500 research outputs found

    Nonequilibrium Thermodynamics of Cell Signaling

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    The need to provide professional development in tourism to students who minor in public relations of the B.A. in Modern Languages with Specialization in French and English, at the Department of Foreign Languages, University of el Salvador, 2019 /

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    This research Project has as main objective to investigate the need to provide professional development in tourism to students who minor in Public Relations of the B.A. in Modern Languages with specialization in French and English, at the Department of Foreign Languages, University of El Salvador. First, it is presented an overview of tourism history in El Salvador and how it has been experiencing many changes since the Golden Era, (through) the Peace Agreements in 1992, until the improvement it has had until now. Moreover, the research team highlights how tourism has been growing in the last 10 years, and its importance for Salvadoran economy. Then, there is a review of the educational aims of the B.A. in Modern Languages and the process for updating the current Public Relations curriculum. Part of the research include to analyze the importance of updating the curriculum for the Public Relations area of the Modern Languages Major based on the needs of current labor market in the country. Afterwards, the results of the investigation are presented. It is essential to show the interest of Modern Languages students and also graduates of this major, in studying a specialization in tourism, in order to acquire extra knowledge besides being polyglot, not only to improve their skills, but also to get better job opportunities in the current market labor in the country and outside the country. Finally, some recommendations are proposed to professors that must keep updating the syllabus content, to students to be proactive and self-taught and also to authorities to offer to offer different graduation process like pre-specializations

    Non-Equilibrium Hyperbolic Transport in Transcriptional Regulation

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    In this work we studied memory and irreversible transport phenomena in a non-equilibrium thermodynamical model for genomic transcriptional regulation. Transcriptional regulation possess an extremely complex phenomenology, and it is, of course, of foremost importance in organismal cell development and in the pathogenesis of complex diseases. A better understanding of the way in which these processes occur is mandatory to optimize the construction of gene regulatory networks, but also to connect these networks with multi-scale phenomena (e.g. metabolism, signalling pathways, etc.) under an integrative Systems Biology-like vision. In this paper we analyzed three simple mechanisms of genetic stimulation: an instant pulse, a periodic biochemical signal and a saturation process with sigmoidal kinetics and from these we derived the system's thermodynamical response, in the form of, for example, anomalous transcriptional bursts

    Functional impact of multi-omic interactions in breast cancer subtypes

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    Multi-omic approaches are expected to deliver a broader molecular view of cancer. However, the promised mechanistic explanations have not quite settled yet. Here, we propose a theoretical and computational analysis framework to semi-automatically produce network models of the regulatory constraints influencing a biological function. This way, we identified functions significantly enriched on the analyzed omics and described associated features, for each of the four breast cancer molecular subtypes. For instance, we identified functions sustaining over-representation of invasion-related processes in the basal subtype and DNA modification processes in the normal tissue. We found limited overlap on the omics-associated functions between subtypes; however, a startling feature intersection within subtype functions also emerged. The examples presented highlight new, potentially regulatory features, with sound biological reasons to expect a connection with the functions. Multi-omic regulatory networks thus constitute reliable models of the way omics are connected, demonstrating a capability for systematic generation of mechanistic hypothesis

    DEMOCRACIA, SOCIEDAD CIVIL Y ESPACIO PÚBLICO: UN ANÁLISIS SOBRE MÉXICO CON BASE EN LA PERSPECTIVA DE ANTONIO GRAMSCI Y JÜRGEN HABERMAS

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    En esta tesis se habla de la sociedad civil como espacio de deliberación y de convergencia entre corrientes de pensamiento distintas. Esta perspectiva se desarrolla a la luz de las teorías elaboradas por Antonio Gramsci y Jurgen Habermas, a ellas se les conoce como el neoiluminismo, dicha corriente destaca a la democracia no sólo desde el punto de vista institucional sino sobre todo, cultural y social
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