Strategy towards Mirror-fermion Signatures

The existence of mirror fermions interacting strongly under a new gauge group and having masses near the electroweak scale has been recently proposed as a viable alternative to the standard-model Higgs mechanism. The main purpose of this work is to investigate which specific experimental signals are needed to clearly differentiate the mirror-fermion model from other new-physics models. In particular, the case is made for a future large lepton collider with c.o.m. energies of roughly 4 TeV or higher.Comment: 30 Latex pages, 2 postscript figure

AFM pulling and the folding of donor-acceptor oligorotaxanes: phenomenology and interpretation

The thermodynamic driving force in the self-assembly of the secondary structure of a class of donor-acceptor oligorotaxanes is elucidated by means of molecular dynamics simulations of equilibrium isometric single-molecule force spectroscopy AFM experiments. The oligorotaxanes consist of cyclobis(paraquat-\emph{p}-phenylene) rings threaded onto an oligomer of 1,5-dioxynaphthalenes linked by polyethers. The simulations are performed in a high dielectric medium using MM3 as the force field. The resulting force vs. extension isotherms show a mechanically unstable region in which the molecule unfolds and, for selected extensions, blinks in the force measurements between a high-force and a low-force regime. From the force vs. extension data the molecular potential of mean force is reconstructed using the weighted histogram analysis method and decomposed into energetic and entropic contributions. The simulations indicate that the folding of the oligorotaxanes is energetically favored but entropically penalized, with the energetic contributions overcoming the entropy penalty and effectively driving the self-assembly. In addition, an analogy between the single-molecule folding/unfolding events driven by the AFM tip and the thermodynamic theory of first-order phase transitions is discussed and general conditions, on the molecule and the cantilever, for the emergence of mechanical instabilities and blinks in the force measurements in equilibrium isometric pulling experiments are presented. In particular, it is shown that the mechanical stability properties observed during the extension are intimately related to the fluctuations in the force measurements.Comment: 42 pages, 17 figures, accepted to the Journal of Chemical Physic

Relative contribution of three Virginia rivers to spawning activity of striped bass, Morone saxatilis

Initial documentation of spawning activity of striped bass in the tidal freshwater portions of Virginia rivers was provided by Tresselt (1952), Massman et al. (1952, 1962), Rinaldo (1971) and Merriner et al. (1980). Recently, a series of pilot ichthyoplankton surveys of these habitats has resulted in data describing patterns of abundance of eggs and larvae in three separate rivers during three separate years: the Pamunkey and Mattaponi Rivers in spring 1980 (Grant and Olney 1981); the James River in 1981 (Grant and Olney 1982); and the Rappahannock in 1982 (Olney et al. 1983). These surveys were conducted in response to the objectives of the Emergency Striped Bass Study (Chafee Amendment to the Anadromous Fish Act) and have provided spatial and temporal details of spawning activity (Figures 1-4) used in the preparation of management regulations promulgated by the Virginia Marine Resources Commission. more ...

Mini-Survey Of SDSS of [OIII] AGN With Swift

The number of AGN and their luminosity distribution are crucial parameters for our understanding of the AGN phenomenon. Recent work (e.g. Ferrarese and Merritt 2000) strongly suggests every massive galaxy has a central black hole. However, most of these objects either are not radiating or have been very difficult to detect. We are now in the era of large surveys, and the luminosity function (LF) of AGN has been estimated in various ways. In the X-ray band, Chandra and XMM surveys (e.g., Barger et al. 2005; Hasinger, et al. 2005) have revealed that the LF of Hard X-ray selected AGN shows a strong luminosity-dependent evolution with a dramatic break towards low L(x) (at al z). This is seen for all types of AGN, but is stronger for the broad-line objects (e.g., Steffen et al. 2004). In sharp contrast, the local LF of optically-selected samples shows no such break and no differences between narrow and broad-line objects (Hao et al. 2005). If, as been suggested, hard X-ray and optical emission line can both be fair indicators of AGN activity, it is important to first understand how reliable these characteristics are if we hope to understand the apparent discrepancy in the LFs

Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification

<p>Abstract</p> <p>Background</p> <p>During primary infection of its human host, Herpes Simplex Virus Type-1 (HSV-1) establishes latency in neurons where the viral genome is maintained in a circular form associated with nucleosomes in a chromatin configration. During latency, most viral genes are silenced, although the molecular mechanisms responsible for this are unclear. We hypothesized that neuronal factors repress HSV-1 gene expression during latency. A search of the HSV-1 DNA sequence for potential regulatory elements identified a Repressor Element-1/Neuronal Restrictive Silencer Element (RE-1/NRSE) located between HSV-1 genes ICP22 and ICP4. We predicted that the Repressor Element Silencing Transcription Factor/Neuronal Restrictive Silencer Factor (REST/NRSF) regulates expression of ICP22 and ICP4.</p> <p>Results</p> <p>Transient cotransfection indicated that REST/NRSF inhibited the activity of both promoters. In contrast, cotransfection of a mutant form of REST/NRSF encoding only the DNA-binding domain of the protein resulted in less inhibition. Stably transformed cell lines containing episomal reporter plasmids with a chromatin structure showed that REST/NRSF specifically inhibited the ICP4 promoter, but not the ICP22 promoter. REST/NRSF inhibition of the ICP4 promoter was reversed by histone deacetylase (HDAC) inhibitor Trichostatin A (TSA). Additionally, chromatin immuno-precipitation (ChIP) assays indicated that the corepressor CoREST was recruited to the proximity of ICP4 promoter and that acetylation of histone H4 was reduced in the presence of REST/NRSF.</p> <p>Conclusion</p> <p>Since the ICP4 protein is a key transactivator of HSV-1 lytic cycle genes, these results suggest that REST/NRSF may have an important role in the establishment and/or maintenance of HSV-1 gene silencing during latency by targeting ICP4 expression.</p

Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1-Dependent Uncoupling of Endothelial Nitric Oxide Synthase

Endothelial dysfunction is a hallmark of many chronic diseases, including diabetes and long-term hypertension. We show that acute traumatic brain injury (TBI) leads to endothelial dysfunction in rat mesenteric arteries. Endothelial-dependent dilation was greatly diminished 24 h after TBI because of impaired nitric oxide (NO) production. The activity of arginase, which competes with endothelial NO synthase (eNOS) for the common substrate l-arginine, were also significantly increased in arteries, suggesting that arginase-mediated depletion of l-arginine underlies diminished NO production. Consistent with this, substrate restoration by exogenous application of l-arginine or inhibition of arginase recovered endothelial function. Moreover, evidence for increased reactive oxygen species production, a consequence of l-arginine starvation-dependent eNOS uncoupling, was detected in endothelium and plasma. Collectively, our findings demonstrate endothelial dysfunction in a remote vascular bed after TBI, manifesting as impaired endothelial-dependent vasodilation, with increased arginase activity, decreased generation of NO, and increased O(2)(-) production. We conclude that blood vessels have a “molecular memory” of neurotrauma, 24 h after injury, because of functional changes in vascular endothelial cells; these effects are pertinent to understanding the systemic inflammatory response that occurs after TBI even in the absence of polytrauma

Search for positively charged strangelets and other related results with E864 at the AGS

We report on the latest results in the search for positively charged strangelets from E864's 96/97 run at the AGS with sensitivity of about $8\times 10^{-9}$ per central collision. This contribution also contains new results of a search for highly charged strangelets with $Z=+3$. Production of light nuclei, such as $^6He$ and $^6Li$, is presented as well. Measurements of yields of these rarely produced isotopes near midrapidity will help constrain the production levels of strangelets via coalescence. E864 also measures antiproton production which includes decays from antihyperons. Comparisons with antiproton yields measured by E878 as a function of centrality indicate a large antihyperon-to-antiproton ratio in central collisions.Comment: 8 pages, 4 figures; Talk at SQM'98, Padova, Italy (July 20-24th, 1998

Mediation of the solar wind termination shock by non-thermal ions

Broad regions on both sides of the solar wind termination shock are populated by high intensities of non- thermal ions and electrons. The pre- shock particles in the solar wind have been measured by the spacecraft Voyager 1 ( refs 1 - 5) and Voyager 2 ( refs 3, 6). The post- shock particles in the heliosheath have also been measured by Voyager 1 ( refs 3 - 5). It was not clear, however, what effect these particles might have on the physics of the shock transition until Voyager 2 crossed the shock on 31 August - 1 September 2007 ( refs 7 - 9). Unlike Voyager 1, Voyager 2 is making plasma measurements(7). Data from the plasma(7) and magnetic field(8) instruments on Voyager 2 indicate that non- thermal ion distributions probably have key roles in mediating dynamical processes at the termination shock and in the heliosheath. Here we report that intensities of low- energy ions measured by Voyager 2 produce non- thermal partial ion pressures in the heliosheath that are comparable to ( or exceed) both the thermal plasma pressures and the scalar magnetic field pressures. We conclude that these ions are the >0.028 MeV portion of the non- thermal ion distribution that determines the termination shock structure(8) and the acceleration of which extracts a large fraction of bulk- flow kinetic energy from the incident solar wind(7).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62516/1/nature07030.pd