Abordaje cualitativo del autocuidado en salud y seguridad laboral en una universidad colombiana, 2015-2016

Objetivo. Comprender las concepciones culturales y la construcción social sobre el autocuidado en salud y seguridad laboral en una muestra de trabajadores de una institución de educación superior en Bogotá, Colombia, sustentado en el modelo de consenso cultural de Romney. Material y métodos. Se llevó a cabo un estudio cualitativo de una muestra propositiva de 60 trabajadores a los que se les aplicaron listados libres, sorteo por montones y entrevistas semiestructuradas para obtener información que fue analizada mediante la factorización de componentes por conglomerados jerárquicos y escalas multidimensionales. Resultados. La concepción cultural sobre autocuidado en el grupo de trabajadores que participó, tuvo una alta consistencia cultural, que categoriza los términos en cinco componentes: valores (respeto, amor, honestidad); cualidades personales (autoestima, responsabilidad, prudencia, disciplina); prácticas (alimentación saludable, hacer ejercicio, aseo personal, evitar consumo de alcohol o tabaco, realizar pausas activas, usar elementos de protección personal, identificar y valorar los riesgos, recrearse, atender las recomendaciones médicas); consecuencias o efectos (bienestar, salud, seguridad, protección, felicidad) y entorno (contar con ambientes de trabajo que sean seguros, cómodos y agradables para vivir).Conclusiones. La prevención en ambientes de trabajo implica construir información acorde con la concepción cultural que tengan los grupos que conforman una organización

Qualitative approach to self-care in occupational health and safety at a Colombian university, 2015-2016

Objetivo. Comprender las concepciones culturales y la construcción social sobre el autocuidado en salud y seguridad laboral en una muestra de trabajadores de una institución de educación superior en Bogotá,&nbsObjective: Understanding the cultural conceptions and social construction of self-care regarding health and occupational safety rooted in Romney ́s cultural consensus model in a sample of workers belonging to the higher education sector within an institu

Abordaje cualitativo del autocuidado en salud y seguridad laboral en una universidad colombiana, 2015-2016

Objetivo. Comprender las concepciones culturales y la construcción social sobre el autocuidado en salud y seguridad laboral en una muestra de trabajadores de una institución de educación superior en Bogotá, Colombia, sustentado en el modelo de consenso cultural de Romney. Material y métodos. Se llevó a cabo un estudio cualitativo de una muestra propositiva de 60 trabajadores a los que se les aplicaron listados libres, sorteo por montones y entrevistas semiestructuradas para obtener información que fue analizada mediante la factorización de componentes por conglomerados jerárquicos y escalas multidimensionales. Resultados. La concepción cultural sobre autocuidado en el grupo de trabajadores que participó, tuvo una alta consistencia cultural, que categoriza los términos en cinco componentes: valores (respeto, amor, honestidad); cualidades personales (autoestima, responsabilidad, prudencia, disciplina); prácticas (alimentación saludable, hacer ejercicio, aseo personal, evitar consumo de alcohol o tabaco, realizar pausas activas, usar elementos de protección personal, identificar y valorar los riesgos, recrearse, atender las recomendaciones médicas); consecuencias o efectos (bienestar, salud, seguridad, protección, felicidad) y entorno (contar con ambientes de trabajo que sean seguros, cómodos y agradables para vivir).Conclusiones. La prevención en ambientes de trabajo implica construir información acorde con la concepción cultural que tengan los grupos que conforman una organización

Serotype distribution of pneumococci isolated from pediatric patients with acute otitis media and invasive infections, and potential coverage of pneumococcal conjugated vaccines

Fil: Reijtman, Vanesa R. Servicio de Microbiología, Hospital de Pediatría, Ciudad Autónoma de Buenos Aires; Argentina.Fil: Fossati, Sofía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Hernández, Claudia. Servicio de Microbiología, Hospital de Pediatría, Ciudad Autónoma de Buenos Aires; Argentina.Fil: Sommerfleck, Patricia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Bernáldez, Patricia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Litterio, Mirta. Servicio de Microbiología, Hospital de Pediatría, Ciudad Autónoma de Buenos Aires; Argentina.Fil: Berberian, Griselda. Servicio de Control Epidemiológico e Infectología, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”; Argentina.Fil: Regueira, Mabel. Servicio de Otorrinolaringología, Hospital de Pediatría, Ciudad Autónoma de Buenos Aires; Argentina.Fil: Lopardo, Horacio. Servicio de Microbiología, Hospital de Pediatría, Ciudad Autónoma de Buenos Aires; Argentina.A 16-month prospective, descriptive study was conducted on pneumococcal serotype distribution isolated from children with acute otitis media (AOM) and invasive infections (INV). Eighty-nine children with pneumococcal INV and 324 with a first episode of AOM were included. Bacterial pathogens (N = 326) were isolated from the middle-ear fluid of 250 patients. A total of 30 pneumococcal serotypes were identified. Prevalent serotypes were 14, 19A, 9V, 3, 19F, 6A, 23F, and 18C in AOM and 14, 1, 19A, 5, 12F, 6B, and 18C in INV. Potential coverage with PCV10 vaccine would be 46.5 % and 60.7 % for pneumococci involved in AOM and INV, respectively; it would be 71.7 % and 73 % with PCV13. PCV10, conjugated with a Haemophilus protein, would have an immunologic coverage of 39.9 % for AOM vs. 18.5 % with PCV13. However, differences in the prevention of INV were crucial for the decision to include the 13-valent vaccine in the national calendar for children less than two years old in Argentina

Serotype distribution of pneumococci isolated from pediatric patients with acute otitis media and invasive infections, and potential coverage of pneumococcal conjugated vaccines

Fil: Reijtman, Vanesa R. Servicio de Microbiología, Hospital de Pediatría, Ciudad Autónoma de Buenos Aires; Argentina.Fil: Fossati, Sofía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Hernández, Claudia. Servicio de Microbiología, Hospital de Pediatría, Ciudad Autónoma de Buenos Aires; Argentina.Fil: Sommerfleck, Patricia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Bernáldez, Patricia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Litterio, Mirta. Servicio de Microbiología, Hospital de Pediatría, Ciudad Autónoma de Buenos Aires; Argentina.Fil: Berberian, Griselda. Servicio de Control Epidemiológico e Infectología, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”; Argentina.Fil: Regueira, Mabel. Servicio de Otorrinolaringología, Hospital de Pediatría, Ciudad Autónoma de Buenos Aires; Argentina.Fil: Lopardo, Horacio. Servicio de Microbiología, Hospital de Pediatría, Ciudad Autónoma de Buenos Aires; Argentina.A 16-month prospective, descriptive study was conducted on pneumococcal serotype distribution isolated from children with acute otitis media (AOM) and invasive infections (INV). Eighty-nine children with pneumococcal INV and 324 with a first episode of AOM were included. Bacterial pathogens (N = 326) were isolated from the middle-ear fluid of 250 patients. A total of 30 pneumococcal serotypes were identified. Prevalent serotypes were 14, 19A, 9V, 3, 19F, 6A, 23F, and 18C in AOM and 14, 1, 19A, 5, 12F, 6B, and 18C in INV. Potential coverage with PCV10 vaccine would be 46.5 % and 60.7 % for pneumococci involved in AOM and INV, respectively; it would be 71.7 % and 73 % with PCV13. PCV10, conjugated with a Haemophilus protein, would have an immunologic coverage of 39.9 % for AOM vs. 18.5 % with PCV13. However, differences in the prevention of INV were crucial for the decision to include the 13-valent vaccine in the national calendar for children less than two years old in Argentina

Summer bloom of Vulcanodinium rugosum in Cienfuegos Bay (Cuba) associated to dermatitis in swimmers

The marine dinoflagellate Vulcanodinium rugosum produces powerful paralyzing and cytotoxic compounds named pinnatoxins (PnTX) and portimines. Even though, no related human intoxication episodes following direct exposure in seawater or the ingestion of contaminated seafood have been documented so far. This study aimed at investigating a dinoflagellate bloom linked to acute dermatitis cases in two recreational beaches in Cienfuegos Bay, Cuba. We used epidemiological and clinical data from 60 dermatitis cases consisting of individuals in close contact with the bloom. Seawater physical-chemical properties were described, and the microorganism causing the bloom was identified by means of light and scanning electron microscopy. Morphological identification was confirmed genetically by sequencing the internal transcribed spacers ITS1 and ITS2, and the 5.8S rDNA region. Toxic compounds were identified from a bloom extract using liquid chromatography (LC) coupled to high-resolution mass spectrometry (HRMS), and their concentrations were estimated based on low-resolution tandem mass spectrometry (LC-MS/MS). Sixty people who had prolonged contact with the dinoflagellate bloom suffered acute dermal irritation. Most patients (79.2%) were children and had to be treated with antibiotics; some required >5-day hospitalization. Combined morphological and genetic characters indicated V. rugosum as the causative agent of the bloom. rDNA sequences of the V. rugosum genotype found in the bloom aligned with others from Asia, including material found in the ballast tank of a ship in Florida. The predominant toxins in the bloom were portimine, PnTX-F and PnTX-E, similar to strains originating from the Pacific Ocean. This bloom was associated with unusual weather conditions such as frequent and prolonged droughts. Our findings indicate a close link between the V. rugosum bloom and a dermatitis outbreak among swimmers in Cienfuegos Bay. Phylogenetic evidence suggests a recent introduction of V. rugosum from the Pacific Ocean into Caribbean waters, possibly via ballast water

Superior Efficacy and Safety of a Nonemulsive Variant of the NGcGM3/VSSP Vaccine in Advanced Breast Cancer Patients

NGcGM3 ganglioside is a tumor-specific antigen expressed in human breast tumors. The NGcGM3/VSSP vaccine, consisting in very small-sized proteoliposomes (VSSP) obtained by the incorporation of NGcGM3 into the outer membrane protein complex of Neisseria meningitidis , has been previously tested in a Phase II trial in patients with metastatic breast cancer (MBC) but emulsified with Montanide ISA 51. An Expanded Access study was carried out in MBC patients aiming to find if a nonemulsive formulation of NGcGM3/VSSP, without Montanide ISA 51, could be more safe and effective. A total of 104 patients were vaccinated with the nonemulsive formulation (900 μg), subcutaneously (SC), or with the emulsive formulation (200 μg), intramuscularly (IM). An intent-to-treat analysis of efficacy was performed with all patients, and 93 patients were split off according to the site of metastases (visceral/nonvisceral). Of note, SC-treated patients exhibited a superior median overall survival (OS) than IM-treated patients (23.6 vs. 8.2 months; log rank P = 0.001). Even though in the subset of patients with nonvisceral metastases SC vaccination duplicated the median OS compared to the alternative option (31.6 vs. 16.5 months), this difference did not reach statistical significance (log rank P = 0.118). Curiously, in patients with visceral metastases, the advantage of the nonemulsive formulation was more apparent (median OS 21.0 vs. 6.2 months; log rank P = 0.005). The vaccine was safe for both formulations

KOSMOS 2017 Peru mesocosm study: overview data

Eastern boundary upwelling systems (EBUS) are among the most productive marine ecosystems on Earth. The production of organic material is fueled by upwelling of nutrient-rich deep waters and high incident light at the sea surface. However, biotic and abiotic factors can mod- ify surface production and related biogeochemical processes. Determining these factors is important because EBUS are considered hotspots of climate change, and reliable predic- tions of their future functioning requires understanding of the mechanisms driving the biogeochemical cycles therein. In this field experiment, we used in situ mesocosms as tools to improve our mechanistic understanding of processes con- trolling organic matter cycling in the coastal Peruvian up- welling system. Eight mesocosms, each with a volume of ∼ 55 m3, were deployed for 50 d ∼ 6 km off Callao (12◦ S) during austral summer 2017, coinciding with a coastal El Niño phase. After mesocosm deployment, we collected sub- surface waters at two different locations in the regional oxy- gen minimum zone (OMZ) and injected these into four meso- cosms (mixing ratio ≈ 1.5 : 1 mesocosm: OMZ water). The focus of this paper is on temporal developments of organic matter production, export, and stoichiometry in the indi- vidual mesocosms. The mesocosm phytoplankton commu- nities were initially dominated by diatoms but shifted to- wards a pronounced dominance of the mixotrophic dinoflag- ellate (Akashiwo sanguinea) when inorganic nitrogen was exhausted in surface layers. The community shift coincided with a short-term increase in production during the A. san- guinea bloom, which left a pronounced imprint on organic matter C : N : P stoichiometry. However, C, N, and P export fluxes did not increase because A. sanguinea persisted in the water column and did not sink out during the experiment. Accordingly, export fluxes during the study were decou- pled from surface production and sustained by the remain- ing plankton community. Overall, biogeochemical pools and fluxes were surprisingly constant for most of the experiment. We explain this constancy by light limitation through self- shading by phytoplankton and by inorganic nitrogen limita- tion which constrained phytoplankton growth. Thus, gain and loss processes remained balanced and there were few oppor- tunities for blooms, which represents an event where the sys- tem becomes unbalanced. Overall, our mesocosm study re- vealed some key links between ecological and biogeochem- ical processes for one of the most economically important regions in the oceans