Primary adenoid cystic carcinoma of the skin: a case report

A 75-year-old male complained of a demarcated plaque on his left upper arm for 13 years. The patient underwent a surgery 7 years prior to the appearance of the palque. Dermatological examination revealed a dark red elevated plaque of 3.0 cm×3.5 cm×0.5 cm in size on the extensor side of the left upper arm. The plaque was firm and mild tenderness, with uniform color and poor mobility. Histology showed that the tumor was composed of myoepithelial and glandular epithelial cells arranged in cribriform and glandular pattern, with glandular and pseudoglandular lumens. Some areas appeared differentiation to sebaceous glands, infiltrative growth pattern and nerve invasion. Immunohistochemistry showed that tumor cells were CK-pan (glandular epithelial+), CK5/6(myoepithelial+), CD117(glandular epithelial+), CK7(glandular epithelial+), EMA(glandular epithelial+), P63(myoepithelial+), Ki-67 (15% positive rate within hotspot area). A diagnosis of primary cutaneous adenoid cystic carcinoma was made. Surgical excision was given, and no recurrence was observed during a 6-month follow-up

Arsenic release : insights into appropriate disposal of arsenic-loaded algae precipitated from arsenic contaminated water

Limited information is available on arsenic (As) release from As-loaded algae precipitated from As contaminated water and its subsequently appropriate disposal. In this study, selected M. aeruginosa as algal model, changes of As concentrations and its speciation were thus investigated in the in-situ treated algae water by optimal coagulation. Meanwhile, after ex-situ disposal, As release kinetics were also examined from its precipitated algae with living and heat-treated conditions. Results showed that in the in-situ treated water, total dissolved As slowly decreased for 6 days, but arsenite increased largely after 3 days partly caused by its reduction status. While being disposed ex-situ, As release from precipitated algae depended not only on intracellular As content but also on the living or heat-treated status of algae. Additionally, potential risks arised from As release in short-term duration (24 h) from both the precipitated algae at 1.0 mu M As(V) pre-exposure with the living and heat-treated conditions due to their higher release. Furthermore, As release in long-term (6 d) duration from heat-treated algae at 10.0 mu M As(V) pre-exposure also resulted in potential risks. Accordingly, this study offers insights into the appropriate methods at a proper time of disposing precipitated algae with As-contamination