The Route of Sir John Franklin's Third Arctic Expedition: An Evaluation and Test of an Alternative Hypothesis

An archaeological survey to aid in the determination of the exact route of the last Sir John Franklin expedition following its overwintering at Beechey Island in 1845-46 was conducted in June 1982. The survey was designed to test the hypothesis that the expedition sailed from Beechey Island south to King William Island via McClintock Channel, rather than through Peel Sound and Franklin Strait, as is generally accepted. Surveyed areas included Kilian, Stefansson, and northeast Victoria Islands in northwest McClintock Channel, and Russell and northern Prince of Wales Islands to the northeast of McClintock Channel. Although three cairns associated with Austin's searching expedition of 1850-51 were located, as well as several prehistoric and historic Inuit sites, no structures or materials associated with the Franklin expedition were identified. While inconclusive, the survey essentially completes the examination of coastlines along which the Franklin expedition may have sailed.Key words: Sir John Franklin, route of third arctic expedition, McClintock ChannelEn juin 1982, on a effectué une étude archéologique destinée à permettre de retracer la route empruntée par la dernière expédition de sir John Franklin après le long hivernage de 1845-46 à l'île Beechey. L'étude avait pour but de vérifier l'hypothèse selon laquelle l'expédition avait navigué de l'île Beechey en direction du sud vers l'île du Roi-Guillaume via le chenal McClintock, plutôt qu'à travers le détroit de Peel et celui de Franklin, comme on le pense habituellement. Les régions de l'étude comprenaient les îles Kilian et Stefansson et le nord-est de l'île Victoria dans la partie nord-ouest du chenal McClintock, ainsi que l'île Russell et la partie septentrionale de l'île du Prince-de-Galles au nord-est du chenal McClintock. Bien qu'on ait localisé trois cairns datant de l'expédition de recherche menée par Austin en 1850-51, ainsi que divers sites inuit préhistoriques et historiques, on n'a pu identifier ni structure ni matériaux remontant à l'expédition Franklin. Si l'étude n'a pas abouti à une conclusion définitive, elle a du moins permis de compléter l'examen du rivage côtier le long duquel l'expédition Franklin a pu naviguer.Mots clés: sir John Franklin, route de la troisième expédition arctique, chenal McClintoc

Identification of constrained sequence elements across 239 primate genomes

Noncoding DNA is central to our understanding of human gene regulation and complex diseases1,2, and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in the human genome3–9. Identifying the genomic elements that have become constrained specifically in primates has been hampered by the faster evolution of noncoding DNA compared to protein-coding DNA10, the relatively short timescales separating primate species11, and the previously limited availability of whole-genome sequences12. Here we construct a whole-genome alignment of 239 species, representing nearly half of all extant species in the primate order. Using this resource, we identified human regulatory elements that are under selective constraint across primates and other mammals at a 5% false discovery rate. We detected 111,318 DNase I hypersensitivity sites and 267,410 transcription factor binding sites that are constrained specifically in primates but not across other placental mammals and validate their cis-regulatory effects on gene expression. These regulatory elements are enriched for human genetic variants that affect gene expression and complex traits and diseases. Our results highlight the important role of recent evolution in regulatory sequence elements differentiating primates, including humans, from other placental mammals

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Maastricht Delphi consensus on event definitions for classification of recurrence in breast cancer research

Background In breast cancer studies, many different endpoints are used. Definitions are often not provided or vary between studies. For instance, "local recurrence" may include different components in similar studies. This limits transparency and comparability of results. This project aimed to reach consensus on the definitions of local event, second primary breast cancer, regional and distant event for breast cancer studies

Identification of constrained sequence elements across 239 primate genomes

Noncoding DNA is central to our understanding of human gene regulation and complex diseases and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in the human genome. Identifying the genomic elements that have become constrained specifically in primates has been hampered by the faster evolution of noncoding DNA compared to protein-coding DNA10, the relatively short timescales separating primate species, and the previously limited availability of whole-genome sequences12. Here we construct a whole-genome alignment of 239 species, representing nearly half of all extant species in the primate order. Using this resource, we identified human regulatory elements that are under selective constraint across primates and other mammals at a 5% false discovery rate. We detected 111,318 DNase I hypersensitivity sites and 267,410 transcription factor binding sites that are constrained specifically in primates but not across other placental mammals and validate their cis-regulatory effects on gene expression. These regulatory elements are enriched for human genetic variants that affect gene expression and complex traits and diseases. Our results highlight the important role of recent evolution in regulatory sequence elements differentiating primates, including humans, from other placental mammals