Nurse rock microclimates significantly buffer exposure to freezing T temperature and moderate summer temperature

Nurse tree canopies mitigate exposure to freezing temperatures that could result in injury or mortality to the saguaro cactus (Carnegiea gigantea). Abiotic objects have been hypothesized to provide similar beneficial microclimates. We used data loggers at 11 nurse rock sites to record daily daytime summer maximum and winter nighttime minimum temperatures at Saguaro National Park, Arizona, to examine the effectiveness of rocks to moderate seasonal temperature extremes in the microclimate. Temperatures at rock sites averaged 2 °C warmer than exposed open control sites in winter. We found that the efficiency of rocks to act as insulators significantly increased as temperature at control sites decreased, consistent with studies of tree canopies, and that the insulation effect lasted throughout the night. In summer, rocks reduced exposure to maximum temperatures but did not offer significantly more cooling at higher temperatures. Our results suggest that the protection from freezing temperature offered by rocks in winter is more ecologically beneficial to the saguaro than extreme temperature amelioration during summer in the cold-limited frontiers of the species’ range

Parents’ marital status and child physical abuse potential: the mediation of depression symptoms

Informed by a social interactional framework of stress and parenting, the aim of this study was to examine the mediating effect of depression symptoms on the asso- ciation between parents’ marital status (married and divorced parents) and child physical abuse potential, in a Portuguese community sample. It was hypothesized that the possible observed differences between divorced and married parents in the child physical abuse potential would be explained by their depression symptoms. Parents (N = 892) were assessed in their marital status, severity of depression symptoms and child physical abuse potential. Results showed that, when compared with married parents, divorced parents had higher child physical abuse potential. However, parents’ depression symptomatology was found as a mediator of the effect of marital status differences on child physical abuse potential. The influence of the status of divorced parents on the increase of child physical abuse potential was explained by the increase of the parents’ depression symptoms. This finding suggested that parents’ divorced status had no longer an effect on child physical abuse potential when parents’ depression symptomatology was tested as a mediator vari- able. The present mediation model explained 47 % of the variability in the child physical abuse potential score. Prac- tical implications of these findings for prevention and psy- chological intervention are also discussed.info:eu-repo/semantics/publishedVersio

The Portuguese version of the Psychological Adjustment to Separation Test-Part A (PAST-A): a study with recently and non-recently divorced adults

Past research has demonstrated that divorced adults show more health problems and psychological distress than married adults. Considering the high prevalence rates of divorce among Western countries, new and robust measures should be developed to measure psychological distress after this specific transition in adulthood. The aim of this study was to adapt and validate a Portuguese version of the Psychological Adjustment to Separation Test-Part A (PAST-A; Sweeper and Halford in J Family Psychol 20(4):632–640, 2006). PAST-A is a self-report measure that assesses two key dimensions of separation adjustment problems: lonely-negativity and former partner attachment. Psychometric properties of the Portuguese version of PAST-A were assessed in terms of factor structure, internal consistency, and convergent and divergent validity, in an online convenience sample with divorced adults (N = 460). The PAST-A two-factor structure was confirmed by exploratory and confirmatory factor analyses, with each factor demonstrating very satisfactory internal consistency and good convergence. In terms of discriminant validity, the Portuguese PAST-A reveals a distinct factor from psychological growth after divorce. The results provided support for the use of the Portuguese PAST-A with divorced adults and also suggested that the explicative factors of the psychological adjustment to divorce may be cross-cultural stable. The non-existence of validated divorce-related well-being measures and its implications for divorce research are also discussed

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Nurse rock microclimates significantly buffer exposure to freezing T temperature and moderate summer temperature

Nurse tree canopies mitigate exposure to freezing temperatures that could result in injury or mortality to the saguaro cactus (Carnegiea gigantea). Abiotic objects have been hypothesized to provide similar beneficial microclimates. We used data loggers at 11 nurse rock sites to record daily daytime summer maximum and winter nighttime minimum temperatures at Saguaro National Park, Arizona, to examine the effectiveness of rocks to moderate seasonal temperature extremes in the microclimate. Temperatures at rock sites averaged 2 °C warmer than exposed open control sites in winter. We found that the efficiency of rocks to act as insulators significantly increased as temperature at control sites decreased, consistent with studies of tree canopies, and that the insulation effect lasted throughout the night. In summer, rocks reduced exposure to maximum temperatures but did not offer significantly more cooling at higher temperatures. Our results suggest that the protection from freezing temperature offered by rocks in winter is more ecologically beneficial to the saguaro than extreme temperature amelioration during summer in the cold-limited frontiers of the species’ range

Direct PCR: a new pharmacogenetic approach for the inexpensive testing of HLA-B*57:01

One of the most successful applications of pharmacogenetics research is the genetic screening for HLA-B*57:01, strongly associated with an increased risk to develop hypersensitivity reaction in HIV-positive patients following abacavir administration. Taking into consideration the limits of current genotyping methodologies, we have developed and validated (150 buccal swabs) an inexpensive pharmacogenetic approach for HLA-B*57:01 typing. In our assay DNA extraction and amplification are combined in one single step (direct PCR protocol), which is performed directly on the biological sample without the need of extraction and sequencing passages. The amplicons obtained by direct PCR can be easily separated on the agarose gel under ultraviolet. As per our results, the direct PCR represents a good alternative to the traditional methods of HLA-B*57:01 pharmacogenetic test, especially for those laboratories or countries where currently available approaches are often not available or not affordable. Furthermore it is an innovative approach, promoting a personalized, safer and cost-effective therapy

Spatial mobility, workers and jobs : perspectives from the Northern Ireland experience

Shuttleworth I. and Green A. E. Spatial mobility, workers and jobs: perspectives from the Northern Ireland experience, Regional Studies. How best to address local concentrations of worklessness is a key question for labour market, economic development and social inclusion policy. Historically, initiatives in Northern Ireland have focused on moving 'jobs to workers', but in changed political circumstances there is now greater emphasis on encouraging the movement of 'workers to jobs'. A review of the Northern Ireland experience in the context of broader consideration of the geography and socio-institutional structure of local labour markets sheds light on the difficulties and successes in implementing both approaches. It is concluded that both have a role to play because labour market space is simultaneously 'segmented' and 'seamless'