Bällchen is required for self-renewal of germline stem cells in Drosophila melanogaster

Self-renewing stem cells are pools of undifferentiated cells, which are maintained in cellular niche environments by distinct tissue-specific signalling pathways. In Drosophila melanogaster, female germline stem cells (GSCs) are maintained in a somatic niche of the gonads by BMP signalling. Here we report a novel function of the Drosophila kinase Bällchen (BALL), showing that its cell autonomous role is to maintain the self-renewing capacity of female GSCs independent of BMP signalling. ball mutant GSCs are eliminated from the niche and subsequently differentiate into mature eggs, indicating that BALL is largely dispensable for differentiation. Similar to female GSCs, BALL is required to maintain self-renewal of male GSCs, suggesting a tissue independent requirement of BALL for self-renewal of germline stem cells

The Organic Mindset: Insights from a Mixed Methods Grounded Theory (MM-GT) Study into Organic Food Systems

A broad understanding of food systems includes a complex web of activities, outcomes and drivers, encompassing not only the food and agriculture sectors, but also the social norms and cultures in which those activities are embedded. The organic food and farming movement has lately been portrayed as a food system of its own right, since it contains all necessary sub-systems, consisting of food environments, distribution networks, processing, as well as production and supply, all of which are bounded by an organic guarantee system. The underlying hypothesis of this investigation is that drivers in the organic food system operate on a paradigm level that is associated with the codified principles of ecology, health, fairness and care. Personality science suggests that the choice to act in pro-environmental ways is driven by an internalized sense of obligation or personal norms, which justifies our pursuit of seeking key drivers of food systems in the mindset of the actor. Through integrated findings from actor-centered mixed methods grounded theory research involving eleven case territories, this study identified a pattern of global mindset attributes that intuitively drive organic food system actors toward holistic human and sustainable development

The organic mindset: insights from a mixed methods grounded theory (MM-GT) study into organic food systems

Gefördert durch den Publikationsfonds der Universität Kasse

MOESM1 of TfAP-2 is required for night sleep in Drosophila

Additional file 1. Supplementary information

Rapid Growth of Planktonic Vibrio cholerae Non-O1/Non-O139 Strains in a Large Alkaline Lake in Austria: Dependence on Temperature and Dissolved Organic Carbon Quality▿ †

Vibrio cholerae non-O1/non-O139 strains have caused several cases of ear, wound, and blood infections, including one lethal case of septicemia in Austria, during recent years. All of these cases had a history of local recreational activities in the large eastern Austrian lake Neusiedler See. Thus, a monitoring program was started to investigate the prevalence of V. cholerae strains in the lake over several years. Genetic analyses of isolated strains revealed the presence of a variety of pathogenic genes, but in no case did we detect the cholera toxin gene or the toxin-coregulated pilus gene, both of which are prerequisites for the pathogen to be able to cause cholera. In addition, experiments were performed to elucidate the preferred ecological niche of this pathogen. As size filtration experiments indicated and laboratory microcosms showed, endemic V. cholerae could rapidly grow in a free-living state in natural lake water at growth rates similar to those of the bulk natural bacterial population. Temperature and the quality of dissolved organic carbon had a highly significant influence on V. cholerae growth. Specific growth rates, growth yield, and enzyme activity decreased markedly with increasing concentrations of high-molecular-weight substances, indicating that the humic substances originating from the extensive reed belt in the lake can inhibit V. cholerae growth