Shipibo Hunting And The Overkill Hypothesis

The overkill hypothesis, as promulgated by Paul Martin and others, is supported by evidence of asynchronous extinction of megafauna and other species in North America associated with the arrival of Pleistocene hunters in the Western Hemisphere. In this essay, further evidence—based on observations made of the response of a small party of Shipibo hunters in the upper Peruvian Amazon—is offered in support of the hypothesis. These observations were made during an exploratory tripinto the headwaters of a remote Amazonian tributary, a pristine area not occupied by human beings that was plentiful with wildlife. The Shipibo aggressively took the opportunity to catch and kill game, mostly fish, well beyond the immediate nutritional needs of the group. Whereas this response is highly adaptive in the condition of protein scarcity and community sharing, it illustrated the effectiveness and efficiency of Shipibo hunting skills as a pure response to the unexpected availability of easily caught game. Though limited in scope, the data appear to support the overkill hypothesis. La hipótesis de sobrematar, promulgada por Paul Martin y otros, es apoyada por la evidencia de la extinción asincrónica de la megafauna y otras especies en América del Norte asociada con la llegada de cazadores del Pleistoceno en el hemisferio occidental. En este ensayo presentamos observaciones sobre la respuesta de un grupo pequeño de cazadores Shipibo en el alto Amazonas Peruano durante un viaje exploratorio hasta la cabecera de un río remoto, tributario del Amazonas. Estas observaciones sostienen la hipótesis de sobrematar. Cuando los Shipibo encontraron una zona prístina, no explorada, no ocupada por seres humanos y con mucha vida silvestre, ellos aprovecharon agresivamente la oportunidad de caputrar y matar animales, principalmente pescado, en cantidades que sobrepasaban las necesidades nutricionales del grupo. Aunque esta respuesta es altamente adaptativa en condiciones de escasez de proteínas o en comunidades que practican el compartimiento comunal, quedó demostrada la efectividad y eficiencia de las capacidades cazadoras de los Shipibo como respuesta a la disponibilidad no esperada de recursos fácilmente obenidos y ayuda a apoyar la hipótesis de sobrematar

Coordinate Singularities in Harmonically-sliced Cosmologies

Harmonic slicing has in recent years become a standard way of prescribing the lapse function in numerical simulations of general relativity. However, as was first noticed by Alcubierre (1997), numerical solutions generated using this slicing condition can show pathological behaviour. In this paper, analytic and numerical methods are used to examine harmonic slicings of Kasner and Gowdy cosmological spacetimes. It is shown that in general the slicings are prevented from covering the whole of the spacetimes by the appearance of coordinate singularities. As well as limiting the maximum running times of numerical simulations, the coordinate singularities can lead to features being produced in numerically evolved solutions which must be distinguished from genuine physical effects.Comment: 21 pages, REVTeX, 5 figure

Extremal Graph Theory for Metric Dimension and Diameter

A set of vertices $S$ \emph{resolves} a connected graph $G$ if every vertex is uniquely determined by its vector of distances to the vertices in $S$. The \emph{metric dimension} of $G$ is the minimum cardinality of a resolving set of $G$. Let $\mathcal{G}_{\beta,D}$ be the set of graphs with metric dimension $\beta$ and diameter $D$. It is well-known that the minimum order of a graph in $\mathcal{G}_{\beta,D}$ is exactly $\beta+D$. The first contribution of this paper is to characterise the graphs in $\mathcal{G}_{\beta,D}$ with order $\beta+D$ for all values of $\beta$ and $D$. Such a characterisation was previously only known for $D\leq2$ or $\beta\leq1$. The second contribution is to determine the maximum order of a graph in $\mathcal{G}_{\beta,D}$ for all values of $D$ and $\beta$. Only a weak upper bound was previously known

New explicit spike solution -- non-local component of the generalized Mixmaster attractor

By applying a standard solution-generating transformation to an arbitrary vacuum Bianchi type II solution, one generates a new solution with spikes commonly observed in numerical simulations. It is conjectured that the spike solution is part of the generalized Mixmaster attractor.Comment: Significantly revised. Colour figures simplified to accommodate non-colour printin

A randomised trial evaluating Bevacizumab as adjuvant therapy following resection of AJCC stage IIB, IIC and III cutaneous melanoma : an update

At present, there are no standard therapies for the adjuvant treatment of malignant melanoma. Patients with primary tumours with a high-Breslow thickness (stages IIB and IIC) or with resected loco-regional nodal disease (stage III) are at high risk of developing metastasis and subsequent disease-related death. Given this, it is important that novel therapies are investigated in the adjuvant melanoma setting. Since angiogenesis is essential for primary tumour growth and the development of metastasis, anti-angiogenic agents are attractive potential therapeutic candidates for clinical trials in the adjuvant setting. Therefore, we initiated a phase II trial in resected high-risk cutaneous melanoma, assessing the efficacy of bevacizumab versus observation. In the interim safety data analysis, we demonstrate that bevacizumab is a safe therapy in the adjuvant melanoma setting with no apparent increase in the surgical complication rate after either primary tumour resection and/or loco-regional lymphadenectomy

An unsymmetric ligand framework for noncoupled homo- and heterobimetallic complexes

We introduce a new unsymmetric ligand, PDIpCy (PDI = pyridyldiimine; Cy = cyclam), that offers two distinct, noncoupled coordination sites. A series of homo- and heterobimetallic complexes, [Zn2(PDIpCy)(THF)(OTf)4] (1; THF = tetrahydrofuran and OTf = triflate), [Ni2(PDIpCy)(THF)(OTf)2](OTf)2 (2), and [NiZn(PDIpCy)(THF)(OTf)4] (3), are described. The one-electron-reduced compounds, [Zn2(PDIpCy)(OTF)3] (4), [Ni2(PDIpCy)(OTf)](OTf)2 (5), and [NiZn(PDIpCy)(OTf)3] (6), were isolated, and their electronic structures were characterized. The reduced compounds are charge-separated species, with electron storage at either the PDI ligand (4) or at the PDI-bound metal ion (5 and 6)

Femtochemistry of mass-selected negative-ion clusters of dioxygen: Charge-transfer and solvation dynamics

Femtosecond, time-resolved photoelectron spectroscopy is used to investigate the dissociation dynamics of mass-selected anionic molecular-oxygen clusters. The observed transient photoelectron signal for the clusters (O_2)^−_n  (n = 3–5) shows the O^−_2 production; for n = 1 and 2, we observe no time-dependence at this wavelength of 800 nm. The observed transients are bi-exponential in form with two distinct time constants, but with clear trends, for all investigated cluster sizes. These striking observations describe the reaction pathways of the solvated core and we elucidate two primary processes: Charge transfer with concomitant nuclear motion, and direct dissociation of the O^−_4 core-ion via electron recombination; the former takes 700–2700 fs, while the latter is on a shorter time scale, 110–420 fs. Both rates decrease differently upon increasing cluster size, indicating the critical role of step-wise solvation