Collaborative Aerospace Research and Fellowship Program at NASA Glenn Research Center

During the summer of 2004, a 10-week activity for university faculty entitled the NASA-OAI Collaborative Aerospace Research and Fellowship Program (CFP) was conducted at the NASA Glenn Research Center in collaboration with the Ohio Aerospace Institute (OAI). This is a companion program to the highly successful NASA Faculty Fellowship Program and its predecessor, the NASA-ASEE Summer Faculty Fellowship Program that operated for 38 years at Glenn. The objectives of CFP parallel those of its companion, viz., (1) to further the professional knowledge of qualified engineering and science faculty,(2) to stimulate an exchange of ideas between teaching participants and employees of NASA, (3) to enrich and refresh the research and teaching activities of participants institutions, and (4) to contribute to the research objectives of Glenn. However, CFP, unlike the NASA program, permits faculty to be in residence for more than two summers and does not limit participation to United States citizens. Selected fellows spend 10 weeks at Glenn working on research problems in collaboration with NASA colleagues and participating in related activities of the NASA-ASEE program. This year's program began officially on June 1, 2004 and continued through August 7, 2004. Several fellows had program dates that differed from the official dates because university schedules vary and because some of the summer research projects warranted a time extension beyond the 10 weeks for satisfactory completion of the work. The stipend paid to the fellows was $1200 per week and a relocation allowance of$1000 was paid to those living outside a 50-mile radius of the Center. In post-program surveys from this and previous years, the faculty cited numerous instances where participation in the program has led to new courses, new research projects, new laboratory experiments, and grants from NASA to continue the work initiated during the summer. Many of the fellows mentioned amplifying material, both in undergraduate and graduate courses, on the basis of the summer s experience at Glenn. A number of 2004 fellows indicated that proposals to NASA will grow out of their summer research projects. In addition, some journal articles and NASA publications will result from this past summer s activities. Fellows from past summers continue to send reprints of articles that resulted from work initiated at Glenn. This report is intended primarily to summarize the research activities comprising the 2004 CFP Program at Glenn. Particular research studies include: 1) Development of an Imaging-Based, Computational Fluid Dynamics Tool to Assess Fluid Mechanics in Experimental Models that Simulate Blood Vessels; 2) Analysis of Nanomaterials Produced from Precursors; and 3) LEO Propagation Analysis Tool

REFLECTION OF PRESSURE WAVES AT FLOW IN ELASTIC TUBES

The field of climate change communication (CCC) has recently emerged to address the gap between scientific knowledge of climate change and public motivation to respond. Psychologists in this field have offered helpful strategies for improving the effectiveness of CCC, but their empirical research tends to neglect the ethics of CCC. Philosophers have been more attentive to ethical communication, but they tend to focus on its cognitive dimensions and minimize the affective and social dimensions that contribute to effectiveness. As a result, studies that address ethics and effectiveness in tandem are lacking. This chapter fills this gap by recovering insights from Aristotle’s Rhetoric. By situating all communication within an ethical relationship between speaker and auditor, emphasizing the agency and judgement of auditors, and highlighting ways to build trust, Aristotle offers an art of rhetoric that can help climate scientists communicate both ethically and effectively

Numerical arc segmentation algorithm for a radio conference: A software tool for communication satellite systems planning

The Numerical Arc Segmentation Algorithm for a Radio Conference (NASARC) provides a method of generating predetermined arc segments for use in the development of an allotment planning procedure to be carried out at the 1988 World Administrative Radio Conference (WARC) on the Use of the Geostationary Satellite Orbit and the Planning of Space Services Utilizing It. Through careful selection of the predetermined arc (PDA) for each administration, flexibility can be increased in terms of choice of system technical characteristics and specific orbit location while reducing the need for coordination among administrations. The NASARC software determines pairwise compatibility between all possible service areas at discrete arc locations. NASARC then exhaustively enumerates groups of administrations whose satellites can be closely located in orbit, and finds the arc segment over which each such compatible group exists. From the set of all possible compatible groupings, groups and their associated arc segments are selected using a heuristic procedure such that a PDA is identified for each administration. Various aspects of the NASARC concept and how the software accomplishes specific features of allotment planning are discussed

Closing the circle: is it feasible to rehabilitate reefs with sexually propagated corals?

Sexual propagation of corals specifically for reef rehabilitation remains largely experimental. In this study, we refined low technology culture and transplantation approaches and assessed the role of colony size and age, at time of transfer from nursery to reef, on subsequent survival. Larvae from Acropora millepora were reared from gametes and settled on engineered substrates, called coral plug-ins, that were designed to simplify transplantation to areas of degraded reef. Plug-ins, with laboratory spawned and settled coral recruits attached, were maintained in nurseries until they were at least 7 months old before being transplanted to replicate coral limestone outcrops within a marine protected area until they were 31 months old. Survival rates of transplanted corals that remained at the protected in situ nursery the longest were 3.9–5.6 times higher than corals transplanted to the reef earlier, demonstrating that an intermediate ocean nursery stage is critical in the sexual propagation of corals for reef rehabilitation. 3 years post-settlement, colonies were reproductively mature, making this one of few published studies to date to rear a broadcasting scleractinian from eggs to spawning adults. While our data show that it is technically feasible to transplant sexually propagated corals and rear them until maturity, producing a single 2.5-year-old coral on the reef cost at least US$60. ‘What if’ scenarios indicate that the cost per transplantable coral could be reduced by almost 80 %, nevertheless, it is likely that the high cost per coral using sexual propagation methods would constrain delivery of new corals to relatively small scales in many countries with coral reefs.Published versio

Neutralizing antibody response during acute and chronic hepatitis C virus infection

Little is known about the role of Abs in determining the outcome of hepatitis C virus (HCV) infection. By using infectious retroviral pseudotypes bearing HCV glycoproteins, we measured neutralizing Ab (nAb) responses during acute and chronic HCV infection. In seven acutely infected health care workers, only two developed a nAb response that failed to associate with viral clearance. In contrast, the majority of chronically infected patients had nAbs. To determine the kinetics of strain-specific and crossreactive nAb emergence, we studied patient H, the source of the prototype genotype 1a H77 HCV strain. An early weak nAb response, specific for the autologous virus, was detected at seroconversion. However, neutralization of heterologous viruses was detected only between 33 and 111 weeks of infection. We also examined the development of nAbs in 10 chimpanzees infected with H77 clonal virus. No nAb responses were detected in three animals that cleared virus, whereas strain-specific nAbs were detected in six of the seven chronically infected animals after approximately 50 weeks of infection. The delayed appearance of high titer crossreactive nAbs in chronically infected patients suggests that selective mechanism(s) may operate to prevent the appearance of these Abs during acute infection. The long-term persistence of these nAbs in chronically infected patients may regulate viral replication

Tachykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Tachykinin receptors (provisional nomenclature as recommended by NC-IUPHAR [90]) are activated by the endogenous peptides substance P (SP), neurokinin A (NKA; previously known as substance K, neurokinin α, neuromedin L), neurokinin B (NKB; previously known as neurokinin β, neuromedin K), neuropeptide K and neuropeptide γ (N-terminally extended forms of neurokinin A). The neurokinins (A and B) are mammalian members of the tachykinin family, which includes peptides of mammalian and nonmammalian origin containing the consensus sequence: Phe-x-Gly-Leu-Met. Marked species differences in in vitro pharmacology exist for all three receptors, in the context of nonpeptide ligands. Antagonists such as aprepitant and fosaprepitant were approved by FDA and EMA, in combination with other antiemetic agents, for the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy