information literate. Studies by Mittermeyer (2005), Wassman (2000), and the Intersegmenatl Committee of the Academic Senates of the California Community Colleges (2002) confirm this diagnosis. Information literacy speaks to the skills of finding, evaluating, and presenting information. Indeed, these skills are crucial in the information age. This paper sought to discover if the for-credit undergraduate information literacy courses (Information Media [IM] 104 and 204) at St. Cloud State University (SCSU) effectively provided students with information literacy skills that are being applied in subsequent courses and/or in the world outside of academia. In discovering the answer to this question, the context in which the instruction was delivered was considered. Learning theorists Jean Lave and Etienne Wenger (1991) developed the theory of situated cognition which suggests that learning is contextual and any knowledge of skills gained through instruction are dependent upon the environment in which they are presented. Therefore, skills learned inside the classroom will not transfer to the outside world unless connections are drawn between the two environments (Anderson, Reder, & Herbert, 1996).
This paper explored the effectiveness of St. Cloud State University\u27s residential, for-credit, undergraduate information literacy courses. Did enrolling in an undergraduate information literacy course at SCSU contribute to graduates being information literate? More specifically, this paper aimed to address the following research questions through the use of a survey: How did the skills and knowledge learned in an information literacy course transfer to subsequent or simultaneous courses, everyday life and the workplace? How did students who enrolled in IM 104 of IM 204 feel about the knowledge and skills gained in the course, particularly if it contributed to their academic success in any way (higher grades, ease of finding credible sources of information for course assignments, etc.) What credible sources of scholarly information (typically those that are peer-reviewed and written by authorities in the field) were students able to identify and locate after taking an information literacy course? How did the students change their information seeking behaviors by looking for scholarly sources for information (electronic databases, Book in Print, credible Web sites, etc., instead of passively surfing the Internet) as a result of enrolling in an information literacy course? Did students use the library and its resources more frequently as a result of taking an information literacy course
The missing piece: Outreach to college/university staff members
Many academic library mission statements include the phrase, “students, faculty, and staff” when referencing the populations that they serve, but how active are we really at reaching out to non-library staff members at our colleges and universities? Libraries typically spend time and energy marketing to students and faculty, but the staff component of our missions can often be overlooked. During the 2012 school year, the Excelsior College librarians implemented three methods to increase staff awareness and use of the library’s resources and services. Through our Community Forum, on-site reference hours in the cafeteria, and virtual brown bags targeting specific staff groups, we are making inroads to actively engage staff members
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Exploring content and psychometric validity of newly developed assessment tools for itch and skin pain in atopic dermatitis.
BackgroundAtopic dermatitis (AD) is a common skin disorder characterized by chronic inflammation, altered skin barrier function, and inflammatory cell skin infiltration that decreases health-related quality of life (HRQoL). The study objective was to understand the patient perspective of AD burden and determine suitable patient-reported outcome (PRO) measures.MethodsThis mixed methods study involved the collection of qualitative and quantitative information from adults (≥ 18 years old) and adolescents (12 - 17 years old) with clinician-confirmed AD regarding their experiences of AD symptoms and its impact on HRQoL. The first part of the study included three stages: in-person concept elicitation (CE) interviews, a 2-week daily electronic diary (eDiary) study, and in-person cognitive debriefing (CD) interviews. An Itch numeric rating scale (NRS) (v1.0) and a Skin Pain NRS (v1.0) evaluation during CD interviews required participants to think about their 'worst' itch and 'worst' skin pain in the past 24 h. Other PRO measures allowed for psychometric testing. The second part of the study involved telephone-depth interviews (TDIs) and qualitative feedback from participants who had not participated in the CD interviews. Qualitative data were thematically analyzed. Psychometric evaluation of NRS measures was performed using eDiary data.ResultsIn the CE interviews, itch and/or itching and skin pain were the most prevalent symptoms consistently discussed by participants. Both NRS measures demonstrated strong psychometric reliability and were applicable across ages with suitable concurrent validity. During the CD interviews, some participants focused their answers on their 'average' itch/itching in the past 24 h, rather than their 'worst' itch. Some participants answered the Skin Pain NRS thinking about general pain or other types of pain, rather than skin pain specifically. Consequently, modifications to both measures addressed these issues and re-tested as paper-and-pen versions in subsequent TDIs. Itch NRS (v2.0) modifications helped participants focus on their worst itching. Most participants preferred Skin Pain NRS v2.0b, which included skin pain descriptors.ConclusionsItching and skin pain are the most important and relevant AD symptoms. The Itch NRS (v2.0) and Skin Pain NRS (v2.0b) appear to be appropriate endpoints for the assessment of itching and skin pain severity for clinical trials with adults and adolescents with AD
Outlook for tuberculosis elimination in California: An individual-based stochastic model.
RationaleAs part of the End TB Strategy, the World Health Organization calls for low-tuberculosis (TB) incidence settings to achieve pre-elimination (<10 cases per million) and elimination (<1 case per million) by 2035 and 2050, respectively. These targets require testing and treatment for latent tuberculosis infection (LTBI).ObjectivesTo estimate the ability and costs of testing and treatment for LTBI to reach pre-elimination and elimination targets in California.MethodsWe created an individual-based epidemic model of TB, calibrated to historical cases. We evaluated the effects of increased testing (QuantiFERON-TB Gold) and treatment (three months of isoniazid and rifapentine). We analyzed four test and treat targeting strategies: (1) individuals with medical risk factors (MRF), (2) non-USB, (3) both non-USB and MRF, and (4) all Californians. For each strategy, we estimated the effects of increasing test and treat by a factor of 2, 4, or 10 from the base case. We estimated the number of TB cases occurring and prevented, and net and incremental costs from 2017 to 2065 in 2015 U.S. dollars. Efficacy, costs, adverse events, and treatment dropout were estimated from published data. We estimated the cost per case averted and per quality-adjusted life year (QALY) gained.Measurements and main resultsIn the base case, 106,000 TB cases are predicted to 2065. Pre-elimination was achieved by 2065 in three scenarios: a 10-fold increase in the non-USB and persons with MRF (by 2052), and 4- or 10-fold increase in all Californians (by 2058 and 2035, respectively). TB elimination was not achieved by any intervention scenario. The most aggressive strategy, 10-fold in all Californians, achieved a case rate of 8 (95% UI 4-16) per million by 2050. Of scenarios that reached pre-elimination, the incremental net cost was 48 billion. These had an incremental cost per QALY of 3.1 million. A more efficient but somewhat less effective single-lifetime test strategy reached as low as $80,000 per QALY.ConclusionsSubstantial gains can be made in TB control in coming years by scaling-up current testing and treatment in non-USB and those with medical risks
A Search for Nitrogen-Enhanced Metal-Poor Stars
Theoretical models of very metal-poor intermediate-mass Asymptotic Giant
Branch (AGB) stars predict a large overabundance of primary nitrogen. The very
metal-poor, carbon-enhanced, s-process-rich stars, which are thought to be the
polluted companions of now-extinct AGB stars, provide direct tests of the
predictions of these models. Recent studies of the carbon and nitrogen
abundances in metal-poor stars have focused on the most carbon-rich stars,
leading to a potential selection bias against stars that have been polluted by
AGB stars that produced large amounts of nitrogen, and hence have small [C/N]
ratios. We call these stars Nitrogen-Enhanced Metal-Poor (NEMP) stars, and
define them as having [N/Fe] > +0.5 and [C/N] < -0.5. In this paper, we report
on the [C/N] abundances of a sample of 21 carbon-enhanced stars, all but three
of which have [C/Fe] < +2.0. If NEMP stars were made as easily as
Carbon-Enhanced Metal-Poor (CEMP) stars, then we expected to find between two
and seven NEMP stars. Instead, we found no NEMP stars in our sample. Therefore,
this observational bias is not an important contributor to the apparent dearth
of N-rich stars. Our [C/N] values are in the same range as values reported
previously in the literature (-0.5 to +2.0), and all stars are in disagreement
with the predicted [C/N] ratios for both low-mass and high-mass AGB stars. We
suggest that the decrease in [C/N] from the low-mass AGB models is due to
enhanced extra-mixing, while the lack of NEMP stars may be caused by
unfavorable mass ratios in binaries or the difficulty of mass transfer in
binary systems with large mass ratios.Comment: 14 pages, 7 figures, to be published in Ap
Development and mixed-methods evaluation of an online animation for young people about genome sequencing
Abstract: Children and young people with rare and inherited diseases will be significant beneficiaries of genome sequencing. However, most educational resources are developed for adults. To address this gap in informational resources, we have co-designed, developed and evaluated an educational resource about genome sequencing for young people. The first animation explains what a genome is, genomic variation and genome sequencing (“My Genome Sequence”: http://bit.ly/mygenomesequence), the second focuses on the limitations and uncertainties of genome sequencing (“My Genome Sequence part 2”: http://bit.ly/mygenomesequence2). In total, 554 school pupils (11–15 years) took part in the quantitative evaluation. Mean objective knowledge increased from before to after watching one or both animations (4.24 vs 7.60 respectively; t = 32.16, p < 0.001). Self-rated awareness and understanding of the words ‘genome’ and ‘genome sequencing’ increased significantly after watching the animation. Most pupils felt they understood the benefits of sequencing after watching one (75.4%) or both animations (76.6%). Only 17.3% felt they understood the limitations and uncertainties after watching the first, however this was higher among those watching both (58.5%, p < 0.001). Twelve young people, 14 parents and 3 health professionals consenting in the 100,000 Genomes Project reported that the animation was clear and engaging, eased concerns about the process and empowered young people to take an active role in decision-making. To increase accessibility, subtitles in other languages could be added, and the script could be made available in a leaflet format for those that do not have internet access. Future research could focus on formally evaluating the animations in a clinical setting
Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats
BACKGROUND: Minocycline, a semi-synthetic tetracycline antibiotic, is an effective neuroprotective agent in animal models of cerebral ischemia when given in high doses intraperitoneally. The aim of this study was to determine if minocycline was effective at reducing infarct size in a Temporary Middle Cerebral Artery Occlusion model (TMCAO) when given at lower intravenous (IV) doses that correspond to human clinical exposure regimens. METHODS: Rats underwent 90 minutes of TMCAO. Minocycline or saline placebo was administered IV starting at 4, 5, or 6 hours post TMCAO. Infarct volume and neurofunctional tests were carried out at 24 hr after TMCAO using 2,3,5-triphenyltetrazolium chloride (TTC) brain staining and Neurological Score evaluation. Pharmacokinetic studies and hemodynamic monitoring were performed on minocycline-treated rats. RESULTS: Minocycline at doses of 3 mg/kg and 10 mg/kg IV was effective at reducing infarct size when administered at 4 hours post TMCAO. At doses of 3 mg/kg, minocycline reduced infarct size by 42% while 10 mg/kg reduced infarct size by 56%. Minocycline at a dose of 10 mg/kg significantly reduced infarct size at 5 hours by 40% and the 3 mg/kg dose significantly reduced infarct size by 34%. With a 6 hour time window there was a non-significant trend in infarct reduction. There was a significant difference in neurological scores favoring minocycline in both the 3 mg/kg and 10 mg/kg doses at 4 hours and at the 10 mg/kg dose at 5 hours. Minocycline did not significantly affect hemodynamic and physiological variables. A 3 mg/kg IV dose of minocycline resulted in serum levels similar to that achieved in humans after a standard 200 mg dose. CONCLUSIONS: The neuroprotective action of minocycline at clinically suitable dosing regimens and at a therapeutic time window of at least 4–5 hours merits consideration of phase I trials in humans in view of developing this drug for treatment of stroke
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