2D Yang-Mills Theory as a Matrix String Theory

Quantization of two-dimensional Yang-Mills theory on a torus in the gauge where the field strength is diagonal leads to twisted sectors that are completely analogous to the ones that originate long string states in Matrix String Theory. If these sectors are taken into account the partition function is different from the standard one found in the literature and the invariance of the theory under modular transformations of the torus appears to hold in a stronger sense. The twisted sectors are in one-to-one correspondence with the coverings of the torus without branch points, so they define by themselves a string theory. A possible duality between this string theory and the Gross-Taylor string is discussed, and the problems that one encounters in generalizing this approach to interacting strings are pointed out. This talk is based on a previous paper by the same authors, but it contains some new results and a better interpretation of the results already obtained.Comment: 11 pages, LaTeX, 2 figures included with epsf. Talk presented at the 2nd Conference on Quantum aspects of Gauge Theories, Supersymmetry and Unification, Corfu, Greece, 21-26 September 199

Treatment-resistant depression in adolescents: is the addition of cognitive behavioral therapy of benefit?

BACKGROUND: Many young people with major depression fail first-line treatments. Treatment-resistant depression has various definitions in the literature but typically assumes nonresponse to medication. In young people, cognitive behavioral therapy (CBT) is the recommended first-line intervention, thus the definition of treatment resistance should be expanded. Therefore, our aim was to synthesize the existing evidence of any interventions for treatment-resistant depression, broadly defined, in children and adolescents and to investigate the effectiveness of CBT in this context. METHODS: We used Cochrane Collaboration methodology, with electronic searches of Medline, PsycINFO, Embase, and the Cochrane Depression Anxiety and Neurosis Group trials registers. Only randomized controlled trials were included, and were assessed for risk of bias. Meta- analysis was undertaken where possible and appropriate. RESULTS: Of 953 articles retrieved, four trials were eligible for inclusion. For one study, only the trial registration document was available, because the study was never completed. All other studies were well conducted with a low risk of bias, although one study had a high dropout rate. Two studies assessed the effect of adding CBT to medication. While an assertive trial of antidepressants does appear to lead to benefit, when compared with placebo, there was no significant advantage, in either study, or in a meta-analysis of data from these trials, that clearly demonstrated an additional benefit of CBT. The third trial showed little advantage of a tricyclic antidepressant over placebo in the context of an inpatient admission. CONCLUSION: Few randomized controlled trials have investigated interventions for treatment-resistant depression in young people, and results from these show modest benefit from antidepressants with no additional benefit over medication from CBT. Overall, there is a lack of evidence about effective interventions to treat young people who have failed to respond to evidence-based interventions for depression. Research in this area is urgently required

Heavy-Light Decay Constants: Conclusions from the Wilson Action

We report on the results of a MILC collaboration calculation of $f_B$, $f_{B_s}$, $f_D$, $f_{D_s}$ and their ratios. We discuss the most important errors in more detail than we have elsewhere.Comment: LATTICE98(heavyqk) 3 latex pages and 3 postscript figures. The perturbative correction calculated by Kuramashi has been adjusted to take into account the fact that we match to the continuum at the kinetic mass of the heavy meson, not the pole mass. This produces a 2 to 4 MeV change in final results for decay constants, and has negligible effect on decay constant ratio

Instantons and the Ground State of the Massive Schwinger Model

We study the massive Schwinger model, quantum electrodynamics of massive, Dirac fermions, in 1+1 dimensions; with space compactified to a circle. In the limit that transitions to fermion--anti-fermion pairs can be neglected, we study the full ground state. We focus on the effect of instantons which mediate tunnelling transitions in the induced potential for the dynamical degree of freedom in the gauge field.Comment: 17 pages, plain te

Chiral Symmetry Breaking on the Lattice: a Study of the Strongly Coupled Lattice Schwinger Model

We revisit the strong coupling limit of the Schwinger model on the lattice using staggered fermions and the hamiltonian approach to lattice gauge theories. Although staggered fermions have no continuous chiral symmetry, they posses a discrete axial invari ance which forbids fermion mass and which must be broken in order for the lattice Schwinger model to exhibit the features of the spectrum of the continuum theory. We show that this discrete symmetry is indeed broken spontaneously in the strong coupling li mit. Expanding around a gauge invariant ground state and carefully considering the normal ordering of the charge operator, we derive an improved strong coupling expansion and compute the masses of the low lying bosonic excitations as well as the chiral co ndensate of the model. We find very good agreement between our lattice calculations and known continuum values for these quantities already in the fourth order of strong coupling perturbation theory. We also find the exact ground state of the antiferromag netic Ising spin chain with long range Coulomb interaction, which determines the nature of the ground state in the strong coupling limit.Comment: 24 pages, Latex, no figure

Symanzik flow on HISQ ensembles

We report on a scale determination with gradient-flow techniques on the $N_f = 2 + 1 + 1$ HISQ ensembles generated by the MILC collaboration. The lattice scale $w_0/a$, originally proposed by the BMW collaboration, is computed using Symanzik flow at four lattice spacings ranging from 0.15 to 0.06 fm. With a Taylor series ansatz, the results are simultaneously extrapolated to the continuum and interpolated to physical quark masses. We give a preliminary determination of the scale $w_0$ in physical units, along with associated systematic errors, and compare with results from other groups. We also present a first estimate of autocorrelation lengths as a function of flowtime for these ensembles.Comment: 7 pages, 6 pdf figures, 2 tables, presented at the 31st International Symposium on Lattice Field Theory (Lattice 2013), 29 July - 3 August 2013, Mainz, German

Relationships between auditory event-related potentials and mood state, medication, and comorbid psychiatric illness in patients with bipolar disorder

BACKGROUND: Patients with bipolar disorder (BD) exhibit aberrations in auditory event-related potentials (ERPs), although the relationships between these measures and mood state at testing, comorbid psychiatric illness, presence of psychotic features, and medication usage are unclear. The purpose of this study was to investigate the relationships between these factors and auditory ERP measures in BD patients. METHODS: An auditory 'oddball' discrimination task was used to elicit ERPs from 69 patients with type I BD and 52 healthy controls. Patients were placed into subgroups based upon their mood state at testing (euthymic or symptomatic), and ANOVA was used to compare amplitude and peak latency measures from the N100, P200, N200, and P300 ERP components across subgroups. Multiple regression was used to investigate relationships between ERP measures and comorbid psychiatric diagnosis, history of psychotic features, and medication status. RESULTS: Relative to healthy control participants, euthymic and symptomatic BD patients exhibited reduced P300 and P200 amplitude, but ERP measures did not differ among BD patients on the basis of mood status. A history of a comorbid anxiety disorder was associated with reduced N200 peak latency, but prolonged P300 peak latency among BD patients. No other relationships between clinical variables and ERP measures were significant. CONCLUSIONS: The results suggest that disrupted auditory attention may be observed in BD patients regardless of their mood state at testing, medication status, or history of psychosis. These results extend previous findings, and provide further evidence for aberrations in the P300 ERP as an endophenotype for BD

Juegos serios para el tratamiento o la prevención de la depresión: una revisión sistemática

Serious games (computerised interventions which utilise gaming for serious purposes) have been shown to support improved outcomes in several health conditions. We aimed to review evidence regarding serious games for depression. We undertook electronic searches of PsycInfo, EMBASE and Medline, using terms relevant to computer games and depression. We included fulltext articles published in English in peer-reviewed literature since 2000, where the intervention was designed to treat or prevent depression and which included pre-and post-intervention measurement of depression. Nine studies relating to a total of six interventions met inclusion criteria. Most studies were small and were carried out by the developers of the programs. All were tested with young people (ages between 9 and 25 years). Most reported promising results with some positive impact on depression although one universal program had mixed results. Serious gaming interventions show promise for depression, however evidence is currently very limited.Se ha demostrado que los juegos serios (intervenciones computarizadas que utilizan juegos) mejoran los resultados en diferentes problemas de salud. Pretendemos examinar las evidencias de estos juegos para la depresión. Se realizaron búsquedas electrónicas en PsycINFO, EMBASE y Medline usando términos relacionados con juegos de ordenador y depresión. Se incluyeron artículos publicados desde el año 2000, donde se diseñó la intervención para tratar o prevenir la depresión incluyendo medidas pre- y post-intervención. Nueve estudios sobre un total de seis intervenciones cumplieron los criterios de inclusión. La mayoría de estos fueron pequeños y los llevaron a cabo los desarrolladores de los programas. Todos incluían población joven (9 - 25 años). La mayoría presentan resultados prometedores con un impacto positivo sobre la depresión aunque un programa universal tuvo resultados mixtos. Se concluye que las intervenciones basadas en juegos serios son prometedoras para la depresión, aunque la evidencia es todavía muy limitada

R/Bioconductor software for Illumina's Infinium whole-genome genotyping BeadChips

Summary: Illumina produces a number of microarray-based technologies for human genotyping. An Infinium BeadChip is a two-color platform that types between 105 and 106 single nucleotide polymorphisms (SNPs) per sample. Despite being widely used, there is a shortage of open source software to process the raw intensities from this platform into genotype calls. To this end, we have developed the R/Bioconductor package crlmm for analyzing BeadChip data. After careful preprocessing, our software applies the CRLMM algorithm to produce genotype calls, confidence scores and other quality metrics at both the SNP and sample levels. We provide access to the raw summary-level intensity data, allowing users to develop their own methods for genotype calling or copy number analysis if they wish

The interplay between mass, volume, \theta, and <\psibar\psi> in N-flavor QED_2

The Schwinger model (QED_2) with N flavors of massive fermions on a circle of circumference L, or equivalently at finite temperature T, is reduced to a quantum mechanical system of N-1 degrees of freedom. With degenerate fermion masses (m) the chiral condensate develops a cusp singularity at $\theta=\pm \pi$ in the limit L -> $\infty$ or T -> 0, which is removed by a large asymmetry in the fermion masses. Physical quantities sensitively depend on the parameter mL or m/T, and the m -> 0 and L -> $\infty$ (or T -> 0) limits do not commute. A detailed analysis is given for N=3.Comment: LaTeX + 5 figures (4 PS + 1 eepic); uses RevTeX, epsf, eepi