Comportamiento asintótico del rendimiento sobre el capital y de la razón precio-utilidad

The cost of capital is an indicator of the profitability of a company. Very often, this indicator in conjunction with the return on equity (ROE) is utilized in analyzing investment projects. Many studies have shown that the cost of capital tends to a long-term value, which reveals a mean reversion dynamics. This research examines the behavior of the return on capital by means of Vasicek model. Moreover, under certain conditions, the capital cost is estimated through the model Vasicek. Finally, shows that the return on equity and the inverse of the multiple price-book value are consistent with dynamics presenting mean reversion.Decisiones de inversión, múltiplos financieros, utilidades anormales

Plan de negocio Play Tejo

92 Páginas.Play Tejo es la versión de un bar, restaurante y lugar de reuniones sociales, que incluye como objeto central la diversión a partir del deporte autóctono nacional, el Tejo. Será el primer campo de tejo que busca generar riqueza a partir de factores diferenciadores desarrollados bajo los conceptos teóricos de mercadeo, ventas, gerencia, estrategia y servicio al cliente; además de ser una buena oportunidad para promover y vender nuestra cultura nacional e internacionalmente. Play Tejo cambiará la forma de ver el tejo por el hecho de ser dirigido a un público diferente al tradicional con un enfoque más turístico y de recreación

Los recursos naturales y el patrimonio de la Nación

No presenta resumen

Los recursos naturales y el patrimonio de la Nación

No presenta resumen

Los recursos naturales y el patrimonio de la Nación

No presenta resumen

De “La Inmortalidad” de Kundera a la vasta ironía del decir: Exploración entre orfandades y miradas

These lines explore part of the polysemy present in Milan Kundera's novel  Immortality (Nesmrtelnost), with an emphasis on one of its main protagonists, Agnes, to account, among other things, for the use of irony as a power to say, especially in the contemporary world, under an inclination of its worth on the path of the ethical-moral imagination as an inevitable display of us.En estas líneas se explora parte de la polisemia presente en la novela La Inmortalidad (Nesmrtelnost) de Milan Kundera, con énfasis en una de sus principales protagonistas, Agnes, para dar cuenta, entre otras cosas, del uso de la ironía como potencia del decir, especialmente en el mundo contemporáneo, bajo una inclinación de su valía en el sendero de la imaginación ético-moral como despliegue inevitable del nosotras/nosotros. &nbsp

Violencia epistémica de género. Cuando el género es algo más que palabras

This brief essay explores from a transdisciplinary point of view, the epistemic violence as epistemic violence of gender, considering some places of enunciation and performance of women, valuing them as makers of culture, knowledge and society. The author is inspired by everyday life and the hope of a world of justice and equality.Este breve ensayo explora transdisciplinariamente la violencia epistémica como violencia epistémica de género, considerando algunos lugares de enunciación y realización de las mujeres, valorándolas como hacedoras de cultura, de conocimiento y de sociedad. El autor se inspira en la cotidianidad y en la esperanza de un mundo de justicia e igualdad

Modulatory Role of Sensory Innervation on Hair Follicle Stem Cell Progeny during Wound Healing of the Rat Skin

BACKGROUND: The bulge region of the hair follicle contains resident epithelial stem cells (SCs) that are activated and mobilized during hair growth and after epidermal wounding. However, little is known about the signals that modulate these processes. Clinical and experimental observations show that a reduced supply of sensory innervation is associated with delayed wound healing. Since axon terminals of sensory neurons are among the components of the bulge SC niche, we investigated whether these neurons are involved in the activation and mobilization of the hair stem cells during wound healing. METHODOLOGY/PRINCIPAL FINDINGS: We used neonatal capsaicin treatment to reduce sensory terminals in the rat skin and performed morphometric analyses using design-based stereological methods. Epithelial proliferation was analyzed by quantifying the number of bromodeoxyuridine-labeled (BrdU(+)) nuclei in the epidermis and hair follicles. After wounding, the epidermis of capsaicin-treated rats presented fewer BrdU(+) nuclei than in control rats. To assess SC progeny migration, we employed a double labeling protocol with iododeoxyuridine and chlorodeoxyuridine (IdU(+)/CldU(+)). The proportion of double-labeled cells was similar in the hair follicles of both groups at 32 h postwounding. IdU(+)/CldU(+) cell proportion increased in the epidermis of control rats and decreased in treated rats at 61 h postwounding. The epidermal volume immunostained for keratin 6 was greater in treated rats at 61 h. Confocal microscopy analysis revealed that substance P (SP) and calcitonin gene-related peptide (CGRP) receptor immunoreactivity were both present in CD34(+) and BrdU-retaining cells of the hair follicles. CONCLUSIONS/SIGNIFICANCE: Our results suggest that capsaicin denervation impairs SC progeny egress from the hair follicles, a circumstance associated with a greater epidermal activation. Altogether, these phenomena would explain the longer times for healing in denervated skin. Thus, sensory innervation may play a functional role in the modulation of hair SC physiology during wound healing