Presencia de Helmintos en el Patro Triguero (Anas platyrhynchos diazi) del altiplano zacatecano, México

Waterfowl, such as the Mexican duck (Anas platyrhynchos diazi), are carriers of parasites that can affect the populations of different species distributed in the Zacatecano plateau, México. The objectives of the present study were to identify the species of helminths of the Mexican duck population of the Zacatecano plateau, and to compare the composition of helminths according to the sex of the ducks. Twenty four Mexican ducks (14 males and 10 females) were randomly collected in the following bodies of water: La Zacatecana dam, El Maguey pond, Matanuzka pond and the UMA pond system Los Jales of the Zacatecano Plateau. Necropsy was made in each collected duck to obtain and identify their parasites and to determine the level of parasitosis. Eight parasites belonging to four classes were identified: Trematode (3), Nematode (2), Acanthocephala (2) and Cestode (1), and corresponding to eight families: Polymorphidae (1), Hymenolepididae (1), Psilostomidae (1), Paranfistomidae (1), Echinostomatidae (1), Trychostrongylidae (1), Trichuridae (1) and Echinorhynquidae (1). The parasite with highest prevalence was Zygocotyle lunata (66.67%), and the species with lowest prevalence were Echiostomum revolutum, Capillaria sp. and Polymorphus ondatrae (4.17 % for each one). The prevalence of helminths between the sexes of Anatidae was similar (p>0.05). However, the parasitic intensity per class of helminth between sexes indicated a significant difference (p£0.05) for trematodes, acanthocephala and cestodes. The results of the present study agree with those reported by various authors for different species of ducks.Las aves acuáticas, como el pato triguero (Anas platyrhynchos diazi), son portadoras de parásitos que pueden afectar a las poblaciones de diferentes especies distribuidas en el altiplano zacatecano, México. El presente estudio tuvo como objetivos identificar las especies de helmintos de la población de pato triguero del altiplano zacatecano, y comparar la composición de helmintos de acuerdo al sexo de los patos. Se recolectaron aleatoriamente 24 patos triguero (14 machos y 10 hembras) de en los cuerpos de agua: presa La Zacatecana, bordo El Maguey, bordo Matanuzka y sistema de bordos de la UMA Los Jales del altiplano zacatecano. En cada pato recolectado se realizó la necropsia para obtener e identificar sus parásitos y determinar el nivel de parasitosis. Ocho parásitos pertenecientes a cuatro clases fueron identificados: Trematoda (3), Nematoda (2), Acantocephala (2) y Cestoda (1), y correspondientes a ocho familias: Polymorphidae (1), Hymenolepididae (1), Psilostomidae (1), Paranfistomidae (1), Echinostomatidae (1), Trychostrongylidae (1), Trichuridae (1) y Echinorhynquidae (1). El parásito con mayor prevalencia fue Zygocotyle lunata (66.67 %), y las especies con menor prevalencia fueron Echinostomum revolutum, Capillaria sp. y Polymorphus ondatrae (4.17 % para cada una). La prevalencia de helmintos entre los sexos de anátidos fue similar (p>0.05); sin embargo, la intensidad parasitaria por clase de helminto entre sexos indicó una diferencia significativa (p£0.05) para trematodos, acantocéfalos y cestodos. Los resultados del presente trabajo concuerdan con los reportados por varios autores para diferentes especies de patos

19n01, a broadly neutralizing antibody against omicron BA.1, BA.2, BA.4/5, and other SARS-CoV-2 variants of concern

Summary: This study reports the isolation and characterization of a human monoclonal antibody (mAb) called 19n01. This mAb was isolated by using single-cell RNAseq of B cells from donors infected with the ancestral strain. This mAb possesses a potent and broad capacity to bind and neutralize all previously circulating variants of concern (VOCs), including Omicron sublineages BA.1, BA.2, and BA.4/5. The pseudovirus neutralization assay revealed robust neutralization capacity against the G614 strain, BA.1, BA.2, and BA.4/5, with inhibitory concentration (IC50) values ranging from 0.0035 to 0.0164 μg/mL. The microneutralization assay using the G614 strain and VOCs demonstrated IC50 values of 0.013–0.267 μg/mL. Biophysical and structural analysis showed that 19n01 cross-competes with ACE2 binding to the receptor-binding domain (RBD) and the kinetic parameters confirmed the high affinity against the Omicron sublineages (KD of 61 and 30 nM for BA.2 and BA.4/5, respectively). These results suggest that the 19n01 is a remarkably potent and broadly reactive mAb

Correction to: Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

International audienceIn this article, the name of the GLORIA-AF investigator Anastasios Kollias was given incorrectly as Athanasios Kollias in the Acknowledgements. The original article has been corrected

Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry

Background: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. Methods: From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. Findings: 34,421 patients were included (70.0 ± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients (Odds Ratio [OR] and 95% Confidence Intervals (CI): 0.23 [0.22-0.25] and 0.66 [0.61-0.71], respectively), but higher in the Japanese subgroup. Asian ethnicity was also associated with higher risk of OAC discontinuation (Hazard Ratio [HR] and [95% CI]: 1.79 [1.67-1.92]), and lower risk of the primary composite outcome (HR [95% CI]: 0.86 [0.76-0.96]). Among the exploratory secondary outcomes, Asian ethnicity was associated with higher risks of thromboembolism and intracranial haemorrhage, and lower risk of major bleeding. Interpretation: Our results showed that Asian patients with AF showed suboptimal thromboembolic risk management and a specific risk profile of adverse outcomes; these differences may also reflect differences in country-specific factors. Ensuring integrated and appropriate treatment of these patients is crucial to improve their prognosis. Funding: The GLORIA-AF Registry was funded by Boehringer Ingelheim GmbH