Development of a compact standalone electronic monitor for radon based on a new CMOS system-on-chip

L'exposition du public au gaz radon 222Rn fait l'objet d'une attention croissante. Les méthodes traditionnelles de détection de radon étant soit peu flexibles, soit très chères, cette thèse présente le développement d'un dispositif électronique compact etRadon detection is a long-standing challenge in the field of radioprotection, and the IPHC Institute of Strasbourg has pushed for the development of a fully electronic device, portable and really standalone. Our first prototype of CMOS system-on-chip is

Development of a compact standalone electronic monitor for radon based on a new CMOS system-on-chip

L'exposition du public au gaz radon 222Rn fait l'objet d'une attention croissante. Les méthodes traditionnelles de détection de radon étant soit peu flexibles, soit très chères, cette thèse présente le développement d'un dispositif électronique compact et autonome qui s'appuie sur les progrès récents en microélectronique pour la physique des particules. Le coeur du dispositif est un circuit intégré CMOS original (basse tension, faible consommation) qui assure à la fois les fonctions de capteur et de traitement. Les premiers tests, d'efficacité et en sources de particules alpha, s'appuient sur des simulations détaillées (TRIM, GEANT IV). Différents prototypes de cartes électroniques ont été développés pour d'une part la détection passive de radon à différentes concentrations et d'autre part la détection supplémentaire des descendants sur aérosols 218Po et 214Po qui contribuent de façon importante à l'irradiation a interne".Le système final est une carte miniaturisée au format CB, qui comprend quatre circuits pour la détection simultanée de radon et de ses descendants solides. Une excellente linéarité a été obtenue jusqu à 80 kBq.m-3 sur le banc de test BACCARA au Laboratoire de Mesure des Aérosols de l'IRSN à Saclay. Un circuit de deuxième génération est également proposé.Radon detection is a long-standing challenge in the field of radioprotection, and the IPHC Institute of Strasbourg has pushed for the development of a fully electronic device, portable and really standalone. Our first prototype of CMOS system-on-chip is presented, together with efficiency tests and the corresponding physics simulations (TRIM, GEANT IV). We describe several electronic boards which have been developed for various kinds of tests, firstly passive detection of -particles from gaseous 222Rn in a large spectrum of activity concentrations. In a second stage, active collection of the daughter isotopes 218Po and 214Po was performed: these elements, appearing as attached on the aerosols present in air, are an important contribution to internal -irradiation. The final electronic system, of only 10 cm size, includes four independent chips to ensure simultaneous detection of radon gas and its aerosols. An excellent linearity has been measured up to 80 kBq.m-3 on the BACCARA bench of the IRSN at Saclay. A new generation chip is also studied

Développement d'un dosimètre électronique compact à base de capteurs CMOS pour la mesure du radon

Radon detection is a long-standing challenge in the field of radioprotection, and the IPHC Institute of Strasbourg has pushed for the development of a fully electronic device, portable and really standalone. Our first prototype of CMOS system-on-chip is presented, together with efficiency tests and the corresponding physics simulations (TRIM, GEANT IV). We describe several electronic boards which have been developed for various kinds of tests, firstly passive detection of alpha-particles from gaseous 222Rn in a large spectrum of activity concentrations. In a second stage, active collection of the daughter isotopes 218Po and 214Po was performed: these elements, appearing as attached on the aerosols present in air, are an important contribution to internal alpha-irradiation. The final electronic system, of only 10 cm size, includes four independent chips to ensure simultaneous detection of radon gas and its aerosols. An excellent linearity has been measured up to 80 kBq.m-3 on the BACCARA bench of the IRSN at Saclay. A new generation chip is also studied.L'exposition du public au gaz radon 222Rn fait l'objet d'une attention croissante. Les méthodes traditionnelles de détection de radon étant soit peu flexibles, soit très chères, cette thèse présente le développement d'un dispositif électronique compact et autonome qui s'appuie sur les progrès récents en microélectronique pour la physique des particules. Le coeur du dispositif est un circuit intégré CMOS original (basse tension, faible consommation) qui assure à la fois les fonctions de capteur et de traitement. Les premiers tests, d'efficacité et en sources de particules alpha, s'appuient sur des simulations détaillées (TRIM, GEANT IV). Différents prototypes de cartes électroniques ont été développés pour d'une part la détection passive de radon à différentes concentrations et d'autre part la détection supplémentaire des descendants sur aérosols 218Po et 214Po qui contribuent de façon importante à l'irradiation α interne".Le système final est une carte miniaturisée au format CB, qui comprend quatre circuits pour la détection simultanée de radon et de ses descendants solides. Une excellente linéarité a été obtenue jusqu'à 80 kBq.m-3 sur le banc de test BACCARA au Laboratoire de Mesure des Aérosols de l‘IRSN à Saclay. Un circuit de deuxième génération est également propos

Effets de différents apports nutritionnels en acides gras sur l'action cellulaire de l'acide rétinoïque et de la triiodothyronine dans le foie de rats

BORDEAUX1-BU Sciences-Talence (335222101) / SudocSudocFranceF

Développement d un dosimètre électronique compact à base de capteurs CMOS pour la mesure du radon

L exposition du public au gaz radon 222Rn fait l objet d une attention croissante. Les méthodes traditionnelles de détection de radon étant soit peu flexibles, soit très chères, cette thèse présente le développement d un dispositif électronique compact et autonome qui s appuie sur les progrès récents en microélectronique pour la physique des particules. Le coeur du dispositif est un circuit intégré CMOS original (basse tension, faible consommation) qui assure à la fois les fonctions de capteur et de traitement. Les premiers tests, d efficacité et en sources de particules alpha, s appuient sur des simulations détaillées (TRIM, GEANT IV). Différents prototypes de cartes électroniques ont été développés pour d une part la détection passive de radon à différentes concentrations et d autre part la détection supplémentaire des descendants sur aérosols 218Po et 214Po qui contribuent de façon importante à l irradiation a interne".Le système final est une carte miniaturisée au format CB, qui comprend quatre circuits pour la détection simultanée de radon et de ses descendants solides. Une excellente linéarité a été obtenue jusqu à 80 kBq.m-3 sur le banc de test BACCARA au Laboratoire de Mesure des Aérosols de l IRSN à Saclay. Un circuit de deuxième génération est également proposé.Radon detection is a long-standing challenge in the field of radioprotection, and the IPHC Institute of Strasbourg has pushed for the development of a fully electronic device, portable and really standalone. Our first prototype of CMOS system-on-chip is presented, together with efficiency tests and the corresponding physics simulations (TRIM, GEANT IV). We describe several electronic boards which have been developed for various kinds of tests, firstly passive detection of -particles from gaseous 222Rn in a large spectrum of activity concentrations. In a second stage, active collection of the daughter isotopes 218Po and 214Po was performed: these elements, appearing as attached on the aerosols present in air, are an important contribution to internal -irradiation. The final electronic system, of only 10 cm size, includes four independent chips to ensure simultaneous detection of radon gas and its aerosols. An excellent linearity has been measured up to 80 kBq.m-3 on the BACCARA bench of the IRSN at Saclay. A new generation chip is also studied.STRASBOURG-Sc. et Techniques (674822102) / SudocSudocFranceF

Conception of a New Recoil Proton Telescope for Real-Time Neutron Spectrometry in Proton-Therapy

Neutrons are the main type of secondary particles emitted in proton-therapy. Because of the risk of secondary cancer and other late occurring effects, the neutron dose should be included in the out-of-field dose calculations. A neutron spectrometer has to be used to take into account the energy dependence of the neutron radiological weighting factor. Due to its high dependence on various parameters of the irradiation (beam, accelerator, patient), the neutron spectrum should be measured independently for each treatment. The current reference method for the measurement of the neutron energy, the Bonner Sphere System, consists of several homogeneous polyethylene spheres with increasing diameters equipped with a proportional counter. It provides a highresolution reconstruction of the neutron spectrum but requires a time-consuming work of signal deconvolution. New neutron spectrometers are being developed, but the main experimental limitation remains the high neutron flux in proton therapy treatment rooms. A new model of a real-time neutron spectrometer, based on a Recoil Proton Telescope technology, has been developed at the IPHC. It enables a real-time high-rate reconstruction of the neutron spectrum from the measurement of the recoil proton trajectory and energy. A new fast-readout microelectronic integrated sensor, called FastPixN, has been developed for this specific purpose.A first prototype, able to detect neutrons between 5 and 20 MeV, has already been validated for metrology with the AMANDE facility at Cadarache. The geometry of the new Recoil Proton Telescope has been optimized via extensive Geant4 Monte Carlo simulations. Uncertainty sources have been carefully studied in order to improve simultaneously efficiency and energy resolution, and solutions have been found to suppress the various expected backgrounds. We are currently upgrading the prototype for secondary neutron detection in proton therapy applications

Conception of a New Recoil Proton Telescope for Real-Time Neutron Spectrometry in Proton-Therapy

International audienceNeutrons are the main type of secondary particles emitted in proton-therapy. Because of the risk of secondary cancer and other late occurring effects, the neutron dose should be included in the out-of-field dose calculations. A neutron spectrometer has to be used to take into account the energy dependence of the neutron radiological weighting factor. Due to its high dependence on various parameters of the irradiation (beam, accelerator, patient), the neutron spectrum should be measured independently for each treatment. The current reference method for the measurement of the neutron energy, the Bonner Sphere System, consists of several homogeneous polyethylene spheres with increasing diameters equipped with a proportional counter. It provides a highresolution reconstruction of the neutron spectrum but requires a time-consuming work of signal deconvolution. New neutron spectrometers are being developed, but the main experimental limitation remains the high neutron flux in proton therapy treatment rooms. A new model of a real-time neutron spectrometer, based on a Recoil Proton Telescope technology, has been developed at the IPHC. It enables a real-time high-rate reconstruction of the neutron spectrum from the measurement of the recoil proton trajectory and energy. A new fast-readout microelectronic integrated sensor, called FastPixN, has been developed for this specific purpose. A first prototype, able to detect neutrons between 5 and 20 MeV, has already been validated for metrology with the AMANDE facility at Cadarache. The geometry of the new Recoil Proton Telescope has been optimized via extensive Geant4 Monte Carlo simulations. Uncertainty sources have been carefully studied in order to improve simultaneously efficiency and energy resolution, and solutions have been found to suppress the various expected backgrounds. We are currently upgrading the prototype for secondary neutron detection in proton therapy applications

Detection of thermal neutrons with a CMOS pixel sensor for a future dosemeter

International audienc