Team collaboration capabilities as a factor in startup success

[EN] This paper discusses the role of team collaboration as a building block for cultivating capabilities in technology-based startups. This conceptual framework draws on a literature review of innovation and entrepreneurship research to understand the intra-organization collaboration mechanisms among team members in technology-based startups. Introducing the concept of team collaboration capabilities represents a new approach to understanding the interaction conditions that give rise to new capabilities from a venture team as its organizational base. Rapid new capability building represents a competitive advantage in environments characterized by innovative technological change, known as dynamic capabilities.We are grateful to the Consejo Nacional de Ciencia y Tecnología de México (CONACyT) for funding Anna Karina Lopez-Hernandez s Ph.D. research grant. We also thank the Conselleria d Educació, Investigació,Cultura i Esport (GV/2018/003) for financial support for this research. We are indebted to Pablo D Este for his detailed and insightful feedbackLopez-Hernandez, AK.; Fernandez-Mesa, A.; Edwards-Schachter, M. (2018). Team collaboration capabilities as a factor in startup success. Journal of Technology Management & Innovation. 13(4):13-22. http://hdl.handle.net/10251/154377S132213

Factores de riesgo maternos asociados al bajo peso al nacer en San Juan y Martínez

Introduction: Low birth weight (LBW) is considered to be any newborn baby weighing less than 2500g at the time of delivery, whatever the cause and regardless of the length of gestation.Objectives: to identify maternal risk factors associated with low birth weight.Methods: a descriptive, prospective, longitudinal study was conducted on 31 mothers whose product of conception was low birth weight in San Juan y Martinez municipality during the period 2018-2019. A survey was applied to identify the main risk factors that contributed to this incidence.Results: the most representative age group was 21-35 with 74%, there was an inadequate weight gain for the 42 % of them, there was a predominance of nulliparity for 64% of adolescents, pregnancy-related diseases were present in 88%, and pre-existing conditions in the 84% of mothers during pregnancy; 82% did not plan the pregnancy.Conclusions: the most influential risk factors were inadequate weight gain during pregnancy with adequate initial weight, nulliparity, pregnancy-related diseases such as vaginal infections, high blood pressure, anemia during pregnancy, pretermIntroducción: se considera bajo peso al nacer a todo recién nacido que al momento del parto tenga un peso inferior a los 2500g, cualquiera que sea la causa y sin tener en cuenta la duración de la gestación.Objetivos: identificar los factores de riesgo maternos asociados con el bajo peso al nacer. Métodos: se realizó una investigación descriptiva, longitudinal prospectiva, a las 31 madres cuyo producto de la concepción fue bajo peso, en el municipio San Juan y Martínez, en el período comprendido de 2018-2019, a las cuales se les aplicó una encuesta para identificar los principales factores de riesgo que contribuyeron en su incidencia.Resultados: el grupo de edad más representativo fue el de 21-35 con el 74 %, hubo una inadecuada ganancia de peso para un 42 %, con un predominio de la nuliparidad para un 64 %, mayor en las adolescentes. Las afecciones asociadas al embarazo estuvieron presentes en un 88 % y las enfermedades propias del embarazo en un 84 % de las madres durante la gestación. El 82 % no tuvo planificación de su embarazo.Conclusiones: los factores de riesgos más influyentes constituyeron: la ganancia inadecuada de peso durante la gestación con peso inicial adecuado, la nuliparidad, las afecciones asociadas al embarazo como: la infección vaginal, hipertensión arterial, anemia durante el embarazo, el parto pretérmino, la no planificación del embarazo y la no utilización del ácido fólico en tiempo preconcepcional

Factores de riesgo maternos asociados al bajo peso al nacer en San Juan y Martínez

Introduction: Low birth weight (LBW) is considered to be any newborn baby weighing less than 2500g at the time of delivery, whatever the cause and regardless of the length of gestation.Objectives: to identify maternal risk factors associated with low birth weight.Methods: a descriptive, prospective, longitudinal study was conducted on 31 mothers whose product of conception was low birth weight in San Juan y Martinez municipality during the period 2018-2019. A survey was applied to identify the main risk factors that contributed to this incidence.Results: the most representative age group was 21-35 with 74%, there was an inadequate weight gain for the 42 % of them, there was a predominance of nulliparity for 64% of adolescents, pregnancy-related diseases were present in 88%, and pre-existing conditions in the 84% of mothers during pregnancy; 82% did not plan the pregnancy.Conclusions: the most influential risk factors were inadequate weight gain during pregnancy with adequate initial weight, nulliparity, pregnancy-related diseases such as vaginal infections, high blood pressure, anemia during pregnancy, pretermIntroducción: se considera bajo peso al nacer a todo recién nacido que al momento del parto tenga un peso inferior a los 2500g, cualquiera que sea la causa y sin tener en cuenta la duración de la gestación.Objetivos: identificar los factores de riesgo maternos asociados con el bajo peso al nacer. Métodos: se realizó una investigación descriptiva, longitudinal prospectiva, a las 31 madres cuyo producto de la concepción fue bajo peso, en el municipio San Juan y Martínez, en el período comprendido de 2018-2019, a las cuales se les aplicó una encuesta para identificar los principales factores de riesgo que contribuyeron en su incidencia.Resultados: el grupo de edad más representativo fue el de 21-35 con el 74 %, hubo una inadecuada ganancia de peso para un 42 %, con un predominio de la nuliparidad para un 64 %, mayor en las adolescentes. Las afecciones asociadas al embarazo estuvieron presentes en un 88 % y las enfermedades propias del embarazo en un 84 % de las madres durante la gestación. El 82 % no tuvo planificación de su embarazo.Conclusiones: los factores de riesgos más influyentes constituyeron: la ganancia inadecuada de peso durante la gestación con peso inicial adecuado, la nuliparidad, las afecciones asociadas al embarazo como: la infección vaginal, hipertensión arterial, anemia durante el embarazo, el parto pretérmino, la no planificación del embarazo y la no utilización del ácido fólico en tiempo preconcepcional

Comportamiento de las genodermatosis en el municipio de San Juan y Martínez

Introduction: genetic diseases and congenital defects constitute the second cause of death only in the child of one year; these diseases can be of chromosomal, multifactorial and monogenetic origin. Genodermatoses are included in the last one, where the early diagnosis influences on the prognosis of life of the genetic carrier.Objective: to characterize the behavior of genodermatoses in San Juan y Martinez municipality in the period 2018-2019.Methods: a descriptive, cross-sectional research was conducted, with a target group comprising 476 patients with genetic diseases and a sample of 40 patients with genodermatoses; working with the variables of age, sex, color of skin, family history, type of genodermatosis and type of hereditary patterns, through the collection of data for the review of clinical histories.    Results: it was recorded that 83,3 % belonged to male sex, white skin color prevailed (78 %), 29 patients had no family history, ichthyosis (27,5 %) predominated, and autosomal dominant hereditary pattern was the most frequent (70 %). Conclusions: genetic diseases are gaining a greater position in society every day, as a result preventive actions must be taken, starting from the Primary Health Care in order to counteract its incidence and improve the quality of life of the patients. Introducción: las enfermedades genéticas y defectos congénitos constituyen la segunda causa de muerte en menores de un año, conociendo que estas enfermedades pueden ser de origen cromosómico, multifactorial y monogénicas. En esta última se incluyen las genodermatosis, donde el diagnóstico precoz influye en el pronóstico de vida del paciente que la contrae.Objetivo: caracterizar el comportamiento de las genodermatosis en el municipio de San Juan y Martínez en el período 2018-2019.Métodos: se realizó una investigación descriptiva y transversal, con un universo de 476 pacientes con enfermedades genéticas y una muestra de 40 pacientes con genodermatosis. Se trabajó con las variables: edad, sexo, color de la piel, antecedentes familiares, tipo de genodermatosis y tipo de patrones de herencia, mediante la obtención de datos por la revisión de historias clínicas.Resultados: se obtuvo que el 83,3 % pertenecían al sexo masculino, predominó el color de la piel blanca con un 78 %, 29 pacientes no tuvieron antecedentes patológicos familiares, predominaron las ictiosis con un 27,5 %, y el patrón de herencia más frecuente fue el autosómico dominante con un 70 %.Conclusiones: las enfermedades genéticas cada día ganan un lugar mayor en la sociedad, por lo que se deben intensificar las acciones preventivas desde la atención primaria de salud, para así contrarrestar su incidencia y mejorar la calidad de vida de los pacientes

Comportamiento de las genodermatosis en el municipio de San Juan y Martínez

Introduction: genetic diseases and congenital defects constitute the second cause of death only in the child of one year; these diseases can be of chromosomal, multifactorial and monogenetic origin. Genodermatoses are included in the last one, where the early diagnosis influences on the prognosis of life of the genetic carrier.Objective: to characterize the behavior of genodermatoses in San Juan y Martinez municipality in the period 2018-2019.Methods: a descriptive, cross-sectional research was conducted, with a target group comprising 476 patients with genetic diseases and a sample of 40 patients with genodermatoses; working with the variables of age, sex, color of skin, family history, type of genodermatosis and type of hereditary patterns, through the collection of data for the review of clinical histories.    Results: it was recorded that 83,3 % belonged to male sex, white skin color prevailed (78 %), 29 patients had no family history, ichthyosis (27,5 %) predominated, and autosomal dominant hereditary pattern was the most frequent (70 %). Conclusions: genetic diseases are gaining a greater position in society every day, as a result preventive actions must be taken, starting from the Primary Health Care in order to counteract its incidence and improve the quality of life of the patients. Introducción: las enfermedades genéticas y defectos congénitos constituyen la segunda causa de muerte en menores de un año, conociendo que estas enfermedades pueden ser de origen cromosómico, multifactorial y monogénicas. En esta última se incluyen las genodermatosis, donde el diagnóstico precoz influye en el pronóstico de vida del paciente que la contrae.Objetivo: caracterizar el comportamiento de las genodermatosis en el municipio de San Juan y Martínez en el período 2018-2019.Métodos: se realizó una investigación descriptiva y transversal, con un universo de 476 pacientes con enfermedades genéticas y una muestra de 40 pacientes con genodermatosis. Se trabajó con las variables: edad, sexo, color de la piel, antecedentes familiares, tipo de genodermatosis y tipo de patrones de herencia, mediante la obtención de datos por la revisión de historias clínicas.Resultados: se obtuvo que el 83,3 % pertenecían al sexo masculino, predominó el color de la piel blanca con un 78 %, 29 pacientes no tuvieron antecedentes patológicos familiares, predominaron las ictiosis con un 27,5 %, y el patrón de herencia más frecuente fue el autosómico dominante con un 70 %.Conclusiones: las enfermedades genéticas cada día ganan un lugar mayor en la sociedad, por lo que se deben intensificar las acciones preventivas desde la atención primaria de salud, para así contrarrestar su incidencia y mejorar la calidad de vida de los pacientes

Post-synthetic ligand exchange as a route to improve the affinity of ZIF-67 towards CO2

The Zeolitic Imidazolate Framework 67 (ZIF-67) is a highly promising material owing to its exceptional thermal stability, large specific surface area, costeffectiveness, and versatile applications. One of the potential applications of ZIF-67 is gas separation processes, among which the separation of CO2/CH4 mixtures has attracted great interest nowadays in the biogas sector. However, when it comes to CO2/CH4 separation, ZIF-67 falls short as it lacks the desired selectivity despite its high adsorption capacity. This limitation arises from its relatively low affinity towards CO2. In this study, we have addressed this issue by partially exchanging the ligand of ZIF-67, specifically replacing 2-methylimidazole with 1,2,4 (1H) triazole, which introduces an additional nitrogen atom. This modification resulted in ZIF-67 showing significantly enhanced affinity towards CO2 and, as a result, greater selectivity towards CO2 over CH4. The modified materials underwent thorough characterization using various techniques, and their adsorption capacity was evaluated through high-pressure adsorption isotherms. Furthermore, their separation performance was assessed using the Ideal Solution Adsorption Theory, which provided valuable insights into their potential for efficient gas separation

Dabrafenib plus trametinib for compassionate use in metastatic melanoma: A STROBE-compliant retrospective observational postauthorization study

The main objective of the study was to evaluate the efficacy and safety of dabrafenib alone or combined with trametinib for compassionate use in patients with metastatic melanoma.This retrospective, observational study involved 135 patients with unresectable stage IIIC or stage IV melanoma from an expanded-access program at 30 Spanish centers.Forty-eight patients received dabrafenib monotherapy and 87 received combination dabrafenib and trametinib; 4.4% and 95.6% of the patients had stage IIIC and IV melanoma, respectively. All patients showed BRAF mutations in their primary or metastatic lesions; 3 were positive for V600K while the remainder had V600E or V600+. A positive response to treatment was reported in 89.3% of the patients. Overall survival rates at 12 and 24 months were 59.6% (95% confidence interval [CI], 52.5-68.9%) and 36.4% (95% CI, 27.8-45%), respectively. Progression-free survival rates at 12 and 24 months were 39.3% (95% CI, 31.1-47.5%) and 21.6% (95% CI, 14.5-28.7%), respectively. Fifty-seven patients (42.2%) reported cutaneous toxicity of any type, mainly hyperkeratosis (14.8%) and rash (11.9%). The most frequent adverse events were pyrexia (27.4%), asthenia (19.3%), arthralgia (16.9%), and diarrhoea (13.2%).Our results suggest that both dabrafenib alone or in combination with trametinib are effective for compassionate use in terms of response and/or survival rates. However, differences in patients' prognostic features ought to be considered. No new findings were revealed regarding the safety profiles of either regimen. This is the first study to evaluate the efficacy of these 2 selective BRAF and mitogen-activated extracellular signal-regulated kinase inhibitors in a real-world setting in Spain

Geodivulgar: Geología y Sociedad

Depto. de Geodinámica, Estratigrafía y PaleontologíaDepto. de Química InorgánicaDepto. de Didáctica de las Ciencias Experimentales , Sociales y MatemáticasFac. de Ciencias GeológicasFac. de Ciencias QuímicasFac. de EducaciónFALSEsubmitte

Geodivulgar: Geología y Sociedad

Memoria final del Proyecto Innova Docencia 2023-23 nº 58. GEODIVULGAR: Geología y SociedadUCMDepto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasFALSEsubmitte

Hepatic microcirculation and mechanisms of portal hypertension.

The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells (LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in liver homeostasis, including in preserving hepatocyte function, regulating the vascular tone and controlling inflammation. Liver microcirculatory dysfunction is one of the key mechanisms that promotes the progression of chronic liver disease (also termed cirrhosis) and the development of its major clinical complication, portal hypertension. In the present Review, we describe the current knowledge of liver microcirculatory dysfunction in cirrhotic portal hypertension and appraise the preclinical models used to study the liver circulation. We also provide a comprehensive summary of the promising therapeutic options to target the liver microvasculature in cirrhosis