Realcompactness in maximal and submaximal spaces

AbstractWe study realcompactness in the classes of submaximal and maximal spaces. It is shown that a normal submaximal space of cardinality less than the first measurable is realcompact. ZFC examples of submaximal not realcompact and maximal not realcompact spaces are constructed. These examples answer questions posed in [O.T. Alas, M. Sanchis, M.G. Tkačenko, V.V. Tkachuk, R.G. Wilson, Irresolvable and submaximal spaces: homogeneity versus σ-discreteness and new ZFC examples, Topology Appl. 107 (3) (2000) 259–273] and generalize some results from [D.P. Baturov, On perfectly normal dense subspaces of products, Topology Appl. 154 (2) (2007) 374–383]

Graphical tools for helping firefighters in victim rescues. Assessment during a live fire training program

This study compares three different methods to communicate the features of a building to firefighters, before starting a victim rescue during a live fire training program. Participants in this study did not previously know the hotel used for developing the activities. The effective number of participants was 144, all professional firefighters. One of the exercises in this training program was thoroughly designed not only for training purposes, but also to test different guide versions. The innovative guides were based on two different technologies (simple stapled sheets of paper and digital content displayed on a tablet) and were developed using several graphical tools (conventional pictures, aerial images captured with drone, 3D models, 360° pictures, etc.). With the intention of facilitating firefighters’ activity during a victim rescue, results obtained using these tools were compared with a conventional communication method. The assessment methodology applied in this study included the use of an anonym questionnaire, as well as the analysis of the videos captured with action cameras, attached with a harness to the chest of two of the four firefighters in every team, during the training activities. Thanks to these videos, it was possible to compare the time required for rescuing the victim and to observe followed paths, visited rooms and substantial information about the tested tools, including valuable participants’ comments. For in emergency situations, the tools described in this paper were preferred to the already existent self-protection plans, usually considered too extensive for fast communication, a matter of special importance in victim rescues

Designing and implementing a massive open online course: Lessons learnt

•In this paper, we describe the design, implementation, and evaluation of a Massive Open Online Course, or MOOC, on good practice in the application of Intellectual Property. It is aimed primarily at teachers and students, and taught in Spanish. We have used the Spanish legislation on Intellectual Property. This paper outlines the structure and content of a course developed on an ad-hoc basis, and describes its evaluation by participants in questionnaires and a final survey. The results of the initial questionnaire are framed by a) the participant''s profile, and b) by consideration of the MOOC''s implementation, given the results of the satisfaction survey. In this paper we describe the advantages of the MOOC and identify areas for improvement

Acellular dermal matrix in soft tissue reconstruction prior to bone grafting. A case report

When hard tissue augmentation is scheduled as a part of an oral rehabilitation, prior to the treatment, it is important to assess if the quality of the underlying gingiva at the recipient site can support the bone grafting procedure. The most frequent complication during autologous onlay grafts are wound dehiscences in the recipient site, so the integrity of soft tissues is a basic aspect of successful reconstructive and plastic surgical procedure. Connective tissue grafts can improve the quality and quantity of soft tissue in oral sites where a hard tissue reconstruction is going to take place. However, particularly when large grafts are harvested, the autogenous donor site can present significant postoperative morbidity, such as necrosis of the palate fibromucosa and bone exposition, pain and bleeding. Another important limitation with the use of autogenous grafts is the limited supply of donor connective tissue. If a large site needs to be grafted, more than one surgical procedure may be required. An Acellular Dermal Matrix (ADM) graft has become increasingly popular as a substitute for donor connective tissue, eliminating the disadvantages described for the autogenous donor graft. The amount of tissue harvested is unlimited, so it gives an option for treating patients that have inadequate harvestable tissue or that present a large defect to be treated. The outcome of using ADM as a matrix for soft tissue reconstruction 12 weeks before bone grafting can reduce the risk of exposure and failure of the bone graft

La divulgación científica de la Universidad de Zaragoza a través del Servicio de Información y Noticias Científicas durante los años 2009 y 2010

El trabajo aborda la difusión científica que la Universidad de Zaragoza (UZ) ha llevado a cabo por medio del Servicio de Información y Noticias Científicas (SINC) durante los años 2009 y 2010. A partir de la recuperación, descripción y análisis de todos los documentos, relacionados con la UZ que han sido publicados en esta agencia de noticias se ha realizado un ranking de universidades y se han identificado los autores, fuentes, materias, entidades, personas y géneros periodísticos más destacados. También se han comparado los resultados obtenidos con los del trabajo realizado por Araceli Cebamanos Catalán, relativo a los años 2011-2012. Como conclusión se propone continuar con el estudio para seguir identificando la presencia de la UZ en este medio de comunicación e impulsar la difusión de SINC entre los investigadores de UZ como medio de divulgación de los resultados obtenidos en las investigaciones científicas

KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling

Local regulation of protein synthesis allows a neuron to rapidly alter the proteome in response to synaptic signals, an essential mechanism in synaptic plasticity that is altered in many neurological diseases. Synthesis of many synaptic proteins is under local control and much of this regulation occurs through structures termed RNA granules. KIS is a protein kinase that associates with stathmin, a modulator of the tubulin cytoskeleton. Furthermore, KIS is found in RNA granules and stimulates translation driven by the β-actin 3'UTR in neurites. Here we explore the physiological and molecular mechanisms underlying the action of KIS on hippocampal synaptic plasticity in mice. KIS downregulation compromises spine development, alters actin dynamics, and reduces postsynaptic responsiveness. The absence of KIS results in a significant decrease of protein levels of PSD-95, a postsynaptic scaffolding protein, and the AMPAR subunits GluR1 and GluR2 in a CPEB3-dependent manner. Underlying its role in spine maturation, KIS is able to suppress the spine developmental defects caused by CPEB3 overexpression. Moreover, either by direct or indirect mechanisms, KIS counteracts the inhibitory activity of CPEB3 on the GluR2 3'UTR at both mRNA translation and polyadenylation levels. Our study provides insights into the mechanisms that mediate dendritic spine morphogenesis and functional synaptic maturation, and suggests KIS as a link regulating spine cytoskeleton and postsynaptic activity in memory formation

Effect of ultra-high-pressure homogenization processing on the microbiological, physicochemical, and sensory characteristics of fish broth

The effect of ultra-high-pressure homogenization (UHPH) treatments at 300 MPa at inlet temperatures (Ti) between 45 and 75 °C on the microbiological, physical, and sensorial characteristics of fish broth was evaluated. Before the application of UHPH treatments, different fish broth formulations were tested, selecting the formula with the best organoleptic and nutritional characteristics and the lowest cost, containing 45% monkfish heads and rock fish in the same proportion. The microbiological shelf-life of fish broth during cold storage at 4 and 8 °C was extended by a minimum of 20 days by applying UHPH treatments at inlet temperatures (Ti) between 45 and 65 °C. Fish broth UHPH-treated at Ti = 75 °C was microbiologically sterile during storage at 4 °C, 8 °C, and room temperature. Fish broth UHPH-treated was physically stable, significantly reducing the particle size. Color showed higher luminosity and lower yellowness as the inlet temperature increased. In fish broth UHPH-treated at Ti = 75 °C, selected for its microbiological stability, no differences were observed in the nutritional composition, antioxidant activity, and sensorial perception compared to untreated fish broth. Hence, UHPH treatments showed to be an alternative to preserving fish broth with an improved microbiological shelf-life and good sensorial characteristics.Postprint (published version

Combined effects of ultra-high pressure homogenization and short-wave ultraviolet radiation on the properties of cloudy apple juice

This work addresses the physicochemical, enzymatic and sensory changes in cloudy apple juice treated by ultra- high pressure homogenization (UHPH) and short-wave ultraviolet radiation (UV–C) applied at 20 ¿C. Those technologies were applied in single and combined treatments at different UHPH pressures (200–300 MPa) and UV-C doses (14.3–27.8 J/mL). UV-C treatments could not effectively inactivate enzymes, but treatments at 300- MPa UHPH reduced pectin methylesterase activity to a 24.6%, and polyphenol oxidase activity was not detected. Those samples presented a higher antioxidant capacity (283% measured by FRAP, and 286.4% by DPPH) than in non-treated juice, and after a combination with 28.7 J/mL of UV-C the polyphenols content augmented to 277.6%. Sensory evaluation revealed that UHPH at 300 MPa and UV-C at 21.5 J/mL significantly changed perceptible odour and overall flavour of cloudy apple juice, while treatments at 200 MPa didn’t produce any significant changes in the different parameters.Postprint (published version

Short Wave Ultraviolet Light (UV-C) Effectiveness in the Inactivation of Bacterial Spores Inoculated in Turbid Suspensions and in Cloudy Apple Juice

Liquid foods might present interferences in their optical properties that can reduce the effectiveness of short-wave ultraviolet radiation (UV-C) treatments used for sterilization purposes. The effect of turbidity as UV-C interference factor against the inactivation of bacterial spores was analysed by using phosphate-buffered saline solutions (PBS) of different turbidity values (2000, 2500, and 3000 NTU) which were adjusted with the addition of apple fibre. These suspensions were inoculated with spores of Bacillus subtilis and Alicyclobacillus acidoterrestris. While higher UV-C doses increased the inactivation rates of spores, these were reduced when turbidity values increased; a dose of 28.7 J/mL allowed inactivation rates of B. subtilis spores of 3.96 Log in a 2000-NTU suspension compared with 2.81 Log achieved in the 3000-NTU one. Spores of B. subtilis were more UV-C-resistant than A. acidoterrestris. Cloudy apple juice inoculated with A. acidoterrestris spores was processed by UV-C at different doses in a single pass and with recirculation of the matrix through the reactor. Inactivation increased significantly with recirculation, surpassing 5 Log after 125 J/mL compared with 0.13 Log inactivation after a single-pass treatment at the same UV-C dose. UV-C treatments with recirculation affected the optical properties (absorption coefficient at 254 nm and turbidity) of juice and increased browning as UV-C doses became higher

Desarrollo de proyectos por roles. Análisis de la influencia del rol desempeñado en el proceso de enseñanza-aprendizaje

En este trabajo comprobamos que la implantación de roles en el aprendizaje colaborativo, no afecta negativamente a los resultados obtenidos por los alumnos que realizan sus trabajos en la asignatura de Oficina Técnica del Grado en Ingeniería de Diseño Industrial y desarrollo de Producto de la Universidad de Zaragoza. Para lograr este objetivo, se analizan los resultados obtenidos por los alumnos en tres líneas. Primero se comparan las calificaciones obtenidas por los alumnos en los cursos previos a la definición de los roles con los resultados de los cursos en los que se han implantado los roles, para ver si se detectan grandes cambios que puedan relacionar la forma de trabajo con la tasa de éxito. En segundo lugar, se analiza si hay desajustes en las calificaciones de cada rol, por si alguno de los roles presenta más dificultad que otro. Por último, se analizan las calificaciones obtenidas en el examen de la asignatura, según el rol desempeñado en cada uno de los trabajos, para ver si la definición de los roles afecta a la tasa de éxito de los alumnos