A similarity relation for the non-linear energy-transfer in a finite-depth gravity-wave spectrum

The energy transfer in a finite-depth gravity-wave spectrum is investigated in the approximation of a narrow spectrum. It is shown that for ocean depths larger than approximately one tenth of the wavelength (kh [ges ] 0·7) the finite-depth case can be reduced to Longuet-Higgins’ (1976) result for an infinitely deep ocean by a similarity transformation involving changes in scale of the angular spreading function and the transfer rate. For shallower water (kh < 0·7) Longuet-Higgins’ expansion technique is no longer applicable without modification, as the nonlinear coupling coefficient develops a discontinuity at the origin of the expansion. In the range kh [ges ] 0·7 both the magnitude and the two-dimensional frequency-directional distribution of the energy transfer are found not to differ significantly (to within variations by a factor of 2) from the case of an infinitely deep ocean. The transformation rules relating the infinite-depth and finite-depth cases may provide a useful guide for constructing parametrizations of the nonlinear transfer for finite-depth wave prediction models

The horizontal diffusion of tracers by surface waves

The horizontal dispersion of tracers in the presence of a random field of ocean surface waves is examined. Random fluctuations in the local Stokes-drift current cause a water particle to follow a random-walk path. The associated diffusion coefficients for individual particles, particle pairs and a continuous tracer patch can be calculated rigorously within the framework of perturbation analysis. For a fully developed Pierson-Moskowitz wave spectrum all diffusion coefficients scale as the third power of the wind speed and are typically of the order 10−2 m2 s−1 for a wind speed of 10 m s−1. The diffusion coefficients are strongly anisotropic and decrease approximately exponentially with depth below the sea surface

Extraction of mixed layer advection velocities, diffusion coefficients, feedback factors and atmospheric forcing parameters from the statistical analysis of North Pacific SST anomaly fields

The statistical properties of observed North Pacific sea surface temperature (SST) anomalies are simulated by a simple mixed layer advection and diffusion model with stabilizing feedback and local stochastic forcing by the atmosphere. An optimal fit of the model to the SST auto- and cross-spectra yields the effective temperature advection velocities and diffusion coefficients in the mixed layer, the local feedback factors and the strength and scales of the atmospheric forcing. The results obtained by model fitting are in general agreement with independent direct estimates, where such data are available. The analysis supports previous models in which the origin of midlatitude SST anomalies on time scales of months to a few years is attributed to stochastic forcing by the atmosphere

Atmospheric Response to Ice-Age Conditions - Climatology near the Earth's Surface

We present a 6-year simulation of the ice age atmosphere using the T21 Atmospheric General Circulation Model (AGCM) of the European Centre for Medium-Range Weather Forecasts (ECMWF). The lower boundary conditions (18 kyr B.P.) were taken from CLIMAP Project Members (1981). The analysis is restricted to the surface climatology for two reasons: The surface fields are the test data derived from the geological record on land, and they define the upper boundary conditions for simulating the glacial ocean. Model results are shown for the mean annual surface fields of temperature, wind, and precipitation. In the global average the surface temperature was 4.7øC cooler compared to the present temperature. The wind strength increased in mid-latitudes and decreased in tropical trade wind regions. Precipitation did not change significantly in the global average; however, precipitation decreased over land and increased over the ocean. Most of the difference patterns between the present conditions and the ice age climate were statistically significant. The simulated surface climatology is roughly consistent with the paleogeological evidence and with numerical AGCM simulations of other authors. This suggests that presently available AGCMs, including the ECMWF model (T21), are able to describe climates far away from the present, although internal parameteriza- tions were tuned to present data sets

The genetic contribution of the NO system at the glutamatergic post-synapse to schizophrenia : further evidence and meta-analysis

NO is a pleiotropic signaling molecule and has an important role in cognition and emotion. In the brain, NO is produced by neuronal nitric oxide synthase (NOS-I, encoded by NOS1) coupled to the NMDA receptor via PDZ. interactions; this protein-protein interaction is disrupted upon binding of NOS1 adapter protein (encoded by NOS1AP) to NOS-I. As both NOS1 and NOS1AP were associated with schizophrenia, we here investigated these genes in greater detail by genotyping new samples and conducting a meta-analysis of our own and published data. In doing so, we confirmed association of both genes with schizophrenia and found evidence for their interaction in increasing risk towards disease. Our strongest finding was the NOS1 promoter SNP rs41279104, yielding an odds ratio of 1.29 in the meta-analysis. As findings from heterologous cell systems have suggested that the risk allele decreases gene expression, we studied the effect of the variant on NOS1 expression in human post-mortem brain samples and found that the risk allele significantly decreases expression of NOS1 in the prefrontal cortex. Bioinformatic analyses suggest that this might be due the replacement of six transcription factor binding sites by two new binding sites as a consequence of proxy SNPs. Taken together, our data argue that genetic variance in NOS1 resulting in lower prefrontal brain expression of this gene contributes to schizophrenia liability, and that NOS1 interacts with NOS1AP in doing so. The NOS1-NOS1AP PDZ interface may thus well constitute a novel target for small molecules in at least some forms of schizophrenia. PostprintPeer reviewe

On the role of NOS1 ex1f-VNTR in ADHD – allelic, subgroup, and meta-analysis

Attention deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder featuring complex genetics with common and rare variants contributing to disease risk. In a high proportion of cases, ADHD does not remit during adolescence but persists into adulthood. Several studies suggest that NOS1, encoding nitric oxide synthase I, producing the gaseous neurotransmitter NO, is a candidate gene for (adult) ADHD. We here extended our analysis by increasing the original sample, adding two further samples from Norway and Spain, and conducted subgroup and co-morbidity analysis. Our previous finding held true in the extended sample, and also meta-analysis demonstrated an association of NOS1 ex1fVNTR short alleles with adult ADHD (aADHD). Association was restricted to females, as was the case in the discovery sample. Subgroup analysis on the single allele level suggested that the repeat allele caused the association. Regarding subgroups, we found that NOS1 was associated with the hyperactive/impulsive ADHD subtype, but not to pure inattention. In terms of comorbidity, major depression, anxiety disorders, cluster C personality disorders and migraine were associated with short repeats, in particular the repeat allele. Also, short allele carriers had significantly lower IQ. Finally, we again demonstrated an influence of the repeat on gene expression in human post-mortem brain samples. These data validate the role of NOS-I in hyperactive/impulsive phenotypes and call for further studies into the neurobiological underpinnings of this association.PostprintPeer reviewe