Risk of mental ill-health among homeless women in Madrid (Spain)

Several studies have revealed that homeless people suffering from mental health problems are more vulnerable than homeless without those mental health problems. Nevertheless, there is a lack of evidence describing the real circumstances of homeless women. This paper explores the differences between homeless women at high risk of mental ill-health compared with those who do not present this risk. The sample consisted of a group of 120 homeless women in Madrid (Spain). For this study, we collected data on background information (trajectory of homelessness and stressful life events experienced) and current aspects (living conditions, physical health, and social support). The risk of mental ill-health has been measured by the short version of the General Health Questionnaire (GHQ-28). The results showed that homeless women with higher risk of mental ill-health had become homeless at a younger age, had experienced more stressful life events in their lives, had a poorer physical health, felt less happy, had less social support, and a greater feeling of loneliness when compared with homeless women who did not present risk of mental ill-health. Improving knowledge about the risk of mental ill-health among homeless women is essential for the design of specific psychological interventions within this population.Agencia Estatal de Investigación of the Ministerio de Economía, Industria y Competitividad of Spain (Ref. FEM2016-75317-R; Ref. PSI2009- 08472; Ref. FEM2012-35053) and Complutense-Santander Back grant (Ref. CT17/17-CT18/17) to SRMMinisterio de Economía, Industria y CompetitividadUniversidad Complutense de Madri

Role of stressful life events among women experiencing homelessness: An intragroup analysis

The aim of this study is to examine stressful life events (SLEs) among homeless women and how SLEs were related to patterns and trajectories of homelessness. Specifically, the study aimed to replicate and build upon by Muñoz et al. (2005) by using cluster and discriminant analysis in a sample of 116 homeless women. The sample was classified based on SLEs, and the relationship between the resulting subgroups and sociodemographic characteristics, homeless trajectories, physical and mental health, and social support was examined. The results suggest that the three-cluster solution was theoretically and structurally meaningful: (a) the 'Shorter homelessness trajectories and best health and mental health” subgroup was characterized by low levels of SLEs, a shorter homeless trajectory, lower prevalence of physical and mental health problems, and lower rates of alcohol and substances consumption; (b) the 'Early onset of homelessness and poorer health and poorer mental health” subgroup was characterized by a higher prevalence of childhood and adolescence SLEs, an early onset of homelessness and greater chronification, mental health problems, and alcohol consumption; and (c) the 'Chronic homelessness and poorest health and mental health” subgroup was mainly characterized by a higher prevalence of typically adulthood SLEs, as well as some SLEs that may be unique to women, a greater number of periods of homelessness, physical health problems, disabilities, and substance misuse. Increased knowledge about the different subgroups and trajectories of homeless women, as well as their specific characteristics and needs, will help us design social services and policies sensitive to all these differences.Ministerio de Economía, Industria y CompetitividadUniversidad Complutense de MadridAgencia Estatal de Investigación of the Ministerio de Economía, Industria y Competitividad of Spain under Grant FEM2012-35053 and FEM2016-75317-R and Complutense-Santander Back grant (ref: CT17/17-CT18/17) to SRM

In vitro dysbiotic oral biofilms deregulate the host immune response

EUROBIOFILMS 2017 - 5th European Congress on Microbial BiofilmsAn imbalance in the periodontal microbiota and dysbiosis deregulate the host immune response, leading to chronic inflammation. Since little is k nown about the initiation of dysbiosis, it can be hypothesized that some commensal bacteria can suppress the outgrowth of pathobionts by H 2 O 2 production. However, serum and blood components released during inflammation can neutralize this suppressive effec t, leading to the initiation of dysbiosis. The aim of this study is to determine if the neutralizing effect of serum, hemoglobin and hemin on the inhibitory effect of the commensal bacteria on pathobiont growth is translated in a more pronounced immune res ponse. Bacterial quantitative PCR, expression analysis of bacterial virulence and cellular inflammatory genes and cytokine quantification by ELISA were performed to quantify the pathobiont outgrowth and to detect possible differences in inflammatory respon se after exposure of cell cultures to homeostatic or dysbiotic biofilms. Peroxidases, serum and blood components neutralized the inhibitory effect of H 2 O 2 by exogenous peroxidase activity, increasing the pathobiont outgrowth. Moreover, the addition of seru m, peroxidase and blood compounds upregulated the main virulence genes of P. gingivalis and P. intermedia in multi - species biofilms. Exposure of epithelial and fibroblast cultures to these dysbiotic biofilms increased the expression of IL6, IL1β, TNFα and MMP8, but especially of IL8. Moreover, higher amounts of IL8 were produced after the challenge with dysbiotic biofilms. Conversely, homeostatic and commensal biofilms had a minor inflammatory response at expression and protein level. Overall, serum, peroxi dases or blood compounds allowed the outgrowth of pathobionts and increased their virulence. Dysbiotic biofilms enriched in pathobionts and virulence factors significantly increased the inflammatory response compared to homeostatic and commensal biofilmsinfo:eu-repo/semantics/publishedVersio

[S IV] in the NGC 5253 Supernebula: Ionized Gas Kinematics at High Resolution

The nearby dwarf starburst galaxy NGC 5253 hosts a deeply embedded radio-infrared supernebula excited by thousands of O stars. We have observed this source in the 10.5{\mu}m line of S+3 at 3.8 kms-1 spectral and 1.4" spatial resolution, using the high resolution spectrometer TEXES on the IRTF. The line profile cannot be fit well by a single Gaussian. The best simple fit describes the gas with two Gaussians, one near the galactic velocity with FWHM 33.6 km s-1 and another of similiar strength and FWHM 94 km s-1 centered \sim20 km s-1 to the blue. This suggests a model for the supernebula in which gas flows towards us out of the molecular cloud, as in a "blister" or "champagne flow" or in the HII regions modelled by Zhu (2006).Comment: Accepted for publication in the Astrophysical Journal 4 June 201

Locating the Youngest HII Regions in M82 with 7 mm Continuum Maps

We present 7mm Very Large Array continuum images of the starburst galaxy M82. On arcsecond scales, two-thirds of the 7mm continuum consists of free-free emission from HII regions. In the subarcsecond resolution map, we identify 14 compact sources, including 9 bright HII regions with N_Lyc > 10^51 sec^-1. Four of the HII regions have rising spectra, implying emission measures > 10^8 cm^-6 pc. Except for one compact source with peculiar features, all other compact radio sources are found in dust lanes and do not have optical or near-infrared continuum counterparts. Four regions of extended, high brightness (EM > 10^7 cm-6 pc) radio emission are found in our high resolution map, including some as large as ~2", or 30 pc, representing either associations of small HII regions, or sheetlike structures of denser gas. The good correlation between 7 mm emission and Spitzer IRAC 8 micron continuum-removed PAH feature suggests that PAH emission may track the recently formed OB stars. We find an excellent correlation between molecular gas and star formation, particularly dense gas traced by HCN, down to the ~ 45 pc scale in M82. We also find star formation efficiencies (SFEs) of 1-10% on the same scale, based on CO maps. The highest SFE are found in regions with the highest dense gas fractions.Comment: 18 pages, 10 figures. Accepted for publication in A

Programa de integración y mentoría para estudiantes de movilidad nacional e internacional (incoming y outgoing ) en la Facultad de Psicología

Este Proyecto se articula en dos acciones complementarias: a)un programa de mentoría para los estudiantes salientes a otras universidades de destino (outgoing) b)un programa de integración (acogida) para los estudiantes entrantes en la facultad de psicología de la Universidad Complutense de Madrid (incoming) Ambas acciones se apoyan en la mejora de los canales de comunicación, página web y la incorporación de las redes sociales

Heterozygous and Homozygous Variants in SORL1 Gene in Alzheimer's Disease Patients: Clinical, Neuroimaging and Neuropathological Findings

In the last few years, the SORL1 gene has been strongly implicated in the development of Alzheimer’s disease (AD). We performed whole-exome sequencing on 37 patients with early-onset dementia or family history suggestive of autosomal dominant dementia. Data analysis was based on a custom panel that included 46 genes related to AD and dementia. SORL1 variants were present in a high proportion of patients with candidate variants (15%, 3/20). We expand the clinical manifestations associated with the SORL1 gene by reporting detailed clinical and neuroimaging findings of six unrelated patients with AD and SORL1 mutations. We also present for the first time a patient with the homozygous truncating variant c.364C>T (p.R122*) in SORL1, who also had severe cerebral amyloid angiopathy. Furthermore, we report neuropathological findings and immunochemistry assays from one patient with the splicing variant c.4519+5G>A in the SORL1 gene, in which AD was confirmed by neuropathological examination. Our results highlight the heterogeneity of clinical presentation and familial dementia background of SORL1-associated AD and suggest that SORL1 might be contributing to AD development as a risk factor gene rather than as a major autosomal dominant gene.This work was supported by the Instituto de Salud Carlos III (PI17/01067) and AGAUR from the Autonomous Catalan Government (2017SGR1134). Dr. Víctor Antonio Blanco-Palmero is supported by the Instituto de Salud Carlos III (ISCIII, Spanish Biomedical Research Institute) through a “Río Hortega” contract (CM18/0095). Dr. Sara Llamas-Velasco is supported by the Instituto de Salud Carlos III (ISCIII; Spanish Biomedical Research Institute) through a “Juan Rodés” contract (JR 18/00046).S

Famílies botàniques de plantes medicinals

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia, Assignatura: Botànica Farmacèutica, Curs: 2013-2014, Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són els recull de 175 treballs d’una família botànica d’interès medicinal realitzats de manera individual. Els treballs han estat realitzat per la totalitat dels estudiants dels grups M-2 i M-3 de l’assignatura Botànica Farmacèutica durant els mesos d’abril i maig del curs 2013-14. Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pel professor de l’assignatura i revisats i finalment co-avaluats entre els propis estudiants. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality