1,065 research outputs found

    Observations of the solar plasma using radio scattering and scintillation methods

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    Observations of the solar plasma using the interplanetary scintillation technique have been made at radial distances of 0.03 to 1.2 AU. The solar wind is found to be independent of ecliptic latitude and radial distance, except close to the sun where acceleration is observed. Plasma density irregularities on a scale near the proton gyro radius, which modulate the mean density by about 1 percent, are present throughout the observed range of radial distance

    Making sense of academic life in the UK: The voice of the direct entry student at UWE

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    The academic experiences of a small group of direct entry international students were recorded by a cross-service/faculty project group at the University of the West of England. Findings showed that more could be done to inform prospective students about their course and the different academic culture they would experience. In response to the student interviews, the project team compiled recommendations and a toolkit for staff which focused on transition, teaching and learning, and academic support. Progress has included the introduction of pre-arrival tasks across all faculties and the formation of a cross-service International Student Experience Group

    Fine Structure in Radio Sources at 81.5 MHz-III: The Survey

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    A survey of radio sources which exhibit interplanetary scintillations has been carried out with the Cambridge 18 000 m² array at 81.5 MHz. The methods of observation, and of determination of angular structure on a scale 0″.2 to 2″.0, are discussed and a catalogue lists the structure of ∼ 1500 4C sources between declinations −12° and +90°, roughly 60 per cent of which scintillate. An analysis of the results will be presented elsewhere

    Fine Structure in Radio Sources at 81.5 MHz-III: The Survey

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    A survey of radio sources which exhibit interplanetary scintillations has been carried out with the Cambridge 18 000 m² array at 81.5 MHz. The methods of observation, and of determination of angular structure on a scale 0″.2 to 2″.0, are discussed and a catalogue lists the structure of ∼ 1500 4C sources between declinations −12° and +90°, roughly 60 per cent of which scintillate. An analysis of the results will be presented elsewhere

    The Gaussian Plasma Lens in Astrophysics. Refraction

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    We consider the geometrical optics for refraction of a distant radio source by an interstellar plasma lens, with application to a lens with a Gaussian electron column density profile. The refractive properties of the lens are specified completely by a dimensionless parameter, alpha, which is a function of the wavelength of observation, the lens' electron column density, the lens-observer distance, and the transverse diameter of the lens. Relative motion of the observer and lens produces modulations in the source's light curve. Plasma lenses are diverging so the light curve displays a minimum, when the lens is on-axis, surrounded by enhancements above the unlensed flux density. Lensing can also produce caustics, multiple imaging, and angular position wander of the background source. If caustics are formed, the separation of the outer caustics can constrain alpha, while the separation of the inner caustics can constrain the size of the lens. We apply our analysis to 0954+654, a source for which we can identify caustics in its light curve, and 1741-038, for which polarization observations were obtained during and after the scattering event. We find general agreement between modelled and observed light curves at 2.25 GHz, but poor agreement at 8.1 GHz. The discrepancies may result from a combination of lens substructure or anisotropic shape, a lens that only grazes the source, or unresolved source substructure. Our analysis places the following constraints on the lenses: Toward 0954+654 (1741-038) the lens was 0.38 AU (0.065 AU) in diameter, with a peak column density of 0.24 pc cm^{-3} (1E-4 pc cm^{-3}) and an electron density of 1E5 cm^{-3} (300 cm^{-3}). The angular wander caused by the lens was 250 mas (0.4 mas) at 2.25 GHz. For 1741-038, we place an upper limit of 100 mG on the lens' magnetic field.Comment: 26 pages, LaTeX2e using AASTeX macro aaspp4, 11 PostScript figures; to be published in Ap

    Severe synergistic toxicity from docetaxel in a patient treated concurrently with protease inhibitors as part of HIV post-exposure prophylaxis: a case report

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    <p>Abstract</p> <p>Introduction</p> <p>Docetaxel is a semisynthetic taxane commonly used in solid tumour oncology. Its pharmacokinetics has been widely studied, and it is well established that it is metabolized to pharmacologically inactive products by the cytochrome P450 3A iso-enzymes. However, there have been few reports of the consequences of drug interactions between taxanes and other drugs metabolized by the cytochrome P450 pathway. To the best of our knowledge, this is the first case report of the potentially life-threatening interaction that can occur between docetaxel and the protease inhibitors lopinavir and ritonavir.</p> <p>Case presentation</p> <p>A 30-year-old Caucasian woman presented with symptoms suggestive of severe docetaxel toxicity, that is, prolonged myelosuppression, grade 4 mucositis and desquamating rash, following the commencement of post-exposure prophylaxis for a needlestick injury. She had previously received docetaxel chemotherapy with minimal side effects.</p> <p>Conclusion</p> <p>This case report highlights a probable and novel drug interaction between docetaxel and lopinavir and/or ritonavir, which is largely unreported in the medical literature. Even though these interactions may be more relevant in the field of HIV medicine, knowledge of these interactions is also beneficial to oncologists and dermatologists, as well as those providing acute medical care.</p

    The spectrum of small-scale density fluctuations in the solar wind

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    Interplanetary scintillation observations at frequencies between 74 and 1400 MHz and solar elongations in the range 10–90° are combined to determine the form of the wavenumber spectrum of electron density fluctuations in the range 10⁻³ < k < 10⁻¹/km (where k = 2π/λ). The data are best explained by a spectrum in which there is a genuine scale-length; they are not consistent with a simple power-law spectrum. This suggests that turbulence may be less important than some kind of plasma instability in generating small-scale density fluctuations. The relevance of these conclusions to the use of IPS for determining radio source structure is discussed

    On the Enhanced Interstellar Scattering Toward B1849+005

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    (Abridged) This paper reports new Very Large Array (VLA) and Very Long Baseline Array (VLBA) observations of the extragalactic source B1849+005 at frequencies between 0.33 and 15 GHz and the re-analysis of archival VLA observations at 0.33, 1.5, and 4.9 GHz. The structure of this source is complex but interstellar scattering dominates the structure of the central component at least to 15 GHz. An analysis of the phase structure functions of the interferometric visibilities shows the density fluctuations along this line of sight to be anisotropic (axial ratio = 1.3) with a frequency-independent position angle, and having an inner scale of roughly a few hundred kilometers. The anisotropies occur on length scales of order 10^{15} cm (D/5 kpc), which within the context of certain magnetohydrodynamic turbulence theories indicates the length scale on which the kinetic and magnetic energy densities are comparable. A conservative upper limit on the velocity of the scattering material is 1800 km/s. In the 0.33 GHz field of view, there are a number of other sources that might also be heavily scattered. Both B1849+005 and PSR B1849+00 are highly scattered, and they are separated by only 13'. If the lines of sight are affected by the same ``clump'' of scattering material, it must be at least 2.3 kpc distant. However, a detailed attempt to account for the scattering observables toward these sources does not produce a self-consistent set of parameters for such a clump. A clump of H\alpha emission, possibly associated with the H II region G33.418-0.004, lies between these two lines of sight, but it seems unable to account for all of the required excess scattering.Comment: 23 pages, LaTeX2e AASTeX, 13 figures in 14 PostScript files, accepted for publication in Ap

    Modeling of Interstellar Scintillation Arcs from Pulsar B1133+16

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    The parabolic arc phenomenon visible in the Fourier analysis of the scintillation spectra of pulsars provides a new method of investigating the small scale structure in the ionized interstellar medium (ISM). We report archival observations of the pulsar B1133+16 showing both forward and reverse parabolic arcs sampled over 14 months. These features can be understood as the mutual interference between an assembly of discrete features in the scattered brightness distribution. By model-fitting to the observed arcs at one epoch we obtain a ``snap-shot'' estimate of the scattered brightness, which we show to be highly anisotropic (axial ratio >10:1), to be centered significantly off axis and to have a small number of discrete maxima, which are coarser the speckle expected from a Kolmogorov spectrum of interstellar plasma density. The results suggest the effects of highly localized discrete scattering regions which subtend 0.1-1 mas, but can scatter (or refract) the radiation by angles that are five or more times larger.Comment: 14 pages, 4 figures, submitted to Astrophysical Journa

    Electric field representation of pulsar intensity spectra

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    Pulsar dynamic spectra exhibit high visibility fringes arising from interference between scattered radio waves. These fringes may be random or highly ordered patterns, depending on the nature of the scattering or refraction. Here we consider the possibility of decomposing pulsar dynamic spectra -- which are intensity measurements -- into their constituent scattered waves, i.e. electric field components. We describe an iterative method of achieving this decomposition and show how the algorithm performs on data from the pulsar B0834+06. The match between model and observations is good, although not formally acceptable as a representation of the data. Scattered wave components derived in this way are immediately useful for qualitative insights into the scattering geometry. With some further development this approach can be put to a variety of uses, including: imaging the scattering and refracting structures in the interstellar medium; interstellar interferometric imaging of pulsars at very high angular resolution; and mitigating pulse arrival time fluctuations due to interstellar scattering.Comment: 7 Pages, 2 Figures, revised version, accepted by MNRA
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