Lifestyle factors and ovarian cancer outcomes

Purpose: Few studies have reported on the lifestyle characteristics of ovarian cancer survivors. The objectives of this study were to characterize the associations between physical activity (PA) and body size (BS) with health-related quality of life (HRQOL) and ovarian cancer recurrence in a sample of regional and distal stage ovarian cancer survivors. Methods: Epithelial ovarian cancer survivors in their first clinical remission, with no evidence of recurrent disease were identified from The University of Texas MD Anderson Cancer Center tumor registry. A total of 51 survivors consented to participate in a battery of self-reported questionnaires. Trained staff collected data on anthropometric and recurrence data were collected from the tumor registry. Generalized linear models were used to assess the relationship between PA, BS, and HRQOL. Cox proportional hazard models were used to assess the associations between PA, BS, and recurrence-free survival. Results: Most (59%) women were overweight or obese (BMI \u3c 25 kg/m2) , 49% met current guidelines for PA (150 minutes of moderate to vigorous PA/week), and 29% displayed characteristics of abdominal obesity (\u3e88 centimeters). Women who were not obese reported significantly higher (better) overall HRQOL (point difference = 10.8, P \u3c 0.05) and mental health (point difference = 12.4, P \u3c 0.05) scores than women who were obese. Elevated waist circumference and physical activity were not significantly associated with HRQOL outcomes and we did not find any associations between lifestyle behaviors and recurrence free survival (all P \u3e 0.05). Conclusions: Ovarian cancer survivors with characteristics of overall and abdominal obesity may be at risk for deficits in HRQOL and could benefit from interventions designed to reduce weight. More research is needed to determine whether meeting guidelines for physical activity is associated with improvements in health outcomes this population

More three-point correlators of giant magnons with finite size

In the framework of the semiclassical approach, we compute the normalized structure constants in three-point correlation functions, when two of the vertex operators correspond to heavy string states, while the third vertex corresponds to a light state. This is done for the case when the heavy string states are finite-size giant magnons with one or two angular momenta, and for two different choices of the light state, corresponding to dilaton operator and primary scalar operator. The relevant operators in the dual gauge theory are Tr(F_{\mu\nu}^2 Z^j+...) and Tr(Z^j). We first consider the case of AdS_5 x S^5 and N = 4 super Yang-Mills. Then we extend the obtained results to the gamma-deformed AdS_5 x S^5_\gamma, dual to N = 1 super Yang-Mills theory, arising as an exactly marginal deformation of N = 4 super Yang-Mills.Comment: 14 pages, no figure

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid

Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment with the antioxidant alpha-lipoic acid (LA). Methods: Cultured ONH astrocytes were treated with 1.0 ng/ml TGF-beta(2) for 24 h or 200 mu M hydrogen peroxide (H2O2) for 1 h. Lipid peroxidation was measured by a decrease in cis-pari-naric acid fluorescence. Additionally, cells were pretreated with different concentrations of LA before TGF-beta 2 or H2O2 exposure. Expressions of the heat shock protein (Hsp) alpha B-crystallin and Hsp27, the extracellular matrix (ECM) component fibronectin and the ECM-modulating protein connective tissue growth factor (CTGF) were examined with immunohistochemistry and real-time PCR analysis. Results: Both TGF-beta(2) and H2O2 increased lipid peroxidation. Treatment of astrocytes with TGF-beta(2) and H2O2 upregulated the expression of alpha B-crystallin, Hsp27, fibronectin and CTGF. Pretreatment with different concentrations of LA reduced the TGF-beta(2)- and H2O2-stimulated gene expressions. Conclusion: We showed that TGF-beta(2)- and H2O2-stimulated gene expressions could be prevented by pretreatment with the antioxidant LA in cultured human ONH astrocytes. Therefore, it is tempting to speculate that the use of antioxidants could have protective effects in glaucomatous optic neuropathy. Copyright (C) 2012 S. Karger AG, Base

Holographic three-point functions for short operators

We consider holographic three-point functions for operators dual to short string states at strong coupling in N=4 super Yang-Mills. We treat the states as point-like as they come in from the boundary but as strings in the interaction region in the bulk. The interaction position is determined by saddle point, which is equivalent to conservation of the canonical momentum for the interacting particles, and leads to conservation of their conformal charges. We further show that for large dimensions the rms size of the interaction region is small compared to the radius of curvature of the AdS space, but still large compared to the string Compton wave-length. Hence, one can approximate the string vertex operators as flat-space vertex operators with a definite momentum, which depends on the conformal and R-charges of the operator. We then argue that the string vertex operator dual to a primary operator is chosen by satisfying a twisted version of Q^L=Q^R, up to spurious terms. This leads to a unique choice for a scalar vertex operator with the appropriate charges at the first massive level. We then comment on some features of the corresponding three-point functions, including the application of these results to Konishi operators.Comment: 24 pages; v2: References added, typos fixed, minor change

On the effect of resonances in composite Higgs phenomenology

We consider a generic composite Higgs model based on the coset SO(5)/SO(4) and study its phenomenology beyond the leading low-energy effective lagrangian approximation. Our basic goal is to introduce in a controllable and simple way the lowest-lying, possibly narrow, resonances that may exist is such models. We do so by proposing a criterion that we call partial UV completion. We characterize the simplest cases, corresponding respectively to a scalar in either singlet or tensor representation of SO(4) and to vectors in the adjoint of SO(4). We study the impact of these resonances on the signals associated to high-energy vector boson scattering, pointing out for each resonance the characteristic patterns of depletion and enhancement with respect to the leading-order chiral lagrangian. En route we derive the O(p^4) general chiral lagrangian and discuss its peculiar accidental and approximate symmetries.Comment: v3: a few typos corrected. Conclusions unchange

Wave functions and correlation functions for GKP strings from integrability

We develop a general method of computing the contribution of the vertex operators to the semi-classical correlation functions of heavy string states, based on the state-operator correspondence and the integrable structure of the system. Our method requires only the knowledge of the local behavior of the saddle point configuration around each vertex insertion point and can be applied to cases where the precise forms of the vertex operators are not known. As an important application, we compute the contributions of the vertex operators to the three-point functions of the large spin limit of the Gubser-Klebanov-Polyakov (GKP) strings in $AdS_3$ spacetime, left unevaluated in our previous work [arXiv:1110.3949] which initiated such a study. Combining with the finite part of the action already computed previously and with the newly evaluated divergent part of the action, we obtain finite three-point functions with the expected dependence of the target space boundary coordinates on the dilatation charge and the spin.Comment: 80 pages, 7 figures, v2: typos and minor errors corrected, a reference added, v3: typos and a reference corrected, published versio

Correlation functions of three heavy operators - the AdS contribution

We consider operators in N=4 SYM theory which are dual, at strong coupling, to classical strings rotating in S^5. Three point correlation functions of such operators factorize into a universal contribution coming from the AdS part of the string sigma model and a state-dependent S^5 contribution. Consequently a similar factorization arises for the OPE coefficients. In this paper we evaluate the AdS universal factor of the OPE coefficients which is explicitly expressed just in terms of the anomalous dimensions of the three operators.Comment: 49 pages, 3 figures; v.2 references corrected; v3: corrected discussion in section 5, results unchange

NLO QCD Corrections to BcB_c-to-Charmonium Form Factors

The $B_c(^1S_0)$ meson to S-wave Charmonia transition form factors are calculated in next-to-leading order(NLO) accuracy of Quantum Chromodynamics(QCD). Our results indicate that the higher order corrections to these form factors are remarkable, and hence are important to the phenomenological study of the corresponding processes. For the convenience of comparison and use, the relevant expressions in asymptotic form at the limit of $m_c\rightarrow0$ for the radiative corrections are presented

Three-point correlators for giant magnons

Three-point correlation functions in the strong-coupling regime of the AdS/CFT correspondence can be analyzed within a semiclassical approximation when two of the vertex operators correspond to heavy string states having large quantum numbers while the third vertex corresponds to a light state with fixed charges. We consider the case where the heavy string states are chosen to be giant magnon solitons with either a single or two different angular momenta, for various different choices of light string states.Comment: 15 pages. Latex. v2: Misprints corrected. Published versio

Holographic 3-point function at one loop

We explore the recent weak/strong coupling match of three-point functions in the AdS/CFT correspondence for two semi-classical operators and one light chiral primary operator found by Escobedo et al. This match is between the tree-level three-point function with the two semi-classical operators described by coherent states while on the string side the three-point function is found in the Frolov-Tseytlin limit. We compute the one-loop correction to the three-point function on the gauge theory side and compare this to the corresponding correction on the string theory side. We find that the corrections do not match. Finally, we discuss the possibility of further contributions on the gauge theory side that can alter our results.Comment: 24 pages, 2 figures. v2: Typos fixed, Ref. added, figure improved. v3: Several typos and misprints fixed, Ref. updated, figures improved, new section 2.3 added on correction from spin-flipped coherent state, computations on string theory side improve